Search Results (4,745)

To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed and prepared for ROS-triggered on-demand doxorubicin (DOX) release. A rationally designed amphiphilic block copolymer, poly(ethylene glycol)-b-poly(diselenolane diol-co-isophorone diisocyanate)-b-poly(ethylene glycol) (PEG-b-PUSe-b-PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through the polycondensation reaction. In aqueous media, this type of amphiphilic block copolymer can self-assemble into micellar aggregates and encapsulate DOX within the micellar core, forming DOX-loaded micelles that are subsequently in situ core-crosslinked by diselenides via a visible-light-triggered metathesis reaction of Se-Se bonds. Compared with the non-crosslinked micelles (NCLMs), the as-prepared diselenide-crosslinked micelles (CLMs) exhibited a smaller particle size and improved colloidal stability. In vitro release studies have demonstrated suppressed drug release behavior for CLMs in physiological conditions, as compared to the NCLMs, whereas a burst release of DOX occurred upon exposure to an oxidation environment. Moreover, MTT assay results have revealed that the crosslinked polyurethane micelles displayed no significant cytotoxicity towards HeLa cells. Cellular uptake analyses have suggested the effective internalization of DOX-loaded crosslinked micelles and DOX release within cancer cells. These findings suggest that this kind of ROS-triggered reversibly crosslinked polyurethane micelles hold significant potential as a ROS-responsive drug delivery system. Full article

Magnetic Fe₃O₄ nanoparticles (MNPs) functionalized with (3-aminopropylo)trietoksysilan (APTES) or N-carboxymethylchitosan (CMC) were proposed as nanocarriers of methotrexate (MTX) to target ovarian cancer cell lines. The successful functionalization of the obtained nanostructures was confirmed by FT-IR spectroscopy. The nanoparticles were characterized by transmission electron spectroscopy (TEM) and dynamic light scattering (DLS) techniques. Their potential zeta, magnetization, and hyperthermic properties were also explored. MTX was conjugated with the nanocarriers by ionic bonds or by amide bonds. The drug release kinetics were examined at different pH and temperatures. The MTT assay showed no toxicity of the MNPs[APTES] and MNPs[CMC]. Finally, the cytotoxicity of the nanostructures with MTX attached towards the ovarian cancer cells was measured. The sensitivity and resistance to methotrexate was determined in simplistic 2D and spheroid 3D conditions. The cytotoxicity tests of the tested nanostructures showed similar values for inhibiting the proliferation of ovarian cancer cells as methotrexate in its free form. Conjugating MTX with nanoparticles allows the drug to be directed to the target site using an external magnetic field, reducing overall toxicity. Combining this approach with hyperthermia could enhance the therapeutic effect in vivo compared to free MTX, though further research on advanced 3D models is needed. Full article

In this paper, we propose an innovative light-powered LCE-slider system that enables continuous self-circling on an elliptical track and is comprised of a light-powered LCE string, slider, and rigid elliptical track. By formulating and solving dimensionless dynamic equations, we explain static and self-circling states, emphasizing self-circling dynamics and energy balance. Quantitative analysis reveals that the self-circling frequency of LCE-slider systems is independent of the initial tangential velocity but sensitive to light intensity, contraction coefficients, elastic coefficients, the elliptical axis ratio, and damping coefficients. Notably, elliptical motion outperforms circular motion in angular velocity and frequency, indicating greater efficiency. Reliable self-circling under constant light suggests applications in periodic motion fields, especially celestial mechanics. Additionally, the system’s remarkable adaptability to a wide range of curved trajectories exemplifies its flexibility and versatility, while its energy absorption and conversion capabilities position it as a highly potential candidate for applications in robotics, construction, and transportation. Full article

This paper reports the designing and testing, as well as the processing and testing, of a flexible piezoresistive sensor for pressure-sensing applications, utilizing a composite film of graphene/polyvinylidene fluoride (Gr/PVDF). Graphene serves as the conductive matrix, while PVDF acts as both the binder and a flexible polymer matrix. The composite film was fabricated using the solution casting technique on a flexible polyethylene substrate. We investigated the impact of post-infrared annealing on the pressure response of the Gr/PVDF films. The experimental results indicated that the films IR-annealed for 2 min exhibited improved pressure sensitivity compared with the as-deposited films. The stability and durability of the sensors were assessed through the application of pressure over more than 1000 cycles. The mechanical properties of the films were examined using a universal tensile testing machine (UTM) for scenarios both with and without infrared light annealing. Raman spectroscopy was employed to analyze the quality and characteristics of the prepared nanocomposites. This study enhances our understanding of the interplay between the Gr/PVDF composite, the IR annealing effect, and the hysteresis effect in the pressure-sensing mechanism, thereby improving the piezoresistance of the Gr/PVDF nanocomposite through the infrared annealing process. Full article

In this study, a hollow tubulous-shaped In₂O₃ derived from MIL (MIL-68 (In)) exhibited an enhanced specific surface area compared to MIL. To further sensitize In₂O₃, ZnIn₂S₄ was grown in situ on the derived In₂O₃. The 40In₂O₃/ZnIn₂S₄ composite (1 mmol ZnIn₂S₄ loaded on 40 mg In₂O₃) exhibited degradation rates of methyl orange (MO) under visible light (80 mW·cm⁻², 150 min) that were 17.9 and 1.4 times higher than those of the pure In₂O₃ and ZnIn₂S₄, respectively. Moreover, the 40In₂O₃/ZnIn₂S₄ exhibited an obviously improved antibacterial performance against Pseudomonas aeruginosa, with an antibacterial rate of 99.8% after visible light irradiation of 80 mW cm⁻² for 420 min. The 40In₂O₃/ZnIn₂S₄ composite showed the highest photocurrent density, indicating an enhanced separation of photogenerated charge carriers. Electron spin resonance results indicated that the 40In₂O₃/ZnIn₂S₄ composite generated both ·O₂⁻ and ·OH radicals under visible light, whereas ·OH radicals were almost not detected in ZnIn₂S₄ alone, suggesting the presence of a Z-scheme heterojunction between In₂O₃ and ZnIn₂S₄, thereby enhancing the degradation and antibacterial capabilities of the composite. This offers fresh perspectives on designing effective photocatalytic materials for use in antibacterial and antifouling applications. Full article

The pH- and thermo-responsive behavior of polymeric hydrogels $\left({\mathrm{M}}_{\mathrm{C}}-\mathrm{c}\mathrm{o}-{\mathrm{M}}_{\mathrm{A}}\right)$ have been studied in detail using dynamic light scattering $\left(\mathrm{D}\mathrm{L}\mathrm{S}\right)$, scanning electron microscopy$\left(\mathrm{S}\mathrm{E}\mathrm{M}\right)$, nuclear magnetic resonance (¹H NMR) and rheology to evaluate the conformational changes, swelling–shrinkage, stability, the ability to flow and the diffusion process of nanoparticles at several temperatures. Furthermore, polymeric systems functionalized with acrylic acid $\left({\mathrm{M}}_{\mathrm{C}}\right)$ and acrylamide $\left({\mathrm{M}}_{\mathrm{A}}\right)$ were subjected to a titration process with a calcium chloride $\left({\mathrm{C}\mathrm{a}\mathrm{C}\mathrm{l}}_2\right)$ solution to analyze its effect on the average particle diameter$\left({\mathrm{D}}_{\mathrm{z}}\right)$, polymer structure and the intra- and intermolecular interactions in order to provide a responsive polymer network that can be used as a possible nanocarrier for drug delivery with several benefits. The results confirmed that the structural changes in the sensitive hydrogels are highly dependent on the corresponding critical solution temperature $\left(\mathrm{C}\mathrm{S}\mathrm{T}\right)$ of the carboxylic (–COOH) and amide (–CONH₂) functional groups and the influence of calcium ions $\left({\mathrm{C}\mathrm{a}}^{2+}\right)$ on the formation or breaking of hydrogen bonds, as well as the decrease in electrostatic repulsions generated between the polymer chains contributing to a particle agglomeration phenomenon. The temperature leads to a re-arrangement of the polymer chains, affecting the viscoelastic properties of the hydrogels. In addition, the diffusion coefficients $\left(D\right)$ of nanoparticles were evaluated, showing a closeness among with the morphology, shape, size and temperature, resulting in slower diffusions for larger particles size and, conversely, the diffusion in the medium increasing as the polymer size is reduced. Therefore, the hydrogels exhibited a remarkable response to pH and temperature variations in the environment. During this research, the functionality and behavior of the polymeric nanoparticles were observed under different analysis conditions, which revealed notable structural changes and further demonstrated the nanoparticles promising high potential for drug delivery applications. Hence, these results have sparked significant interest in various scientific, industrial and technological fields. Full article

Data on the soil nutrient content are required to calculate fertilizer rate recommendations. The soil laboratory determines these soil properties, yet the measurement is time-consuming and costly. Meanwhile, portable devices to assess the soil nutrient content in real-time are limited. However, a proprietary and low-cost NPK sensor is available and commonly used in IoT for agriculture. This study aimed to assemble and test a portable, NPK sensor-based device in irrigated and rainfed paddy soils from Java, Indonesia. The device development followed a prototyping approach. The device building included market surveys and opted for an inexpensive, light, and compact soil sensor, power storage, monitor, and wire connectors. Arduino programming language was used to write scripts for data display and sub-device communication. The result is a real-time, portable soil nutrient detector that measures the soil temperature, moisture, pH, electrical conductivity, and N, P, and K contents. Field tests show that the device is sensitive to soil properties and location. The portable soil nutrient detector may be an alternative tool for the real-time measurement of soil nutrients in paddy fields in Indonesia. Full article

The fluorescence decays (FDs) of 27 dried vegetative bacteria, bacterial endospores, fungi, and pollens were measured and determined using a stroboscopic technique. Pulsed nanosecond LED sources, emitting light at wavelengths of 280, 340, and 460 nm, were used for the excitation of biological samples. The implicit advantages of the stroboscopic method are high sensitivity, speed of a single measurement (10–60 s), miniaturization of the device, and relatively low price compared to the typical lifetime methods. The Principal Component Analysis (PCA) method was used for chemometric analysis. It was found that the excitation at 340, 460, and data merged from 340 and 460 nm effectively separate individual groups of biological substances. These findings provide evidence that fluorescence decay data may allow the classification of the biological samples, and the FDs measurement method can be complementary to the study of fluorescence spectra. Full article

This paper presents a novel approach to studying divorce dynamics and elimination strategies using nonlinear differential equations. A mathematical model is formulated to capture the key factors influencing divorce rates. The model undergoes a rigorous theoretical analysis, including parameter estimation, solution existence/uniqueness, positivity, boundedness, and invariant regions. A qualitative analysis explores equilibria, stability conditions, and a sensitivity analysis. Numerical simulations and discussions are presented to validate the model and shed light on divorce dynamics. Finally, conclusions and future research directions are outlined. This work offers valuable insights for understanding and potentially mitigating divorce rates through targeted interventions. Full article

The advancement of emission reduction benefits in ridesplitting relies on a comprehensive carbon reduction incentive policy initiated by the government and implemented through the collaborative efforts of multiple stakeholders. The aim of this study is to understand the implementation mechanism and explore the carbon reduction potential of the Carbon-Inclusive Policy. A framework has been developed to explore an evolutionary stabilization strategy through a three-party evolutionary game model, which considers the crucial stakeholders of the government, shared mobility companies, and travelers. A comprehensive sensitivity analysis has been conducted across various scenarios on key factors to ensure the robustness and accuracy of findings. The study’s primary findings indicate that the government’s level of commitment to the Carbon-Inclusive Policy significantly influences strategic decisions and the pace of evolution among the three stakeholders in the evolutionary game. Companies critically assess the economic viability of ridesplitting, particularly in light of development costs and subsidy incentives. Government backing and increased ridesplitting adoption by travelers serve to mitigate risks, incentivizing companies to actively promote ridesplitting. Furthermore, the study emphasizes the necessity of balancing individual, company, and societal interests for sustainable transportation development, advocating for reasonable carbon tax credits and the promotion of novel development concepts such as Environmental, Social, and Governance (ESG) principles. These findings serve as a significant resource for policymakers navigating the complexities of integrating carbon considerations into transportation policy frameworks, contributing to a deeper theoretical understanding of Carbon-Inclusive Policy implementation in the sector. Full article

A novel demodulation scheme for a point-type fiber sensor is designed for salinity concentration monitoring based on a Sagnac interferometer (SI) composed of a tapered polarization-maintaining fiber (TPMF) and optical time stretching technology. The SI, constructed using a PMF with a taper region of 5.92 μm and an overall length of 30 cm, demonstrated a notable enhancement in the evanescent field, which intensifies the interaction between the light field and external salinity. This enhancement allows for a direct assessment of salinity concentration changes by analyzing the variations in the SI reflection spectra and the experimental results indicate that the sensitivity of the sensor is 0.151 nm/‰. In contrast to traditional fiber optic sensors that depend on spectral demodulation with slower response rates, this work introduces a new approach where the spectral shift is translated to the time domain, utilizing a dispersion compensation fiber (DCF) with the demodulation rate reaching up to 50 MHz. The experimental outcomes reveal that the sensor exhibits a sensitivity of −0.15 ns/‰ in the time domain. The designed sensor is anticipated to play a pivotal role in remote, real-time monitoring of ocean salinity. Full article

Soil organic carbon (SOC) plays a vital role in the global carbon cycle and soil quality assessment. The Qinghai–Tibet Plateau is one of the largest plateaus in the world. Therefore, in this region, SOC density and the spatial distribution of SOC are highly sensitive to climate change and human intervention. Given the insufficient understanding of the spatial distribution of SOC density in the Qinghai–Tibet Plateau, this study utilized machine learning (ML) algorithms to estimate the density and distribution pattern of SOC density in the region. In this study, we first collected multisource data, such as optical remote sensing data, synthetic aperture radar) (SAR) data, and other environmental variables, including socioeconomic factors, topographic factors, climate factors, and soil properties. Then, we used ML algorithms, namely random forest (RF), extreme gradient boosting (XGBoost), and light gradient boosting machine (LightGBM), to estimate the topsoil SOC density and spatial distribution patterns of SOC density. We also aimed to investigate any driving factors. The results are as follows: (1) The average SOC density is 5.30 kg/m². (2) Among the three ML algorithms used, LightGBM showed the highest validation accuracy (R² = 0.7537, RMSE = 2.4928 kgC/m², MAE = 1.7195). (3) The normalized difference vegetation index (NDVI), valley depth (VD), and temperature are crucial in predicting the spatial distribution of topsoil SOC density. Feature importance analyses conducted using the three ML models all showed these factors to be among the top three in importance, with contribution rates of 14.08%, 12.29%, and 14.06%; 17.32%, 20.73%, and 24.62%; and 16.72%, 11.96%, and 20.03%. (4) Spatially, the southeastern part of the Qinghai–Tibet Plateau has the highest topsoil SOC density, with recorded values ranging from 8.41 kg/m² to 13.2 kg/m², while the northwestern part has the lowest density, with recorded values ranging from 0.85 kg/m² to 2.88 kg/m². Different land cover types showed varying SOC density values, with forests and grasslands having higher SOC densities compared to urban and bare land areas. The findings of this study provide a scientific basis for future soil resource management and improved carbon sequestration accounting in the Qinghai–Tibet Plateau. Full article

This study examined the effects of low-temperature heat treatment on the characteristics of the rubies from Mong Hsu, Myanmar. Five ruby samples were heated to 400, 600, 900 and 1200 °C for different durations, respectively. Before and after each heating step, a visual examination was conducted with a gem microscope under different illumination conditions. Various spectral analyses such as UV-Vis, FTIR, Raman and PL were also used to examine the effect of heating on the ruby samples. The low-temperature heat treatment enhanced the ruby samples by causing the dark blue core to partially or completely fade away. It then increased the overall light transmittance and enhanced the fluorescence peak around 694 nm but did not improve the red hue of the samples. Two major changes were found in the experiments. One was the dark blue core of the samples that faded as the heating temperature increased. They were verified by the spectra to be the variation in the intervalence charge transfer between Fe²⁺ and Ti⁴⁺. The variation in the intervalence charge transfer of Mong Hsu ruby was not noticeable before heating to 900 °C but changed dramatically when heated to 1200 °C. The other was the shift of the FTIR peak, which is caused by decomposition of minerals due to heating. An FTIR 630 cm⁻¹ peak proved to be sensitive to the low-temperature heating and might be helpful for detecting low-temperature treatment. Full article

Nickel silicides are crucial in advanced technology applications ranging from semiconductor devices to high-temperature materials. Gas atomization is a process that involves the formation of fine liquid droplets and their rapid cooling and solidification to make powder particles. The final microstructure and the properties of the particles are highly sensitive to the gas atomization process parameters. In the present study, gas atomization of NiSi12-wt% was performed at three different pressures (35, 40, and 45 bars) to optimize the particle size distribution for additive manufacturing applications. A comprehensive range of characterization techniques, including scanning electron microscopy, X-ray diffraction, particle size distribution measurements, light optical microscopy, and density measurements, was used to evaluate the microstructural features, phase composition, and density of the produced NiSi12-wt% powders. Higher atomizing gas pressures resulted in a finer particle size distribution due to improved molten droplet breakup, increased satellite formation, and a well-suited particle size distribution for additive manufacturing applications. Full article

Despite advances in conservation–restoration treatments, most surface cleaning tests are subjectively evaluated. Scores according to qualitative criteria are employed to assess results, but these can vary by user and context. This paper presents a range of cleaning efficacy and homogeneity evaluation metrics for appraising cleaning trials, which minimise user bias by measuring quantifiable changes in the appearance and characteristic spectral properties of surfaces. The metrics are based on various imaging techniques (optical imaging by photography using visible light (VIS); spectral imaging in the visible-to-near-infrared (VNIR) and shortwave infrared (SWIR) ranges; chemical imaging by Fourier transform infrared (FTIR) spectral mapping in the mid-infrared (MIR) range; and scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDX) element mapping). They are complemented by appearance measurements (glossimetry and colourimetry). As a case study showcasing the low-cost to high-end metrics, agar gel spray cleaning tests on exposed ground and unvarnished oil paint mock-ups are reported. The evaluation metrics indicated that spraying agar (prepared with citric acid in ammonium hydroxide) at a surface-tailored pH was as a safe candidate for efficacious and homogenous soiling removal on water-sensitive oil paint and protein-bound ground. Further research is required to identify a gel-based cleaning system for oil-bound grounds. Full article