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23 pages, 20317 KiB  
Article
Research on the Unsteady Flow Characteristics of Solid–Liquid Two-Phase Flow in a Deep-Sea Mining Lift Pump and Model Experimental Verification
by Shunjun Hong, Junhong Hu, Pengyun Wei, Haizhong Man, Zihai Yang, Jing Wu and Xiaozhou Hu
J. Mar. Sci. Eng. 2024, 12(9), 1611; https://doi.org/10.3390/jmse12091611 - 10 Sep 2024
Abstract
The deep-sea mining lift pump is one of the pivotal components in deep-sea mineral transportation systems and its internal flow is very complex; consequently, unraveling its unsteady flow behavior pattern holds immense practical value. This study adopts numerical methods to analyze the time-averaged [...] Read more.
The deep-sea mining lift pump is one of the pivotal components in deep-sea mineral transportation systems and its internal flow is very complex; consequently, unraveling its unsteady flow behavior pattern holds immense practical value. This study adopts numerical methods to analyze the time-averaged distribution characteristics of the internal flow field in mining lift pumps, as well as the flow field’s pulsation intensity distribution characteristics, the vortex’s spatiotemporal evolution process in both moving and static cascades, and the time- and frequency-domain pulsation characteristics of internal pressure in each flow passage component under four different flow conditions are also investigated. The hydraulic properties of mining lift pumps under these four different conditions are also evaluated, and the outcomes are benchmarked against those of numerical predictions. Our findings reveal that the interplay between impeller blades and guide vanes significantly influences the pump’s flow characteristics, with the pump’s unsteady flow influencing its hydraulic properties. Experimental validation of this system confirms that the pump under study is in line with design specifications in terms of hydraulic properties. The method validation test on the prototype pump shows that the SST k-ω model is capable of successfully forecasting instability in the flow features of deep-sea mining lift pumps. These results will serve as a theoretical reference for regulating the flow state inside deep-sea mining lift pumps. Full article
(This article belongs to the Special Issue Deep-Sea Mining Technologies: Recent Developments and Challenges)
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15 pages, 2293 KiB  
Article
A Hydroponic System to Study the Effects of Root and Meristem Night Temperature on Growth, Photosynthesis Carbon Balance, and Antioxidant Enzymes in Rice
by Alejandro J. Pieters, Sabine Stürz, Julia Asch and Folkard Asch
Agriculture 2024, 14(9), 1574; https://doi.org/10.3390/agriculture14091574 - 10 Sep 2024
Abstract
Nocturnal root and meristem temperature (RMT) can have a strong effect on rice growth and yield. However, underlying mechanisms are not well understood. To investigate the effects of night-time RMT on photosynthesis biomass allocation and activities of antioxidant enzymes, we designed a hydroponic [...] Read more.
Nocturnal root and meristem temperature (RMT) can have a strong effect on rice growth and yield. However, underlying mechanisms are not well understood. To investigate the effects of night-time RMT on photosynthesis biomass allocation and activities of antioxidant enzymes, we designed a hydroponic system that maintained the following daily patterns of day/night temperature: 18/28 °C (HNT) or 28/18 °C (LNT). Rice plants cv. IR64 were grown in the greenhouse and subjected to either HNT or LNT. HNT stimulated growth and tillering but did not affect biomass allocation. HNT plants increased total biomass by 16 and 35%, depending on time of exposure. HNT increased rates of photosynthesis (Pn) compared to LNT plants in leaves of different ages. Overnight carbohydrate remobilisation was larger in HNT than in LNT plants, particularly at 16 days after treatment (dat), when Pn and relative growth rates were highest. Leaf soluble protein concentrations and specific leaf area were not affected by RMT, indicating higher photosynthetic nitrogen use efficiency in HNT plants. Super Oxide Dismutase, Ascorbate Peroxidase, and Glutathione Reductase activities did not respond to RMT, indicating no change in the production of reactive oxygen species in LNT plants despite lower photosynthesis rates. HNT increased sink demand by stimulating tillering, the increased sink demand upregulated the source activity through a larger leaf area per plant and a higher Pn throughout the canopy. The hydroponic system described here was able to control the temperature of the nutrient solution effectively, the installation of a second pump directly circulating the nutrient solution from and back to the reservoir through the cooling system allowed reaching the target temperature within 1 h. This system opens new opportunities to characterise plant responses to RMT alone or in combination with other environmental drivers. Full article
(This article belongs to the Special Issue Innovative Hydroponic Systems for Sustainable Agriculture)
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20 pages, 8894 KiB  
Article
Impact of Double-Suction Pump Eye Diameter Variation on Cavitation Phenomena
by Kyungseok Oh and Junho Kim
Machines 2024, 12(9), 633; https://doi.org/10.3390/machines12090633 - 10 Sep 2024
Abstract
Cavitation phenomena in pumps are major determinants of the lifespan of both the impeller and the pump itself, causing significant vibration and noise, which are critical concerns for pump designers. This study focuses on the influence of various geometric factors of the impeller, [...] Read more.
Cavitation phenomena in pumps are major determinants of the lifespan of both the impeller and the pump itself, causing significant vibration and noise, which are critical concerns for pump designers. This study focuses on the influence of various geometric factors of the impeller, including the shape of the blade leading edge, blade inlet angle, number and thickness of blades, surface roughness, wrap angle, impeller outlet width, inlet hub diameter, and tip clearance. The pump analyzed in this study, which exhibited issues of vibration and noise in actual industrial settings, was evaluated by varying only the shroud diameter based on Gulich’s theory, while keeping other parameters constant, to assess the effects on cavitation phenomena across five different impellers. Single-phase analysis was initially conducted to evaluate the performance of each pump model, with the reliability of the numerical analysis methods validated by comparison with experimental data. Furthermore, to analyze cavitation phenomena, a multiphase flow analysis was performed using the Rayleigh–Plesset model within a computational fluid dynamics framework. Quantitative analysis of cavitation occurrence, NPSH3% head-drop performance, and bubble volume was conducted. The results confirmed that the M1 model, featuring a shroud diameter of 560 mm, exhibited superior cavitation resistance. Variations in cavitation occurrence observed under three different flow conditions demonstrated a nonlinear trend, but overall, improvements were noted within a specific diameter range. This study offers valuable insights and data for pump design applicable in real-world industrial settings. Full article
(This article belongs to the Section Turbomachinery)
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4 pages, 1016 KiB  
Proceeding Paper
An Innovative Solar Pump Applicable in Water Distribution Networks
by Hana Javadi Nejad, Behrouz Pirouz, Michele Turco, Seyed Navid Naghib, Stefania Anna Palermo and Patrizia Piro
Eng. Proc. 2024, 69(1), 107; https://doi.org/10.3390/engproc2024069107 - 10 Sep 2024
Abstract
The analysis of GHG emissions for different sectors shows that one of the main contributions, responsible for 25%, is electricity and heat production. An important aspect of electricity use concerns motor pumps, which are used for both urban water supply and agricultural water [...] Read more.
The analysis of GHG emissions for different sectors shows that one of the main contributions, responsible for 25%, is electricity and heat production. An important aspect of electricity use concerns motor pumps, which are used for both urban water supply and agricultural water systems. Generally, the highest consumption corresponds to summer, when the maximum solar radiation makes the use of solar water pumps possible. However, the total conversion of energy by conventional solar pumps is about 10% of the solar energy. This low efficiency has limited the choice of solar water pumps to areas without alternative power sources. Moreover, the final efficiency will further decrease due to that of other parts of the system, so, in order to achieve higher efficiency and sustainability, a novel method for solar water pumps must be developed. The new solar pump that we propose will take advantage of the efficiency of solar concentration dishes to absorb solar radiation, which is about 80–90%, will pump water using water vapor pressure, and will not need an electrical motor. It will offer several benefits besides high efficiency in pumping water, like the number of mechanical parts required and their maintenance costs, making its application easy and removing the limitations of typical systems. Full article
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5 pages, 1507 KiB  
Proceeding Paper
Real-Time Burst Localization in Complex Water Transmission Lines Using Hydraulic Gradient Analysis
by Taegon Ko, Raziyeh Farmani, Edward Keedwell and Xi Wan
Eng. Proc. 2024, 69(1), 106; https://doi.org/10.3390/engproc2024069106 - 10 Sep 2024
Abstract
This study introduces a methodology for the real-time detection and localization of bursts in water transmission lines by comparing estimated and measured Hydraulic Gradient (HG) values across pipe segments. Employing a deep learning approach, the method analyzes the complex relationships between system states [...] Read more.
This study introduces a methodology for the real-time detection and localization of bursts in water transmission lines by comparing estimated and measured Hydraulic Gradient (HG) values across pipe segments. Employing a deep learning approach, the method analyzes the complex relationships between system states such as flows, HGs, pump and valve operations. The approach capitalizes on the difference in HG values before and after a burst, enabling precise burst localization. Tested on a real incident, the method proved effective in accurately identifying burst locations, offering a practical solution for operators. Full article
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12 pages, 2763 KiB  
Article
Terahertz Modulation Properties Based on ReS2/Si Heterojunction Films
by Xunjun He, Han Xu, Hongyuan Liu, Jia Nie and Guangjun Lu
Crystals 2024, 14(9), 799; https://doi.org/10.3390/cryst14090799 - 10 Sep 2024
Abstract
Low cost, low power consumption and high performance are urgent needs for the application of terahertz modulation devices in the 6G field. Rhenium disulfide (ReS2) is one of the ideal candidate materials due to its unique direct band gap, but it [...] Read more.
Low cost, low power consumption and high performance are urgent needs for the application of terahertz modulation devices in the 6G field. Rhenium disulfide (ReS2) is one of the ideal candidate materials due to its unique direct band gap, but it lacks in-depth research. In this work, a highly stable ReS2 nanodispersion was prepared by liquid-phase exfoliation, and a uniform, dense and well-crystallized ReS2 film was prepared on high-resistivity silicon by drop casting. The morphological, optical and structural properties of the ReS2/Si heterojunction film were characterized by OM, SEM, AFM, XRD, RS and PL. The terahertz performance was tested by using a homemade THz-TDS instrument, and the influence of different laser wavelengths and powers on the terahertz modulation performance of the sample was analyzed. The modulation depth of the sample was calculated based on the transmission curve, and the changes in the refractive index and conductivity of the sample with frequency at the corresponding laser power were calculated. The results show that the fabricated ReS2/Si heterojunction terahertz modulator can stably achieve 30% broadband modulation in the range of 0.3~1.5 THz under the low-power pumping of 1555 mW/cm2, and the maximum conductivity is 3.8 Ω−1m−1. Full article
(This article belongs to the Special Issue Advanced Research in 2D Materials)
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13 pages, 7416 KiB  
Article
Novel Power-Efficient Fast-Locking Phase-Locked Loop Based on Adaptive Time-to-Digital Converter-Aided Acceleration Compensation Technology
by Ligong Sun, Yixin Luo, Zhiyao Deng, Jinchan Wang and Bo Liu
Electronics 2024, 13(18), 3586; https://doi.org/10.3390/electronics13183586 - 10 Sep 2024
Abstract
This paper proposes an adaptive acceleration lock compensation technology for phase-locked loops (PLLs) based on a novel dual-mode programmable ring voltage-controlled oscillator (ring-VCO). In addition, a time-to-digital converter (TDC) is designed to accurately quantify the phase difference from the phase frequency detector (PFD) [...] Read more.
This paper proposes an adaptive acceleration lock compensation technology for phase-locked loops (PLLs) based on a novel dual-mode programmable ring voltage-controlled oscillator (ring-VCO). In addition, a time-to-digital converter (TDC) is designed to accurately quantify the phase difference from the phase frequency detector (PFD) in order to optimize the dead-zone effect while dynamically switching an auxiliary charge pump (CP) module to realize fast phase locking. Furthermore, a TDC-controlled three/five-stage dual-mode adaptively continuously switched VCO is proposed to optimize the phase noise (PN) and power efficiency, leading to an optimal performance tradeoff of the PLL. Based on the 180 nm/1.8 V standard CMOS technology, the complete PLL design and a corresponding simulation analysis are implemented. The results show that, with a 1 GHz reference signal as the input, the output frequency is 50–324 MHz, with a wide tuning range of 260 MHz and a low phase noise of −98.07 dBc/Hz@1 MHz. The key phase-locking time is reduced to 1.11 μs, and the power dissipation is lowered to 1.86 mW with a layout area of 66 μm × 128 μm. A significantly remarkable multiobjective performance tradeoff with topology optimization is realized, which is in contrast to several similar design cases of PLLs. Full article
(This article belongs to the Section Circuit and Signal Processing)
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22 pages, 1665 KiB  
Article
Design, Building and Deployment of Smart Applications for Anomaly Detection and Failure Prediction in Industrial Use Cases
by Ricardo Dintén and Marta Zorrilla
Information 2024, 15(9), 557; https://doi.org/10.3390/info15090557 - 10 Sep 2024
Abstract
This paper presents a comparative analysis of deep learning techniques for anomaly detection and failure prediction. We explore various deep learning architectures on an IoT dataset, including recurrent neural networks (RNNs, LSTMs and GRUs), convolutional neural networks (CNNs) and transformers, to assess their [...] Read more.
This paper presents a comparative analysis of deep learning techniques for anomaly detection and failure prediction. We explore various deep learning architectures on an IoT dataset, including recurrent neural networks (RNNs, LSTMs and GRUs), convolutional neural networks (CNNs) and transformers, to assess their effectiveness in anomaly detection and failure prediction. It was found that the hybrid transformer-GRU configuration delivers the highest accuracy, albeit at the cost of requiring the longest computational time for training. Furthermore, we employ explainability techniques to elucidate the decision-making processes of these black box models and evaluate their behaviour. By analysing the inner workings of the models, we aim at providing insights into the factors influencing failure predictions. Through comprehensive experimentation and analysis on sensor data collected from a water pump, this study contributes to the understanding of deep learning methodologies for anomaly detection and failure prediction and underscores the importance of model interpretability in critical applications such as prognostics and health management. Additionally, we specify the architecture for deploying these models in a real environment using the RAI4.0 metamodel, meant for designing, configuring and automatically deploying distributed stream-based industrial applications. Our findings will offer valuable guidance for practitioners seeking to deploy deep learning techniques effectively in predictive maintenance systems, facilitating informed decision-making and enhancing reliability and efficiency in industrial operations. Full article
(This article belongs to the Special Issue Advances in Machine Learning and Intelligent Information Systems)
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4 pages, 445 KiB  
Proceeding Paper
TwinOptPRO—Digital Platform for Online Pump Scheduling Optimization
by Thomas Bernard, Jochen W. Deuerlein, Martin Dresen, Michael Fischer, Nicolai Guth, Rüdiger Höche, Christian Kühnert, Christa Mastaller, Gerhard Rappold, Gordon Schlolaut, Andreas Wunsch and Mathias Ziebarth
Eng. Proc. 2024, 69(1), 94; https://doi.org/10.3390/engproc2024069094 - 10 Sep 2024
Abstract
Climate change is leading to a general shortage of raw water availability combined with more pronounced seasonality and dry phases. The goal of the collaborative research project TwinOptPRO is to contribute to EU-wide climate neutrality in 2050 by the minimization of energy supply [...] Read more.
Climate change is leading to a general shortage of raw water availability combined with more pronounced seasonality and dry phases. The goal of the collaborative research project TwinOptPRO is to contribute to EU-wide climate neutrality in 2050 by the minimization of energy supply for water treatment and pumps in drinking water distribution systems. For that purpose, a digital platform that combines different forecasting models with simulation and optimization modules was developed. The aim is to ensure secure and compliant supply to customers in the future while maximizing the use of renewable energy and minimizing costs. Full article
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20 pages, 4209 KiB  
Article
How Not to Reduce Carbon Dioxide Emissions: An Unbalanced Focus on Energy Efficiency in Germany’s Building Rehabilitation Policies
by Ray Galvin
Energies 2024, 17(17), 4524; https://doi.org/10.3390/en17174524 - 9 Sep 2024
Abstract
Germany needs to reduce CO2 emissions from space heating in its old buildings to net zero by 2045 to fulfil its climate goals. However, direct CO2 reduction measures in existing buildings receive relatively little subsidy support from the federal government’s German [...] Read more.
Germany needs to reduce CO2 emissions from space heating in its old buildings to net zero by 2045 to fulfil its climate goals. However, direct CO2 reduction measures in existing buildings receive relatively little subsidy support from the federal government’s German Development Bank, compared to generous subsidies for energy efficiency measures. This interdisciplinary paper evaluates this phenomenon by comparing costs and CO2 abatement effects of ever higher energy efficiency measures, alongside the costs of direct CO2 reduction through heat pumps and onsite photovoltaics. It uses a set of carefully selected reports on the costs and benefits of renovation to a range of energy efficiency standards in three common types of multi-apartment buildings in Germany, updating these for 2024 construction, energy, and finance costs. The cost of the CO2 saved is extremely high with energy efficiency measures and absurdly high with the highest energy efficiency standards, up to 20 times the cost of CO2 abatement through other means, such as offsite renewables. This reduces markedly with onsite CO2 reduction measures. This paper sets this analysis in the context of asking what social, cultural, and discursive factors extol energy efficiency so highly that policy tends to thwart its own stated goal of deeply reducing CO2 emissions. Full article
(This article belongs to the Special Issue Energy Transition and Environmental Sustainability: 3rd Edition)
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15 pages, 2831 KiB  
Article
Experimental Study on the Combined Heat Storage and Supply of Air/Water-Source Heat Pumps
by Qi Zhao, Shijie Gu, Shuang Ma, Bo Tian, Bowen Chu and Hongwen Jin
Buildings 2024, 14(9), 2836; https://doi.org/10.3390/buildings14092836 - 9 Sep 2024
Abstract
As the application of renewable energy becomes increasingly extensive, heat pump technology with renewable energy as the heat source is achieving good results. Air-source heat pumps and water-source heat pumps can be widely used in cold areas. In this work, an integrated combined [...] Read more.
As the application of renewable energy becomes increasingly extensive, heat pump technology with renewable energy as the heat source is achieving good results. Air-source heat pumps and water-source heat pumps can be widely used in cold areas. In this work, an integrated combined storage and supply system of an air-source heat pump and a water-source heat pump was studied, and the heating characteristics of the system at the beginning, middle, and end of the heating period were examined. It was found that, when the outdoor temperature of the system was very low, the efficiency of the combined storage and supply system reached the highest value of 2.57 when the source-side water tank was kept at 30 °C, and the performance of the combined storage and supply system was better than that of the air-source heat pump and the water-source heat pump in cold regions. Meanwhile, the independent storage of the air-source heat pump and the combined storage and supply system can be used for heating at the beginning and end of the heating period. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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16 pages, 5004 KiB  
Article
Research on CdSe/ZnS Quantum Dots-Doped Polymer Fibers and Their Gain Characteristics
by Xuefeng Peng, Zhijian Wu and Yang Ding
Nanomaterials 2024, 14(17), 1463; https://doi.org/10.3390/nano14171463 - 9 Sep 2024
Abstract
Polymer fibers are considered ideal transmission media for all-optical networks, but their high intrinsic loss significantly limits their practical use. Quantum dot-doped polymer fiber amplifiers are emerging as a promising solution to this issue and are becoming a significant focus of research in [...] Read more.
Polymer fibers are considered ideal transmission media for all-optical networks, but their high intrinsic loss significantly limits their practical use. Quantum dot-doped polymer fiber amplifiers are emerging as a promising solution to this issue and are becoming a significant focus of research in both academia and industry. Based on the properties of CdSe/ZnS quantum dots and PMMA material, this study experimentally explores three fabrication methods for CdSe/ZnS quantum dots-doped PMMA fibers: hollow fiber filling, melt-drawing, and melt extrusion. The advantages and disadvantages of each method and key issues in fiber fabrication are analyzed. Utilizing the CdSe/ZnS quantum dots-doped PMMA fibers that were fabricated, we theoretically analyzed the key factors affecting gain performance, including fiber length, quantum dots doping concentration, and signal light intensity. Under the conditions of 1.5 W power and 445 nm laser pumping, a maximum on-off gain of 16.2 dB was experimentally achieved at 635 nm. Additionally, using a white light LED as the signal source, a broadband on-off gain with a bandwidth exceeding 70 nm and a maximum gain of 12.4 dB was observed in the 580–650 nm range. This research will contribute to the development of quantum dots-doped fiber devices and broadband optical communication technology, providing more efficient solutions for future optical communication networks. Full article
(This article belongs to the Special Issue Innovations in Nano-Based Optoelectronic Devices)
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15 pages, 5431 KiB  
Article
Synergistic Effect of Elliptic Textures and H-DLC Coatings for Enhancing the Tribological Performance of CuAl10Fe5Ni5 Valve Plate Surfaces
by Mengjiao Wang, Mingbo Zhu, Xinzheng Hu, Kun Liu, Xuefeng Fan, Xiangkai Meng, Xudong Peng and Jinqing Wang
Coatings 2024, 14(9), 1161; https://doi.org/10.3390/coatings14091161 - 9 Sep 2024
Abstract
Axial piston pumps with compact structures and high efficiency are widely used in construction machinery. The efficiency and lifetime strongly depend on the tribological performance of the pump’s valve plate pair. To enhance the tribological performance of the valve plate pair, surface textures, [...] Read more.
Axial piston pumps with compact structures and high efficiency are widely used in construction machinery. The efficiency and lifetime strongly depend on the tribological performance of the pump’s valve plate pair. To enhance the tribological performance of the valve plate pair, surface textures, and H-DLC coatings were fabricated to modify the CuAl10Fe5Ni5 surfaces. The influences of elliptic textures of different sizes and textured H-DLC coatings on the surface friction and wear properties of the valve plate surface under oil lubrication were evaluated using a ring-on-disk tribometer. The results reveal that the friction and wear properties of the CuAl10Fe5Ni5 surfaces are significantly enhanced by elliptic textures, and the friction coefficient and wear rate of textured CuAl10Fe5Ni5 with E90 are maximally decreased by 95% and 87%, respectively. Compared with the surface textures and H-DLC coatings, the textured H-DLC coating has the greatest ability to reduce wear and adhesion. The wear rate of the textured H-DLC coating is further reduced by 98%. This improvement can be explained by the synergistic effect of the elliptic textures and H-DLC coatings, which are attributed to the reduced contact area, debris capture, and secondary lubrication of the elliptic textures, and increased surface hardness. Full article
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18 pages, 4187 KiB  
Article
Utilizing Connection of Multiple Peltier Cells to Enhance the Coefficient of Performance
by Jan Rimbala, Jan Kyncl, Jan Koller and Ghaeth Fandi
Energies 2024, 17(17), 4509; https://doi.org/10.3390/en17174509 - 9 Sep 2024
Abstract
Peltier cells are commonly used in low-power cooling applications, such as automotive refrigerators and electronics temperature regulation systems. These applications are typically low-energy in nature. There is currently a growing emphasis on energy conservation and waste heat utilization in the energy industry. This [...] Read more.
Peltier cells are commonly used in low-power cooling applications, such as automotive refrigerators and electronics temperature regulation systems. These applications are typically low-energy in nature. There is currently a growing emphasis on energy conservation and waste heat utilization in the energy industry. This paper explores the possibility of improving the heating or cooling coefficient of performance (COP) of Peltier cells through intelligent serial and parallel connections. The purpose of this work is to raise the question of whether it would be possible to reconsider the concept of harnessing the “energy” potential of Peltier cells. The utilized model is in line with the current state of the art, and the case study is based on parameters measured on a commercially available Peltier cell. The resulting COP, when considering current materials, remains inferior to the COP of compressor-based heat pumps. For low-power devices, it can represent a technically and economically comparable solution. Full article
(This article belongs to the Section F: Electrical Engineering)
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16 pages, 4980 KiB  
Communication
Short Communication: Novel Di- and Triselenoesters as Effective Therapeutic Agents Inhibiting Multidrug Resistance Proteins in Breast Cancer Cells
by Dominika Radomska, Robert Czarnomysy, Krzysztof Marciniec, Justyna Nowakowska, Enrique Domínguez-Álvarez and Krzysztof Bielawski
Int. J. Mol. Sci. 2024, 25(17), 9732; https://doi.org/10.3390/ijms25179732 - 8 Sep 2024
Abstract
Breast cancer has the highest incidence rate among all malignancies worldwide. Its high mortality is mainly related to the occurrence of multidrug resistance, which significantly limits therapeutic options. In this regard, there is an urgent need to develop compounds that would overcome this [...] Read more.
Breast cancer has the highest incidence rate among all malignancies worldwide. Its high mortality is mainly related to the occurrence of multidrug resistance, which significantly limits therapeutic options. In this regard, there is an urgent need to develop compounds that would overcome this phenomenon. There are few reports in the literature that selenium compounds can modulate the activity of P-glycoprotein (MDR1). Therefore, we performed in silico studies and evaluated the effects of the novel selenoesters EDAG-1 and EDAG-8 on BCRP, MDR1, and MRP1 resistance proteins in MCF-7 and MDA-MB-231 breast cancer cells. The cytometric analysis showed that the tested compounds (especially EDAG-8) are inhibitors of BCRP, MDR1, and MRP1 efflux pumps (more potent than the reference compounds—novobiocin, verapamil, and MK-571). An in silico study correlates with these results, suggesting that the compound with the lowest binding energy to these transporters (EDAG-8) has a more favorable spatial structure affecting its anticancer activity, making it a promising candidate in the development of a novel anticancer agent for future breast cancer therapy. Full article
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