Search Results (41)

The skin serves as a critical barrier against external threats—dehydration, ultraviolet exposure, and infections—playing a significant role in internal homeostasis and moisture retention. Additionally, and equally importantly, it interacts dynamically with the complex microbiome resident in it, which is essential for maintaining skin health. Recent interest has focused on the use of probiotics and postbiotics, besides their ability to modulate the skin microbiome, to enhance barrier function, and exhibit anti-inflammatory properties, to be involved in skincare, by having the potential to improve skin hydration, elasticity, and overall appearance, as well as in reducing signs of aging, such as wrinkles and fine lines. The products—being a combination of a cosmetic regime plus probiotic[s] or postbiotic[s]—are named cosmeceuticals. However, to comply with the regulations for the characterization of a microorganism as a specific probiotic strain, the pro- or postbiotics incorporated into the cosmetic regime should be both genetically and phenotypically defined. Thus, in this review, we present 14 published clinical trials using such cosmetic products with specific, well-characterized strains of probiotics or postbiotics applied to volunteers with healthy skin. Looking at the results of these studies collectively, we can say that these genetically and phenotypically defined strains of either live or inanimate bacteria and/or their components seem to keep the treated skin at least fully hydrated, with intact epithelial tone, increased radiance, and with decreased wrinkle depth, while normalizing the commensal skin microbiota. Future advancements in personalized skin care may lead to genomic sequencing and metabolomics to tailor probiotic and postbiotic treatments to individual skin microbiomes, promising a new frontier in cosmeceuticals. Full article

Driven by the scientific objective of geophysical field detection and natural hazard monitoring from space, China launched an electromagnetic satellite, which is known as the China Seismo-Electromagnetic Satellite (CSES-01), on 2 February 2018, into a circular sun-synchronous orbit with an altitude of about 507 km in the ionosphere. The CSES-01 has been in orbit for over 6 years, successfully exceeding its designed 5-year lifespan, and will continually operate as long as possible. A second identical successor (CSES-02) will be launched in December 2024 in the same orbit space. The ionosphere is a highly dynamic and complicated system, and it is necessary to comprehensively understand the electromagnetic environment and the physical effects caused by various disturbance sources. The motivation of this report is to introduce the typical electromagnetic waves, mainly in the ELF/VLF band (i.e., ~100 Hz to 25 kHz), recorded by the CSES-01 in order to call the international community for deep research on EM wave activities and geophysical sphere coupling mechanisms. The wave spectral properties and the wave propagation parameters of those typical EM wave activities in the upper ionosphere are demonstrated in this study based on wave vector analysis using the singular value decomposition (SVD) method. The analysis shows that those typical and common natural EM waves in the upper ionosphere mainly include the ionospheric hiss and proton whistlers in the ELF band (below 1 kHz), the quasiperiodic (QP) emissions, magnetospheric line radiations (MLR), the falling-tone lightning whistlers, and V-shaped streaks in the ELF/VLF band (below 20 kHz). The typical artificial EM waves in the ELF/VLF band, such as power line harmonic radiation (PLHR) and radio waves in the VLF band, are also well recorded in the ionosphere. Full article

Health information systems (HISs) are essential information systems used by organisations and individuals for various purposes. Past research has studied different types of HIS, such as rostering systems, Electronic Medical Records (EMRs), and Personal Health Records (PHRs). Although several past confirmatory studies have quantitatively examined EMR uptake by health professionals, there is a lack of exploratory and qualitative studies that uncover various drivers of healthcare professionals’ uptake of EMRs. Applying an exploratory and qualitative approach, this study introduces various antecedents of healthcare professionals’ uptake of EMRs. This study conducted 78 semi-structured, open-ended interviews with 15 groups of healthcare professional users of EMRs in two large Australian hospitals. Data analysis of qualitative data resulted in proposing a framework comprising 23 factors impacting healthcare professionals’ uptake of EMRs, which are categorised into ten main categories: perceived benefits of EMR, perceived difficulties, hardware/software compatibility, job performance uncertainty, ease of operation, perceived risk, assistance society, user confidence, organisational support, and technological support. Our findings have important implications for various practitioner groups, such as healthcare policymakers, hospital executives, hospital middle and line managers, hospitals’ IT departments, and healthcare professionals using EMRs. Implications of the findings for researchers and practitioners are provided herein in detail. Full article

Health information systems (HISs) are instrumental in improving the efficiency and effectiveness of hospital operations, from managing patient data to enhancing decision-making processes. This study, which holds significant implications for the healthcare industry, aimed to identify the factors that influence users’ intentions to use HISs. The research involved interviews with healthcare professionals licensed to use the HIS of a public hospital. The survey, conducted in 2020, received 113 responses. Statistical methods of descriptive analysis, correlation, and multiple linear regression were used. Two models were examined. The first model investigated the relationship between the dependent variable of the intention to use an HIS and the independent variables of perceived time savings and perceived privacy protection. The second model explored the impact of age and education as control variables in the connection between the intention to use an HIS and time savings and privacy protection. A significant moderate positive correlation was found between the intention to use an HIS and perceived time savings, while a significant weak positive correlation was detected between the intention to use an HIS and education. Regression analysis in the first model revealed a significant connection between the intention to use an HIS and perceived time savings. However, the perceived privacy protection variable did not show a significant relationship with the dependent variable. The second model showed statistical significance in the relationship between the intention to use an HIS and education, but not with the second control variable, age. It can be concluded that education strengthens the positive impact of perceived time savings on the intention to use a health information system (HIS), a finding that has immediate and practical implications for healthcare professionals and researchers in the field of health information systems and healthcare management, underlining the importance of this research in advancing the understanding and adoption of HISs in healthcare settings. Full article

Water electrolysis to generate green hydrogen is the key to decarbonization. Tracking the state-of-health of electrolyzers is fundamental to ensuring their economical and safe operation. This paper addresses the challenge of quantifying the state-of-health of electrolyzers, which is complicated by the influence of operating conditions. The existing approaches require stringent control of operating conditions, such as following a predefined current profile and maintaining a constant temperature, which is impractical for industrial applications. We propose a data-driven method that corrects the measured voltage under arbitrary operating conditions to a reference condition, serving as a state-of-health indicator for electrolyzers. The method involves fitting a voltage model to map the relationship between voltage and operating conditions and then using this model to calculate the voltage under predefined reference conditions. Our approach utilizes an empirical voltage model, validated with actual industrial electrolyzer operation data. We further introduce a transfer linear regression algorithm to tackle model fitting difficulties with limited data coverage. Validation on synthetic data confirms the algorithm’s effectiveness in capturing the true model coefficients, and application on actual operation data demonstrates its ability to provide stable state-of-health estimations. This research offers a practical solution for the industry to continuously monitor electrolyzer degradation without the need for stringent control of operating conditions. Full article

The role of the epidermal growth factor receptor (EGFR) in tumor progression and survival is often underplayed. Its expression and/or dysregulation is associated with disease advancement and poor patient outcome as well as drug resistance in breast cancer. EGFR is often overexpressed in breast cancer and particularly triple-negative breast cancer (TNBC), which currently lacks molecular targets. We examined the synergistic potential of an EGFR inhibitor (EGFRi) in combination with doxorubicin (Dox) in estrogen-positive (ER+) MCF-7 and MDA-MB-231 TNBC cell lines. The exposure of MDA-MB-231 and MCF-7 to EGFRi produced an IC_50s of 6.03 µM and 3.96 µM, respectively. Dox induced MDA-MB-231 (IC₅₀ 9.67 µM) and MCF-7 (IC₅₀ 1.4 µM) cytotoxicity. Combinations of EGFRi-Dox significantly reduced the IC₅₀ in MCF-7 (0.46 µM) and MBA-MB 231 (0.01 µM). Synergistic drug interactions in both cell lines were confirmed using the Bliss independence model. Pro-apoptotic Caspase-3/7 activation occurred in MCF-7 at 0.1–10 µM of EGFRi and Dox single treatments, whilst 1 μM Dox yielded a more potent effect on MDA-MB-231. EGFRi and Dox individually and in combination downregulated the EGFR gene expression in MCF-7 and MDA-MB-231 (p < 0.001). This study demonstrates EGFRi’s potential for eliciting synergistic interactions with Dox, causing enhanced growth inhibition, apoptosis induction, and downregulation of EGFR in both cell lines. Full article

This study aimed to determine the impact of various pressures on the functional composition of OCH (Odonata, Coleoptera, and Heteroptera) in streams within the northwest Rif region of Morocco. We examined how OCH traits respond to human-induced pressures in selected stream sites in Morocco’s northwestern Rif region. OCH specimens were collected from 36 sites using a Surber sampler with dimension of 20 × 20 cm and mesh size of 500 µm over the course of two years, from 2021 to 2023. We measured physico-chemical and hydraulic parameters such as temperature, pH, DO, and NO-3. Sixty-seven trait attributes from 11 trait classes were assigned to the collected OCH taxa at the family level. Following the delineation of sites along the gradient of impacts in the study area, we categorized 7 sites as slightly impacted sites (SISs), 19 sites as moderately impacted sites (MISs), and 10 sites as heavily impacted sites (HISs). We successfully identified and categorized the traits as either vulnerable or tolerant based on RLQ models. Traits such as reproductive cycles per year and tegument respiration, which were positively correlated with SISs in the RLQ model and also positively correlated with depth and chlorine, were identified as vulnerable traits. Crawling locomotion and full water swimming were identified as tolerant traits. The distribution patterns of the OCH taxa revealed a robust correlation between the taxa and the sampling sites. Notably, taxa such as Nepidae, Naucoridae, and Corixidae exhibited widespread distribution and a strong association with the SISs. On the other hand, traits related to living macroinvertebrate food sources and reproduction in vegetation, specifically clutches, exhibited a negative correlation with total dissolved solids. Incorporating OCH functional traits into biomonitoring programs allows for a more comprehensive assessment of river ecosystems. This approach provides a nuanced understanding of how different stressors impact the community composition and overall ecological health. Full article

The Human Interference Scoring System (HISS) is a novel food-based diet-quality-classification system based on the existing NOVA method. HISS involves food and fluid allocation into categories from digital imagery based on food processing levels, followed by meal plan analysis using food-servings quantification. The primary purpose of this work was to evaluate the reliability of HISS. Trained nutrition professionals analyzed digital photographs from five hypothetical 24 h food recalls and categorized foods into one of four HISS categories. A secondary purpose was to assess the nutrient composition of the food recalls and other selected foods from the HISS categories. Participants effectively categorized foods into HISS categories, with only minor discrepancies noted. High inter-rater reliability was observed in the outer HISS categories: unprocessed and ultra-processed foods. Ultra-processed items consistently displayed elevated energy, carbohydrates, and sugar compared to unprocessed foods, while unprocessed foods exhibited notably higher dietary fiber. This study introduces the HISS as a potentially useful tool for quantifying a food-quality-based system using digital-photography-based assessments. Its high inter-rater reliability and ability to capture relationships between food processing levels and nutrient composition make it a promising method for assessing dietary habits and food quality. Full article

Health information systems (HISs) have immense value for healthcare institutions, as they provide secure storage, efficient retrieval, insightful analysis, seamless exchange, and collaborative sharing of patient health information. HISs are implemented to meet patient needs, as well as to ensure the security and privacy of medical data, including confidentiality, integrity, and availability, which are necessary to achieve high-quality healthcare services. This systematic literature review identifies various technologies and methods currently employed to enhance the security and privacy of medical data within HISs. Various technologies have been utilized to enhance the security and privacy of healthcare information, such as the IoT, blockchain, mobile health applications, cloud computing, and combined technologies. This study also identifies three key security aspects, namely, secure access control, data sharing, and data storage, and discusses the challenges faced in each aspect that must be enhanced to ensure the security and privacy of patient information in HISs. Full article

Objective: In the age of digital transformation, there is a need for a sustainable information management vision in health. Understanding the accumulation of health information management (HIM) knowledge from the past to the present and building a new vision to meet this need reveals the importance of understanding the available scientific knowledge. With this research, it is aimed to examine the scientific documents of the last 40 years of HIM literature with a holistic approach using science mapping techniques and to guide future research. Methods: This study used a bibliometric analysis method for science mapping. Co-citation and co-occurrence document analyses were performed on 630 academic publications selected from the Web of Science core collection (WoSCC) database using the keyword “Health Information Management” and inclusion criteria. The analyses were performed using the R-based software Bibliometrix (Version 4.0; K-Synth Srl), Python (Version 3.12.1; The Python Software Foundation), and Microsoft^® Excel^® 2016. Results: Co-occurrence analyses revealed the themes of personal health records, clinical coding and data quality, and health information management. The HIM theme consisted of five subthemes: “electronic records”, “medical informatics”, “e-health and telemedicine”, “health education and awareness”, and “health information systems (HISs)”. As a result of the co-citation analysis, the prominent themes were technology acceptance, standardized clinical coding, the success of HISs, types of electronic records, people with HIM, health informatics used by consumers, e-health, e-mobile health technologies, and countries’ frameworks and standards for HISs. Conclusions: This comprehensive bibliometric study shows that structured information can be helpful in understanding research trends in HIM. This study identified critical issues in HIM, identified meaningful themes, and explained the topic from a holistic perspective for all health system actors and stakeholders who want to work in the field of HIM. Full article

Lizards, except geckos, are generally considered voiceless organisms, although some species emit oral sounds. For most of these “vocal lizards”, however, there is almost no information on the characteristics of the sounds, precluding exploration of the functionality and evolution of the sounds. Pristidactylus are known as “grunter lizards” since individuals emit oral sounds under predation risk. We explored the characteristics of the sounds emitted by P. valeriae, recording 17 adults and 1 juvenile when they were threatened and captured by a predator. Only adults emitted sounds with open mouths and displayed aggressive postures, e.g., biting attempts. These sounds correspond to hisses, which lack amplitude or frequency modulation. The lizards emitted longer hisses when threatened than when captured by the predator, which may provide honest information on individuals’ ability to escape. In addition, males may experience higher distress during threats since their hisses had higher aggregate entropy than those of the females. Finally, hissing has been documented in four of the five Leiosauridae genera, the family to which Pristidactylus belongs, suggesting that sound emission is ancestral to the family. Full article

Aims: This article aims to perform a Systematic Literature Review (SLR) to better understand the structures of different methods, techniques, models, methodologies, and technologies related to provenance data management in health information systems (HISs). The SLR developed here seeks to answer the questions that contribute to describing the results. Method: An SLR was performed on six databases using a search string. The backward and forward snowballing technique was also used. Eligible studies were all articles in English that presented on the use of different methods, techniques, models, methodologies, and technologies related to provenance data management in HISs. The quality of the included articles was assessed to obtain a better connection to the topic studied. Results: Of the 239 studies retrieved, 14 met the inclusion criteria described in this SLR. In order to complement the retrieved studies, 3 studies were included using the backward and forward snowballing technique, totaling 17 studies dedicated to the construction of this research. Most of the selected studies were published as conference papers, which is common when involving computer science in HISs. There was a more frequent use of data provenance models from the PROV family in different HISs combined with different technologies, among which blockchain and middleware stand out. Despite the advantages found, the lack of technological structure, data interoperability problems, and the technical unpreparedness of working professionals are still challenges encountered in the management of provenance data in HISs. Conclusion: It was possible to conclude the existence of different methods, techniques, models, and combined technologies, which are presented in the proposal of a taxonomy that provides researchers with a new understanding about the management of provenance data in HISs. Full article

Radiation dose tracking is becoming very important due to the popularity of computerized tomography (CT) scans. One of the challenges of radiation dose tracking is that there are several variables that affect the dose from the patient side, machine side, and procedures side. Although some tracking software programs exists, they are based on static analysis and cause integration errors due to the heterogeneity of Hospital Information Systems (HISs) and prevent users from obtaining accurate answers to their questions. In this paper, a visual analytic approach is utilized to track radiation dose data from computed tomography (CT) through the use of Tableau data visualization software. The web solution is evaluated in real-life scenarios by domain experts. The results show that the visual analytics approach improves the tracking process, as users completed the tasks with a 100% success rate. The process increased user satisfaction and also provided invaluable insight into the analytical process. Full article

Tinnitus is originally derived from the Latin verb tinnire, which means “to ring”. Tinnitus, a complex disorder, is a result of sentient cognizance of a sound in the absence of an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to a hissing and ringing in the ear. Surgical interventions and many other forms of treatment have been only partially effective due to heterogeneity in tinnitus patients and a lack of understanding of the mechanisms of tinnitus. Although researchers across the globe have made significant progress in understanding the underlying mechanisms of tinnitus over the past few decades, tinnitus is still deemed to be a scientific enigma. This review summarises the role of the limbic system in tinnitus development and provides insight into the development of potential target-specific tinnitus therapies. Full article

The black grouse is a species whose population development requires constant monitoring due to a rapidly declining trend, especially in Central Europe. Variability in the voices of geographically separated populations can aid in counting within individual populations. This has been investigated with the black grouse. However, the variability of the acoustic behavior of black grouse between populations was investigated for the first time. In total, 82 male black grouse were recorded during the lekking season in four countries: the Czech Republic, Scotland, Finland, and Russia. We analyzed recordings of hissing calls, i.e., the non-vocal signal. DFA analysis correctly classified almost 70% of the recordings. The results indicate a certain degree of difference between the grouse populations from the four countries examined. The mean frequency of hissing calls for populations was 1410.71 ± 170.25 Hz, 1473.89 ± 167.59 Hz, 1544.38 ± 167.60 Hz, and 1826.34 ± 319.23 Hz in the Czech Republic, Finland, Russia, and Scotland, respectively. Populations from Scotland and Russia have greater intra-variability compared to grouse from the Czech Republic and Finland, indicating that population density is not the principal factor in the geographical variability of black grouse hissing calls. Range-level differences enhance knowledge and facilitate the assessment of species evolution. Full article