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Keywords = stereodynamic chirality probe

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15 pages, 4291 KiB  
Article
“Double-Twist”-Based Dynamic Induction of Optical Activity in Multichromophoric System
by Tomasz Mądry, Agnieszka Czapik and Marcin Kwit
Symmetry 2021, 13(2), 325; https://doi.org/10.3390/sym13020325 - 16 Feb 2021
Cited by 2 | Viewed by 2090
Abstract
The electronic circular dichroism (CD)-silent 2,5-bis(biphen-2-yl)terephthalaldehyde has been used as a sensor (reporter) of chirality for primary amines. The through-space inductor–reporter interactions force a change in the chromophore conformation toward one of the diastereomeric forms. The structure of the reporter, with the terminal [...] Read more.
The electronic circular dichroism (CD)-silent 2,5-bis(biphen-2-yl)terephthalaldehyde has been used as a sensor (reporter) of chirality for primary amines. The through-space inductor–reporter interactions force a change in the chromophore conformation toward one of the diastereomeric forms. The structure of the reporter, with the terminal flipping biphenyl groups, led to generating Cotton effects in both lower- and higher-energy regions of the ECD spectrum. The induction of an optical activity in the chromophore was due to the cascade point-to-axial chirality transmission mechanism. The reporter system turned out to be sensitive to the subtle differences in the inductor structure. Despite the size of the chiral substituent, the molecular structure of the inductor–reporter systems in the solid-state showed many similarities. The most important one was the tendency of the core part of the molecules to adapt pseudocentrosymmetric conformation. Supported by a weak dispersion and Van der Waals interactions, the face-to-face and edge-to-face interactions between the π-electron systems present in the molecule were found to be responsible for the molecular arrangement in the crystal. Full article
(This article belongs to the Special Issue Chiral Auxiliaries and Chirogenesis II)
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