Svoboda | Graniru | BBC Russia | Golosameriki | Facebook
 
 
Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (24,512)

Search Parameters:
Keywords = artificial intelligence

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
17 pages, 6523 KiB  
Article
Lightweight Model Development for Forest Region Unstructured Road Recognition Based on Tightly Coupled Multisource Information
by Guannan Lei, Peng Guan, Yili Zheng, Jinjie Zhou and Xingquan Shen
Forests 2024, 15(9), 1559; https://doi.org/10.3390/f15091559 (registering DOI) - 4 Sep 2024
Abstract
Promoting the deployment and application of embedded systems in complex forest scenarios is an inevitable developmental trend in advanced intelligent forestry equipment. Unstructured roads, which lack effective artificial traffic signs and reference objects, pose significant challenges for driverless technology in forest scenarios, owing [...] Read more.
Promoting the deployment and application of embedded systems in complex forest scenarios is an inevitable developmental trend in advanced intelligent forestry equipment. Unstructured roads, which lack effective artificial traffic signs and reference objects, pose significant challenges for driverless technology in forest scenarios, owing to their high nonlinearity and uncertainty. In this research, an unstructured road parameterization construction method, “DeepLab-Road”, based on tight coupling of multisource information is proposed, which aims to provide a new segmented architecture scheme for the embedded deployment of a forestry engineering vehicle driving assistance system. DeepLab-Road utilizes MobileNetV2 as the backbone network that improves the completeness of feature extraction through the inverse residual strategy. Then, it integrates pluggable modules including DenseASPP and strip-pooling mechanisms. They can connect the dilated convolutions in a denser manner to improve feature resolution without significantly increasing the model size. The boundary pixel tensor expansion is then completed through a cascade of two-dimensional Lidar point cloud information. Combined with the coordinate transformation, a quasi-structured road parameterization model in the vehicle coordinate system is established. The strategy is trained on a self-built Unstructured Road Scene Dataset and transplanted into our intelligent experimental platform to verify its effectiveness. Experimental results show that the system can meet real-time data processing requirements (≥12 frames/s) under low-speed conditions (≤1.5 m/s). For the trackable road centerline, the average matching error between the image and the Lidar was 0.11 m. This study offers valuable technical support for the rejection of satellite signals and autonomous navigation in unstructured environments devoid of high-precision maps, such as forest product transportation, agricultural and forestry management, autonomous inspection and spraying, nursery stock harvesting, skidding, and transportation. Full article
(This article belongs to the Special Issue Modeling of Vehicle Mobility in Forests and Rugged Terrain)
Show Figures

Figure 1

20 pages, 19697 KiB  
Article
Efficacy Evaluation of You Only Learn One Representation (YOLOR) Algorithm in Detecting, Tracking, and Counting Vehicular Traffic in Real-World Scenarios, the Case of Morelia México: An Artificial Intelligence Approach
by José A. Guzmán-Torres, Francisco J. Domínguez-Mota, Gerardo Tinoco-Guerrero, Maybelin C. García-Chiquito and José G. Tinoco-Ruíz
AI 2024, 5(3), 1594-1613; https://doi.org/10.3390/ai5030077 (registering DOI) - 4 Sep 2024
Abstract
This research explores the efficacy of the YOLOR (You Only Learn One Representation) algorithm integrated with the Deep Sort algorithm for real-time vehicle detection, classification, and counting in Morelia, Mexico. The study aims to enhance traffic monitoring and management by leveraging advanced deep [...] Read more.
This research explores the efficacy of the YOLOR (You Only Learn One Representation) algorithm integrated with the Deep Sort algorithm for real-time vehicle detection, classification, and counting in Morelia, Mexico. The study aims to enhance traffic monitoring and management by leveraging advanced deep learning techniques. The methodology involves deploying the YOLOR model at six key monitoring stations, with varying confidence levels and pre-trained weights, to evaluate its performance across diverse traffic conditions. The results demonstrate that the model is effective compared to other approaches in classifying multiple vehicle types. The combination of YOLOR and Deep Sort proves effective in tracking vehicles and distinguishing between different types, providing valuable data for optimizing traffic flow and infrastructure planning. This innovative approach offers a scalable and precise solution for intelligent traffic management, setting new methodologies for urban traffic monitoring systems. Full article
(This article belongs to the Section AI Systems: Theory and Applications)
Show Figures

Figure 1

12 pages, 5880 KiB  
Article
Preparation of Aluminum-Based Superhydrophobic Surfaces for Fog Collection by Bioinspired Sarracenia Microstructures
by Yunjie Guo, Jie Li, Lisheng Ma, Wentian Shi, Yuke Wang, Shuo Fu and Yanning Lu
Biomimetics 2024, 9(9), 535; https://doi.org/10.3390/biomimetics9090535 (registering DOI) - 4 Sep 2024
Abstract
Freshwater shortage is a growing problem. Inspired by the Sarracenia trichome fog-trapping and ultrafast water-transport structure, a series of hierarchical textured surfaces with high-low ribs with different wettabilities was prepared based on laser processing combined with dip modification. Through fog-collection performance tests, it [...] Read more.
Freshwater shortage is a growing problem. Inspired by the Sarracenia trichome fog-trapping and ultrafast water-transport structure, a series of hierarchical textured surfaces with high-low ribs with different wettabilities was prepared based on laser processing combined with dip modification. Through fog-collection performance tests, it was found that the samples with superhydrophobicity and low adhesion had the best fog-collection effect. In addition, it was observed that the fog-collection process of different microstructured samples was significantly different, and it was analysed that the fog-collection process was composed of two aspects: directional condensation and directional transport of droplets, which were affected by the low ribs number and rib height ratio. A design parameter was given to create the Sarracenia trichome-like structure to achieve a fast water transport mode. This study provides a good reference for the development and preparation of fog-collection surfaces. Full article
Show Figures

Figure 1

16 pages, 628 KiB  
Article
Cooperative Jamming-Based Physical-Layer Group Secret and Private Key Generation
by Shiming Fu, Tong Ling, Jun Yang and Yong Li
Entropy 2024, 26(9), 758; https://doi.org/10.3390/e26090758 (registering DOI) - 4 Sep 2024
Abstract
This paper explores physical layer group key generation in wireless relay networks with a star topology. In this setup, the relay node plays the role of either a trusted or untrusted central node, while one legitimate node (Alice) acts as the reference node. [...] Read more.
This paper explores physical layer group key generation in wireless relay networks with a star topology. In this setup, the relay node plays the role of either a trusted or untrusted central node, while one legitimate node (Alice) acts as the reference node. The channel between the relay and Alice serves as the reference channel. To enhance security during the channel measurement stage, a cooperative jamming-based scheme is proposed in this paper. This scheme allows the relay to obtain superimposed channel observations from both the reference channel and other relay channels. Then, a public discussion is utilized to enable all nodes to obtain estimates of the reference channel. Subsequently, the legitimate nodes can agree on a secret key (SK) that remains secret from the eavesdropper (Eve), or a private key (PK) that needs to be secret from both the relay and Eve. This paper also derives the lower and upper bounds of the SK/PK capacity. Notably, it demonstrates that there exists only a small constant difference between the SK/PK upper and lower bounds in the high signal-to-noise ratio (SNR) regime. Simulation results confirm the effectiveness of the proposed scheme for ensuring security and efficiency of group key generation. Full article
(This article belongs to the Section Information Theory, Probability and Statistics)
Show Figures

Figure 1

16 pages, 6306 KiB  
Article
Enhancing Building Services in Higher Education Campuses through Participatory Science
by Mohammed Itair, Isam Shahrour, Rani El Meouche and Nizar Hattab
Buildings 2024, 14(9), 2784; https://doi.org/10.3390/buildings14092784 (registering DOI) - 4 Sep 2024
Abstract
This paper explores how participatory science can enhance building services on a higher education campus. The use of participatory science aims to involve students, faculty members, and technical teams in improving the management of the campus through their participation in data collection and [...] Read more.
This paper explores how participatory science can enhance building services on a higher education campus. The use of participatory science aims to involve students, faculty members, and technical teams in improving the management of the campus through their participation in data collection and evaluation of the building services. It represents a valuable alternative for campuses needing more building monitoring. The paper also shows how the performance of participatory science could be improved by combining digital technologies such as Building Information Modeling (BIM) and artificial intelligence (AI). The framework is applied to the Faculty of Engineering at An-Najah National University to improve the building services of the campus. A combination of users’ feedback and AI-generated synthetic data is used to explore the performance of the proposed method. Results confirm the high potential of participatory science for improving the services and quality of life on higher education campuses. This is achieved through students’ active participation and involvement in data collection and reporting on their individual experiences. Full article
(This article belongs to the Special Issue Smart Asset Management for Sustainable Built Environment)
Show Figures

Figure 1

28 pages, 2466 KiB  
Review
Navigating Governmental Choices: A Comprehensive Review of Artificial Intelligence’s Impact on Decision-Making
by Gustavo Caiza, Verónica Sanguña, Natalia Tusa, Violeta Masaquiza, Alexandra Ortiz and Marcelo V. Garcia
Informatics 2024, 11(3), 64; https://doi.org/10.3390/informatics11030064 - 4 Sep 2024
Abstract
The integration of artificial intelligence (AI) into government decision-making is rapidly gaining traction in public administration and politics. This scoping review, guided by PRISMA protocols, examines 50 articles from reputable sources like Scopus and SpringerLink to analyze the trends, benefits, and challenges of [...] Read more.
The integration of artificial intelligence (AI) into government decision-making is rapidly gaining traction in public administration and politics. This scoping review, guided by PRISMA protocols, examines 50 articles from reputable sources like Scopus and SpringerLink to analyze the trends, benefits, and challenges of AI in governance. While AI offers substantial potential to enhance government efficiency and service delivery, significant barriers remain, including concerns about bias, transparency, public acceptance, and accountability. This review underscores the need for ongoing research and dialogue on the ethical, social, and practical implications of AI in government to ensure the responsible and inclusive adoption of AI-driven public services. Full article
(This article belongs to the Section Social Informatics and Digital Humanities)
Show Figures

Figure 1

33 pages, 1702 KiB  
Article
Five-Element Cycle Optimization Algorithm Based on an Integrated Mutation Operator for the Traveling Thief Problem
by Yue Xiang, Jingjing Guo, Zhengyan Mao, Chao Jiang and Mandan Liu
Symmetry 2024, 16(9), 1153; https://doi.org/10.3390/sym16091153 - 4 Sep 2024
Abstract
This paper presents a novel algorithm named Five-element Cycle Integrated Mutation Optimization (FECOIMO) for solving the Traveling Thief Problem (TTP). The algorithm introduces a five-element cycle structure that integrates various mutation operations to enhance both global exploration and local exploitation capabilities. In experiments, [...] Read more.
This paper presents a novel algorithm named Five-element Cycle Integrated Mutation Optimization (FECOIMO) for solving the Traveling Thief Problem (TTP). The algorithm introduces a five-element cycle structure that integrates various mutation operations to enhance both global exploration and local exploitation capabilities. In experiments, FECOIMO was extensively tested on 39 TTP instances of varying scales and compared with five common metaheuristic algorithms: Enhanced Simulated Annealing (ESA), Improved Grey Wolf Optimization Algorithm (IGWO), Improved Whale Optimization Algorithm (IWOA), Genetic Algorithm (GA), and Profit-Guided Coordination Heuristic (PGCH). The experimental results demonstrate that FECOIMO outperforms the other algorithms across all instances, particularly excelling in large-scale instances. The results of the Friedman test show that FECOIMO significantly outperforms other algorithms in terms of average solution, maximum solution, and solution standard deviation. Additionally, although FECOIMO has a longer execution time, its complexity is comparable to that of other algorithms, and the additional computational overhead in solving complex optimization problems translates into better solutions. Therefore, FECOIMO has proven its effectiveness and robustness in handling complex combinatorial optimization problems. Full article
Show Figures

Figure 1

19 pages, 3351 KiB  
Article
Automatizing Automatic Controller Design Process: Designing Robust Automatic Controller under High-Amplitude Disturbances Using Particle Swarm Optimized Neural Network Controller
by Celal Onur Gökçe
Appl. Sci. 2024, 14(17), 7859; https://doi.org/10.3390/app14177859 - 4 Sep 2024
Abstract
In this study, a novel approach of designing automatic control systems with the help of AI tools is proposed. Given plant dynamics, expected references, and expected disturbances, the design of an optimal neural network-based controller is performed automatically. Several common reference types are [...] Read more.
In this study, a novel approach of designing automatic control systems with the help of AI tools is proposed. Given plant dynamics, expected references, and expected disturbances, the design of an optimal neural network-based controller is performed automatically. Several common reference types are studied including step, square, sine, sawtooth, and trapezoid functions. Expected reference–disturbance pairs are used to train the system for finding optimal neural network controller parameters. A separate test set is used to test the system for unexpected reference–disturbance pairs to show the generalization performance of the proposed system. Parameters of a real DC motor are used to test the proposed approach. The real DC motor’s parameters are estimated using a particle swarm optimization (PSO) algorithm. Initially, a proportional–integral (PI) controller is designed using a PSO algorithm to find the simple controller’s parameters optimally and automatically. Starting with the neural network equivalent of the optimal PI controller, the optimal neural network controller is designed using a PSO algorithm for training again. Simulations are conducted with estimated parameters for a diverse set of training and test patterns. The results are compared with the optimal PI controller’s performance and reported in the corresponding section. Encouraging results are obtained, suggesting further research in the proposed direction. For low-disturbance scenarios, even simple controllers can have acceptable performance, but the real quality of a proposed controller should be shown under high-amplitude and difficult disturbances, which is the case in this study. The proposed controller shows higher performance, especially under high disturbances, with an 8.6% reduction in error rate on average compared with the optimal PI controller, and under high-amplitude disturbances, the performance difference is of more than 2.5 folds. Full article
(This article belongs to the Special Issue Applications of Data Science and Artificial Intelligence)
Show Figures

Figure 1

6 pages, 172 KiB  
Editorial
Machine Learning Applications in Seismology
by Ke Jia and Shiyong Zhou
Appl. Sci. 2024, 14(17), 7857; https://doi.org/10.3390/app14177857 - 4 Sep 2024
Abstract
The comprehension of earthquakes and natural hazards, including volcanic eruptions and landslides, as well as explosions, through observational data is a pivotal activity within the field of seismology [...] Full article
(This article belongs to the Special Issue Machine Learning Applications in Seismology)
16 pages, 275 KiB  
Article
Fourier Series Related to p-Trigonometric Functions
by Ali Hamzah Alibrahim and Saptarshi Das
Axioms 2024, 13(9), 600; https://doi.org/10.3390/axioms13090600 - 4 Sep 2024
Abstract
In this paper, we introduce the concept of generalized Fourier series, generated by the p-trigonometric functions, namely cosp and sinp, recently introduced related to the generalized complex numbers systems. The aim of this study is to represent a periodic signal as a [...] Read more.
In this paper, we introduce the concept of generalized Fourier series, generated by the p-trigonometric functions, namely cosp and sinp, recently introduced related to the generalized complex numbers systems. The aim of this study is to represent a periodic signal as a sum of p-sine and p-cosine functions. In order to achieve this, we first present the integrals of the product of the same or different family of p-trigonometric functions over the full period of these functions to understand the orthogonality properties. Next, we use these integrals to derive the coefficients of the generalized p-Fourier series along with a few examples. The generalized Fourier series can be used to expand an arbitrary forcing function in the solution of a non-homogeneous linear ordinary differential equation (ODE) with constant coefficients. Full article
(This article belongs to the Special Issue Advanced Approximation Techniques and Their Applications II)
25 pages, 2212 KiB  
Review
A Review of Smart Photovoltaic Systems Which Are Using Remote-Control, AI, and Cybersecurity Approaches
by Andreea-Mihaela Călin (Comșiț), Daniel Tudor Cotfas and Petru Adrian Cotfas
Appl. Sci. 2024, 14(17), 7838; https://doi.org/10.3390/app14177838 - 4 Sep 2024
Abstract
In recent years, interest in renewable energy and photovoltaic systems has increased significantly. The design and implementation of photovoltaic systems are various, and they are in continuous development due to the technologies used. Photovoltaic systems are becoming increasingly complex due to the constantly [...] Read more.
In recent years, interest in renewable energy and photovoltaic systems has increased significantly. The design and implementation of photovoltaic systems are various, and they are in continuous development due to the technologies used. Photovoltaic systems are becoming increasingly complex due to the constantly changing needs of people, who are using more and more intelligent functions such as remote control and monitoring, power/energy prediction, and detection of broken devices. Advanced remote supervision and control applications use artificial intelligence approaches and expose photovoltaic systems to cyber threats. This article presents a detailed examination of the applications of various remote-control, artificial intelligence, and cybersecurity techniques across a diverse range of solar energy sources. The discussion covers the latest technological innovations, research outcomes, and case studies in the photovoltaics field, as well as potential challenges and the possible solutions to these challenges. Full article
(This article belongs to the Special Issue Advanced Forecasting Techniques and Methods for Energy Systems)
Show Figures

Figure 1

18 pages, 2336 KiB  
Article
Performance and Board Diversity: A Practical AI Perspective
by Lee-Wen Yang, Thi Thanh Binh Nguyen and Wei-Ju Young
Big Data Cogn. Comput. 2024, 8(9), 106; https://doi.org/10.3390/bdcc8090106 - 4 Sep 2024
Abstract
The face of corporate governance is changing as new technologies in the scope of artificial intelligence and data analytics are used to make better future-oriented decisions on performance management. This study attempts to provide empirical results to analyze when the impact of diversity [...] Read more.
The face of corporate governance is changing as new technologies in the scope of artificial intelligence and data analytics are used to make better future-oriented decisions on performance management. This study attempts to provide empirical results to analyze when the impact of diversity on the board of directors is most evident through the multi-breaks model and artificial neural networks. The input data for the simulation includes 853 electronic companies listed on the Taiwan Stock Exchange from 2000 to 2021. The empirical results show that the higher the percentage of female board members, the more influential the company’s performance is, which is only evident when the company is in good business condition. By integrating ANNs with multi-breakpoint regression, this study introduces a novel approach to management research, providing a detailed perspective on how board diversity impacts firm performance across different conditions. The ANN results show that using the number of business board members for predicting Return on Assets yields the highest accuracy, with female board members following closely in predictive effectiveness. The presence of women on the board contributes positively to ROA, particularly when the company is experiencing favorable business conditions and high profitability. Our analysis also reveals that a higher percentage of male board members improves company performance, but this benefit is observed only in highly favorable and unfavorable business conditions. Conversely, a higher percentage of business members tends to affect performance during periods of high profitability negatively. The power of the board of directors and significant shareholders is positively correlated with performance, whereas CEO power positively impacts performance only when it is not extremely low. Independent board members generally do not have a significant effect on profits. Additionally, the company’s asset value positively influences performance primarily when the return on assets is high, and increased financial leverage is associated with reduced profitability. Full article
(This article belongs to the Special Issue Machine Learning Applications and Big Data Challenges)
Show Figures

Figure 1

17 pages, 7640 KiB  
Article
Research on Designing Context-Aware Interactive Experiences for Sustainable Aging-Friendly Smart Homes
by Yi Lu, Lejia Zhou, Aili Zhang, Mengyao Wang, Shan Zhang and Minghua Wang
Electronics 2024, 13(17), 3507; https://doi.org/10.3390/electronics13173507 - 4 Sep 2024
Abstract
With the advancement of artificial intelligence, the home care environment for elderly users is becoming increasingly intelligent and systematic. The context aware human–computer interaction technology of sustainable aging-friendly smart homes can effectively identify user needs, enhance energy efficiency, and optimize resource utilization, thereby [...] Read more.
With the advancement of artificial intelligence, the home care environment for elderly users is becoming increasingly intelligent and systematic. The context aware human–computer interaction technology of sustainable aging-friendly smart homes can effectively identify user needs, enhance energy efficiency, and optimize resource utilization, thereby improving the convenience and sustainability of smart home care services. This paper reviews literature and analyzes cases to summarize the background and current state of context-aware interaction experience research in aging-friendly smart homes. Targeting solitary elderly users aged 60–74, the study involves field observations and user interviews to analyze their characteristics and needs, and to summarize the interaction design principles for aging-friendly smart homes. We explore processes for context-aware and methods for identifying user behaviors, emphasizing the integration of green, eco-friendly, and energy-saving principles in the design process. Focusing on the living experience and quality of life for elderly users living alone, this paper constructs a context-aware user experience model based on multimodal interaction technology. Using elderly falls as a case example, we design typical scenarios for aging-friendly smart homes from the perspectives of equipment layout and innovative hardware and software design. The goal is to optimize the home care experience for elderly users, providing theoretical and practical guidance for smart home services in an aging society. Ultimately, the study aims to develop safer, more convenient, and sustainable home care solutions. Full article
Show Figures

Figure 1

21 pages, 3696 KiB  
Article
The Potential of AI-Powered Face Enhancement Technologies in Face-Driven Orthodontic Treatment Planning
by Juraj Tomášik, Márton Zsoldos, Kristína Majdáková, Alexander Fleischmann, Ľubica Oravcová, Dominika Sónak Ballová and Andrej Thurzo
Appl. Sci. 2024, 14(17), 7837; https://doi.org/10.3390/app14177837 - 4 Sep 2024
Abstract
Improving one’s appearance is one of the main reasons to undergo an orthodontic therapy. While occlusion is important, not just for long-term stability, aesthetics is often considered a key factor in patient’s satisfaction. Following recent advances in artificial intelligence (AI), this study set [...] Read more.
Improving one’s appearance is one of the main reasons to undergo an orthodontic therapy. While occlusion is important, not just for long-term stability, aesthetics is often considered a key factor in patient’s satisfaction. Following recent advances in artificial intelligence (AI), this study set out to investigate whether AI can help guide orthodontists in diagnosis and treatment planning. In this study, 25 male and 25 female faces were generated and consequently enhanced using FaceApp (ver. 11.10, FaceApp Technology Limited, Limassol, Cyprus), one of the many pictures transforming applications on the market. Both original and FaceApp-modified pictures were then assessed by 441 respondents regarding their attractiveness, and the pictures were further compared using a software for picture analyses. Statistical analysis was performed using Chi-square goodness of fit test R Studio Studio (ver. 4.1.1, R Core Team, Vienna, Austria) software and the level of statistical significance was set to 0.05. The interrater reliability was tested using Fleiss’ Kappa for m Raters. The results showed that in 49 out of 50 cases, the FaceApp-enhanced pictures were considered to be more attractive. Selected pictures were further analyzed using the graphical software GIMP. The most prominent changes were observed in lip fullness, eye size, and lower face height. The results suggest that AI-powered face enhancement could be a part of the diagnosis and treatment planning stages in orthodontics. These enhanced pictures could steer clinicians towards soft-tissue-oriented and personalized treatment planning, respecting patients’ wishes for improved face appearance. Full article
(This article belongs to the Special Issue Artificial Intelligence in Medicine and Healthcare)
Show Figures

Figure 1

23 pages, 1089 KiB  
Article
Non-Negative Matrix Tri-Factorization for Representation Learning in Multi-Omics Datasets with Applications to Drug Repurposing and Selection
by Letizia Messa, Carolina Testa, Stephana Carelli, Federica Rey, Emanuela Jacchetti, Cristina Cereda, Manuela Teresa Raimondi, Stefano Ceri and Pietro Pinoli
Int. J. Mol. Sci. 2024, 25(17), 9576; https://doi.org/10.3390/ijms25179576 - 4 Sep 2024
Abstract
The vast corpus of heterogeneous biomedical data stored in databases, ontologies, and terminologies presents a unique opportunity for drug design. Integrating and fusing these sources is essential to develop data representations that can be analyzed using artificial intelligence methods to generate novel drug [...] Read more.
The vast corpus of heterogeneous biomedical data stored in databases, ontologies, and terminologies presents a unique opportunity for drug design. Integrating and fusing these sources is essential to develop data representations that can be analyzed using artificial intelligence methods to generate novel drug candidates or hypotheses. Here, we propose Non-Negative Matrix Tri-Factorization as an invaluable tool for integrating and fusing data, as well as for representation learning. Additionally, we demonstrate how representations learned by Non-Negative Matrix Tri-Factorization can effectively be utilized by traditional artificial intelligence methods. While this approach is domain-agnostic and applicable to any field with vast amounts of structured and semi-structured data, we apply it specifically to computational pharmacology and drug repurposing. This field is poised to benefit significantly from artificial intelligence, particularly in personalized medicine. We conducted extensive experiments to evaluate the performance of the proposed method, yielding exciting results, particularly compared to traditional methods. Novel drug–target predictions have also been validated in the literature, further confirming their validity. Additionally, we tested our method to predict drug synergism, where constructing a classical matrix dataset is challenging. The method demonstrated great flexibility, suggesting its applicability to a wide range of tasks in drug design and discovery. Full article
Show Figures

Figure 1

Back to TopTop