Search Results (4,863)

Agastache rugosa, a traditional Asian herbal medicine, is primarily used for digestive problems; yet, its cognitive benefits remain unexplored. This study evaluated the anti-amnesic effects of A. rugosa extract (ARE) on scopolamine (SCO)-induced memory impairment in mice. Mice received 100 or 200 mg/kg ARE orally for 5 days, followed by SCO injection. The ARE demonstrated significant antioxidant (DPPH IC₅₀: 75.3 µg/mL) and anti-inflammatory effects (NO reduction). Furthermore, the ARE significantly improved memory performance in the passive avoidance test (escape latency: 157.2 s vs. 536.9 s), the novel object recognition test (novel object preference: 47.6% vs. 66.3%) and the Morris water maze (time spent in the target quadrant: 30.0% vs. 45.1%). The ARE reduced hippocampal acetylcholinesterase activity (1.8-fold vs. 1.1-fold) while increasing choline acetyltransferase (0.4-fold vs. 1.0-fold) and muscarinic acetylcholine receptor subtype I (0.3-fold vs. 1.6-fold) expression. The ARE improved hippocampal neurogenesis via doublecortin- (0.4-fold vs. 1.1-fold) and KI-67-positive (6.3 vs. 12.0) cells. Therefore, the ARE exerts protective effects against cognitive decline through cholinergic system modulation and antioxidant activity, supporting its potential use as a cognitive enhancer. Full article

From the vineyard to the bottle, the winemaking process generates a variety of by-products, such as vinasses, spent filter cakes, grape pomace, grape lees, and vine shoots. To avoid damaging the environment and to reduce economic impacts, the by-products and wastes must be handled, disposed of, or recycled properly. This review focuses on an environmentally friendly approach to the management and added value of winemaking by-products, such as grape pomace or grape marc, by using vermicomposting. Vermicompost is a well-known organic fertilizer with potential uses in soil bioremediation and the conservation of soil health. To achieve environmental neutral agriculture practices, vermicomposting is a promising tool for resilient and sustainable viticulture and winemaking. Vermicomposting is a simple, highly beneficial, and waste-free method of converting organic waste into compost with high agronomic value and a sustainable strategy in line with the principles of the circular economy. Full article

Power scarcity and pollution can be overcome with the use of green energy forms like ethanol, biogas, electricity, hydrogen, etc., especially energy produced from renewable and industrial feedstocks. In hilly areas, pine needles are the most abundant biomass that has a low possibility of valorization due to high lignin content. On the other hand, anaerobic digestion (AD) of lignin and animal waste has low biogas yield due to poor conductivity. This study focuses on the simultaneous production of biogas and electricity through the co-digestion of cow dung and pine needles. The digester was initially established and stabilized in the lab to ensure a continuous supply of inoculum throughout the experiment. The optimization process involved the determination of an ideal cow dung-to-water ratio and selecting the appropriate conductive material that can enhance the energy generation from the feedstock. Afterward, both batch and continuous anaerobic digestion experiments were conducted. The results revealed that the addition of powdered graphite (5 mM), activated charcoal (15 mM), and biochar (25 mM) exhibited maximum voltage of 0.71 ± 0.013 V, 0.56 ± 0.013 V, and 0.49 ± 0.011 V on the 30th, 25th and 20th day of AD, respectively. The batch experiment showed that 5 mM graphite powder enhanced electron transfer in the AD process and generated a voltage of 0.77 ± 0.014 V on the 30th day, indicating an increase of ~1.5-fold as compared to the control (0.56 ± 0.019 V). The results from the continuous AD process showed that the digester with cow dung, pine needle, and a conductive material in combination exhibited the maximum voltage of 0.76 ± 0.012 V on the 21st day of AD, while the digester with cow dung only exhibited a maximum voltage of 0.62 ± 0.015 V on the 22nd day of AD, representing a 1.3-fold increase over the control. Furthermore, the current work used discarded plastic items and electrodes from spent batteries to emphasize waste management and aid in attaining sustainable energy and development goals. Full article

Industrial and domestic human activities have a significant impact on the environment, contributing, among other things, to the increased pollution of natural waters. The spread of heavy metals is particularly dangerous to the health and life of living organisms due to the high accumulation potential of, among others, Cr (VI), Zn (II), Cu (II), Cd (II), Fe (II), and Ni (II). In order to remove, concentrate, and/or recover ions of these metals, various physical and/or chemical methods are commonly used. In this study, spent coffee grounds (SCGs) efficiently removed copper ions from simulated aqueous solutions, especially at low metal ion concentrations. Without additional modification, coffee grounds performed comparably to traditional adsorbents like activated carbon or ion exchangers. It was found that used ground coffee grounds effectively removed Cu (II) ions at a wide range of concentrations, with the highest efficiency (over 85%) obtained for dilute solutions. On the other hand, regeneration tests performed using a 10% hydrochloric acid solution successfully restored the coffee residue adsorbent, achieving a desorption efficiency of about 35%. This method concentrated the solution and facilitated efficient metal recovery by minimizing acid usage. The sorbent used is an innovative, cheap, and easy-to-use material with high sorption capabilities. Full article

The scientific field of precision agriculture employs increasingly innovative techniques to optimize inputs, maximize profitability, and reduce environmental impact. However, obtaining a high number of soil samples is challenging in order to make precision agriculture viable. There is a trade-off between the amount of data needed and the time and resources spent to obtain these data compared to the accuracy of the maps produced with more or fewer points. In the present study, the research was based on an exhaustive dataset of apparent electrical conductivity (aEC) containing 3906 points distributed along 26 transects with spacing between each of up to 40 m, measured by the proximal soil sensor EM38-MK2, for a grain-producing area of 72 ha in São Paulo, Brazil. A second sparse dataset was simulated, showing only four transects with a 400 m distance and, in the end, only 162 aEC points. The aEC map via ordinary kriging (OK) from the grid with 26 transects was considered the reference, and two other mapping approaches were used to map aEC via sparse grid: kriging with external drift (KED) and geographically weighted regression (GWR). These last two methods allow the increment of auxiliary variables, such as those obtained by remote sensors that present spatial resolution compatible with the pivot scale, such as data from the Landsat-8, Aster, and Sentinel-2 satellites, as well as ten terrain covariates derived from the Alos Palsar digital elevation model. The KED method, when used with the sparse dataset, showed a relatively good fit to the aEC data (R² = 0.78), with moderate prediction accuracy (MAE = 1.26, RMSE = 1.62) and reasonable predictability (RPD = 1.76), outperforming the GWR method, which had the weakest performance (R² = 0.57, MAE = 1.78, RMSE = 2.30, RPD = 0.81). The reference aEC map using the exhaustive dataset and OK showed the highest accuracy with an R² of 0.97, no systematic bias (ME = 0), and excellent precision (RMSE = 0.56, RPD = 5.86). Management zones (MZs) derived from these maps were validated using soil texture data from clay samples measured at 0–10 cm depth in a grid of 72 points. The KED method demonstrated the highest potential for accurately defining MZs for irrigation, producing a map that closely resembled the reference MZ map, thereby providing reliable guidance for irrigation management. Full article

This study addresses the impact of urban parks on the self-rated health of office workers under 40, a demographic experiencing significant increases in depressive symptoms during the pandemic. This study in Baise City, China, aims to fill this gap by exploring the relationships between landscape quality, leisure time spent in parks, place attachment, and self-rated health among 411 office workers aged 18 to 40. Structural equation modeling was used to assess these relationships, and multigroup analysis (MGA) in SmartPLS evaluated differences between subgroups. The findings reveal a strong link between urban park landscape quality and leisure time spent in parks, place attachment, and self-rated health. Although the old-fashioned park showed lower overall performance in the study variables compared to the modern park, it had a stronger relationship between landscape quality and place attachment. Leisure time spent in parks did not directly impact self-rated health but was mediated by place attachment. MGA results indicated that while leisure time in parks positively affected self-rated health for single participants, it had a negative effect for married participants. These results underscore the importance of tailoring urban park design and management to accommodate the varying needs of different demographics. This research provides new insights into enhancing office workers’ self-rated health through environmental design and supports the objectives of the Healthy China strategy and Sustainable Development Goal 11. Full article

This study focuses on applying ash reduction treatments in order to explore the potential for industrial-scale thermochemical utilization of Spent Mushroom Compost (SMC). SMC is a waste byproduct generated by the mushroom industry. Typically, for every kilogram of produced mushrooms, five kilograms of SMC are discarded, with current disposal methods involving landfills or incineration, causing environmental problems. Utilizing SMC effectively presents challenges due to the inherent properties of this biomass type, characterized by high moisture and ash content, low fixed carbon content, and material heterogeneity. These attributes create difficulties when employing a thermochemical valorization route due to the low carbon content and mineral treatments involved. The results have unveiled the heterogeneous nature of the material and its individual components when physically separated. Among the three identified fractions (agglomerated, woody, and fines), the woody fraction showed the highest potential for thermochemical utilization. Notably, when subjected to washing with distilled water and citric acid treatments, it resulted in up to 66% ash reduction, a significant outcome. Other fractions of the material may find potential applications in agriculture. The effective utilization of such high-volume waste biomasses demands diverse and innovative approaches, underlining the urgency and complexity of the problem and the need to employ the principles of a circular economy. Full article

(1) Background: This study aimed to investigate whether yoga practice and physical activity level play an essential role in trait mindfulness and perceived stress reduction. Moreover, the study examined the differences in trait mindfulness and perceived stress between women who practiced yoga and those who engaged in other physical activities or were physically inactive, taking into account the time spent on physical activity in accordance with the World Health Organization recommendations. (2) Methods: A sample of 201 women participated in a cross-sectional online-based study, including 96 yoga practitioners and 105 non-practitioners of yoga (including physically active and inactive individuals). The average age of the participants was 36 years (range, 18–72 years; M = 36.19, SD = 11.64). Respondents completed the Mindful Attention Awareness Scale (MAAS) and the Perceived Stress Scale (PSS-10). (3) Results: Women who practiced yoga and were physically active had a significantly higher level of trait mindfulness and lower perceived stress levels than women who did not practice yoga and were physically inactive. An indirect effect of physical activity on perceived stress through mindfulness was shown only for women practicing yoga for at least 150 min per week. (4) Conclusions: This study revealed the importance of frequent yoga practice in reducing perceived stress and improving mindfulness traits. These findings may serve as a basis for implementing preventive actions in women experiencing high levels of everyday stress. Full article

No Money No Time (NMNT) is a culinary nutrition website designed to optimize diet quality. The primary aim was to evaluate the impact of an online targeted nutrition challenge email campaign that encouraged engagement with NMNT and goal setting to improve diet quality and weekly food expenditure. A secondary aim was to assess NMNT engagement. Australian adults ≥18 years were recruited to the eHealth nutrition challenge delivered via weekly emails. Diet quality was assessed using the Healthy Eating Quiz (HEQ) diet quality tool. Engagement was assessed using email open and click-through rates. Intention-to-treat (ITT) analysis was conducted using mixed effects linear regression. Of 481 adults (49.7 ± 13.9 years, 84% female) who enrolled 79 (16%) completed the challenge. ITT results indicated statistically significant 6-week increases in diet quality score (+3.8 points p ≤ 0.001, d = 0.58) with sub-scale improvements in vegetables (+0.9 points, p = 0.01, d = 0.32), fruit (+1.2 points, p ≤ 0.001, d = 0.55), and dairy (+0.9 points, p ≤ 0.001, d = 0.58). There were significant post-challenge reductions in household spending on takeaway/snacks/coffee of AUD 8.9 per week (p = 0.01, d = 0.29), body weight reduction (−0.6 kg, p = 0.03, d = 0.26), and BMI (−0.2 kg/m²p = 0.02, d = 0.28). The email open rate remained constant at around 67% (56% to 75%), with an average click-through rate of 18% (7.1% to 37.9%). The eHealth nutrition challenge significantly improved diet quality while reducing BMI and money spent on discretionary foods. Strategies to scale the challenge should be tested as an innovative population strategy for improving diet quality, health indicators, and managing household food budgets. Full article

Rainwater and sewage are important pollution sources for surface water bodies. Vertical greening systems (VGSs) are extensively employed for these wastewater treatments due to the green and sustainable characteristics, as well as their high-efficiency in pollutant (organic matter, nitrogen, and phosphorus) removal. At present, more and more VGSs are designed with green buildings, serving city ecosystems. This study provides an overview of different kinds of VGSs for rain and sewage treatment, emphasizing their types, design, mechanisms, selection of plants, and growth substrate. Plants play a crucial role in pollutant removal, and different plants usually obtain different efficiencies of water treatment. Climbing plants and ornamental plants with fast growth rates are priority selections for VGSs, including Canna lilies, Jasmine, Grape vine, Boston ivy, Pittosporum tobira, Pelargonium australe, Mentha aquatica, and Lythrum salicaria. The substrate is the most critical part of the VGS, which plays an important role in regulating water flow, supporting plant growth, promoting biofilm growth, filtering pollutants, and adsorbing nutrients. The single substrate either has a blockage problem or has a short holding time. Therefore, a number of studies have mixed the substrates and integrated the advantages of the substrates to form a complementary effect, thereby improving the overall purification efficiency and stability. Novel substrates (sand, spent coffee grounds, date seeds, coffee grinds, reed-based, etc.) are usually mixed with coco coir, light-weight expanded clay, growstone, or perlite at a certain ratio to obtain optimum treatment performance. Moreover, plants in clay show more significant growth advantages and health statuses than in zeolite or soil. Operating parameters are also significant influences on the treatment performance. This review provides theoretical and technical support for designing sustainable, environmentally friendly, and cost-effective VGSs in treating rainwater and sewage. Full article

Electroconvulsive therapy (ECT) is an effective treatment for severe and drug-resistant depression, yet its mode of action remains poorly understood. This study aimed to evaluate the effects of ECT on neurometabolism using ex vivo ¹H-[¹³C]-NMR spectroscopy in conjunction with intravenous infusion of [1,6-¹³C₂]glucose in a chronic variable mild stress (CVMS) model of depression. Both CVMS and control mice were subjected to seven sessions of electroconvulsive shock under mild isoflurane anesthesia. The CVMS mice exhibited a reduction in sucrose preference (CVMS 67.1 ± 14.9%, n = 5; CON 86.5 ± 0.6%, n = 5; p = 0.007), and an increase in immobility duration (175.9 ± 22.6 vs. 92.0 ± 23.0 s, p < 0.001) in the forced-swim test. The cerebral metabolic rates of glucose oxidation in glutamatergic (CMR_Glc(Glu)) (CVMS 0.134 ± 0.015 µmol/g/min, n = 5; CON 0.201 ± 0.045 µmol/g/min, n = 5; p_adj = 0.04) and GABAergic neurons (CMR_Glc(GABA)) (0.030 ± 0.002 vs. 0.046 ± 0.011 µmol/g/min, p_adj = 0.04) were reduced in the prefrontal cortex (PFC) of CVMS mice. ECT treatment in CVMS mice normalized sucrose preference [F(1,27) = 0.0024, p = 0.961] and immobility duration [F(1,28) = 0.434, p = 0.515], but not the time spent in the center zone (CVMS + ECT 10.4 ± 5.5 s, CON + sham 22.3 ± 11.4 s, p_adj = 0.0006) in the open field test. The ECT-treated CVMS mice exhibited reduced (p_adj = 0.021) CMR_Glc(Glu) in PFC (0.169 ± 0.026 µmol/g/min, n = 8) when compared with CVMS mice, which underwent the sham procedure (0.226 ± 0.030 µmol/g/min, n = 8). These observations are consistent with ECT’s anticonvulsant hypothesis for its anti-depressive action. Full article

Spent mushroom substrates (SMSs) and mushroom basal bodies (MBBs) are significant by-products because of their nutrient content even after harvesting. This study aimed to evaluate the effect of these two by-products, derived from Agaricus bisporus (Ab) and Cyclocybe cylindracea (Cc) cultivation, as potential growth and biochemical composition add-value enhancers of edible mushroom mycelia such as Pleurotus ostreatus, C. cylindracea, and Lentinula edodes. Fungal growth substrates enriched with SMS and MBB extracts significantly affected the growth of mushroom mycelia. In particular, on P. ostreatus, the MBBs Ab and Cc extracts determined an increase in mycelial weight by 89.5%. Also, by-products influenced mushrooms’ mycelial texture, which appeared more floccose and abundant in growth. FT-IR analysis showed that L. edodes mycelium, grown on MBB substrates, showed the highest increase in bands associated with proteins and chitin. Results demonstrated that mushroom by-products enhance mycelial growth and confer an enrichment of compounds that could increase mycelial resistance to pathogens and make a nutraceutical improvement. Full article

Agricultural activities produce large quantities of organic byproducts and waste rich in lignocellulosic materials, which are not sufficiently utilized. In this study, alternative agricultural waste products, namely, spent mushroom substrate (SMS) from the cultivation of edible Pleurotus ostreatus mushrooms and the roots of leafy vegetables from hydroponic cultivation (HRL), were evaluated for their potential to be used as substrates for the cultivation of Pleurotus citrinopileatus and their effects on the quality, the nutritional value, the chemical properties (lipid, protein, carbohydrate, ash, fatty acid and carbohydrate composition) and the bioactive content (total phenolic compounds and antioxidant activity) of produced mushrooms. SMS and HRL (in different ratios with and without additives) and wheat straw with additives (WS—control) were used. During incubation, the linear growth rate of the mycelium (Kr, mm/day) was measured and used for screening. Mushroom cultivation took place in bags, where several characteristics were examined: earliness (duration between the day of substrate inoculation and the day of first harvest) and biological efficiency (B.E. %, the ratio of the weight of fresh mushrooms produced per dry weight of the substrate × 100). Furthermore, this study aimed to investigate the effect of the protein extract (PE) and carbohydrate extract (CE) of P. citrinopileatus after in vitro digestion (fraction less than 3kDa: PE-DP-3; digestate fraction: CE-D, respectively) on the expression of antioxidant-related genes in the THP-1 cell line. The results showed that mushrooms grown on SMS 50%-HRL 40% had the fastest growth (6.1 mm/d) and the highest protein and lipid contents (34.7% d.w.; 5.1% d.w.). The highest B.E. (73.5%), total carbohydrate (65.7%) and total phenolic compound (60.2 mg GAE/g d.w.) values were recorded on the control substrate. Antioxidant activity was observed in all extracts; the total flavonoid content was low in the samples, and the maximum total triterpene value was detected in SMS 80%-HRL 20% (9.8 mg UA/g d.w.). In all mushrooms, linoleic acid (C18:2) was the main fatty acid (above 60%), and fructose was the dominant individual saccharide. In the investigation of the regulation pathway, NFE2L2 gene expression was upregulated only in the SMS 60%-HRL 40% intervention during incubation with CE-D samples. Additionally, the transcription levels of antioxidant-related genes, SOD1, CAT, HMOX1 and GSR, were increased in the SMS 60–30% intervention. Compared to WS, the alternative substrates are observed to trigger a pathway concerning CE that may resist oxidative stress. This study supports the utilization of agricultural byproducts through sustainable and environmentally friendly practices while simultaneously producing high-value-added products such as mushrooms. Therefore, alternative substrates, particularly those containing HRL, could serve as natural sources of antioxidant potential. Full article

Background/Objectives: Most studies have linked mandatory homeschooling during COVID-19 to mental health harm in parents and children, while a minority have found non-significant or beneficial effects. Past studies have not measured mandatory homeschooling continuously over an extended period; consequently, they could not capture compounding mental health effects, which may explain conflicting results. We asked whether children’s cumulative time spent homeschooled during COVID-19 school closure mandates caused compounding harm for parent and child mental health, and whether parent employment, child internet access and educational support from schools (live and pre-recorded online classes, home learning packs) impacted this relationship. We aimed to identify the families at greatest risk of mental health harm during mandatory homeschooling and the educational support that may have mitigated this risk. Methods: Couples completed retrospective, cross-sectional survey questionnaires assessing parent depression, anxiety and stress, child internalizing and externalizing symptoms, and the family’s homeschooling experience. Data were analyzed using mediation analysis total effects, ordinary least squares regression and simple slopes analysis. Results: Both parents and children experienced compounding mental health harm during mandatory homeschooling. Live online classes protected parents and children, while home learning packs protected children. Unexpectedly, reliable internet access and the employment of both parents placed children at greater risk. Conclusions: Findings suggest that long-term mandatory homeschooling during COVID-19 placed families at greater risk of mental health harm. To protect family mental health during homeschooling mandates, schools should provide children with evidence-based educational support. Full article

The rapid development of new energy vehicles and Lithium-Ion Batteries (LIBs) has significantly mitigated urban air pollution. However, the disposal of spent LIBs presents a considerable threat to the environment. Recycling these waste LIBs not only addresses the environmental issues but also compensates for resource shortages and generates substantial economic benefits. Current recycling processes primarily focus on the extraction of valuable metals, often overlooking the treatment of residual waste post-extraction. This project targets the iron phosphate (FePO₄) derived from waste lithium iron phosphate (LFP) battery materials, proposing a direct acid leaching purification process to obtain high-purity iron phosphate. This purified iron phosphate can then be used for the preparation of new LFP battery materials, aiming to establish a complete regeneration cycle that recovers lithium carbonate and iron phosphate from waste LFP materials for the production of LFP. The study investigates process parameters such as acid types and concentrations, leaching time, and the number of leaching cycles. The results demonstrate that, after purification, the levels of impurity metals decrease while the iron content increases correspondingly. Under optimized experimental conditions, the dilute sulfuric acid leaching rates of Al, Cu, Ca, and Ni reached 36.0%, 51.4%, 89.5%, and 90.9%, respectively. Furthermore, hydrothermal treatment in dilute phosphoric acid achieved leaching rates of 87.9%, 85.8%, 98.4%, and 99.1% for Al, Ca, Cu, and Ni, respectively. The microstructure characterization revealed significant changes in phase and grain morphology during the leaching process in dilute phosphoric acid, which are likely associated with the liberation of impurity atoms from the lattice. These findings indicate that acid leaching is highly effective in removing impurities from the iron phosphate recycled from waste LIBs. Full article