The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates

Everett Clinton Smith

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006254

Rotavirus genome replication: Some assembly required

Courtney P. Long, Sarah M. McDonald

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006242

Elucidating the structure of an infectious protein

Markus Zweckstetter, Jesús R. Requena, Holger Wille

PLOS Pathogens: published April 13, 2017 | https://doi.org/10.1371/journal.ppat.1006229

The role of integration in oncogenic progression of HPV-associated cancers

Alison A. McBride, Alix Warburton

PLOS Pathogens: published April 6, 2017 | https://doi.org/10.1371/journal.ppat.1006211

Regulation of proteinaceous effector expression in phytopathogenic fungi

Kar-Chun Tan, Richard P. Oliver

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006241

The importance of model systems: Why we study a virus on the brink of global eradication

Julie K. Pfeiffer

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006330

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection

Branka Popovic, Mijo Golemac, Jürgen Podlech, Jelena Zeleznjak, Lidija Bilic-Zulle, Miodrag L. Lukic, Luka Cicin-Sain, Matthias J. Reddehase, Tim Sparwasser, Astrid Krmpotic, Stipan Jonjic

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006345

Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

Hadar Israeli, Hadas Cohen-Dvashi, Anastasiya Shulman, Amir Shimon, Ron Diskin

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006337

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

Flora Reverchon, Stéphane Mortaud, Maëliss Sivoyon, Isabelle Maillet, Anthony Laugeray, Jennifer Palomo, Céline Montécot, Améziane Herzine, Sandra Meme, William Meme, François Erard, Bernhard Ryffel, Arnaud Menuet, Valérie F. J. Quesniaux

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006322

Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and packaging occur concurrently at the periphery of the replication center

Gabriela N. Condezo, Carmen San Martín

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006320

A commensal streptococcus hijacks a Pseudomonas aeruginosa exopolysaccharide to promote biofilm formation

Jessica A. Scoffield, Dingyu Duan, Fan Zhu, Hui Wu

PLOS Pathogens: published April 27, 2017 | https://doi.org/10.1371/journal.ppat.1006300

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

Giuseppe Mariggiò, Sandra Koch, Guigen Zhang, Magdalena Weidner-Glunde, Jessica Rückert, Semra Kati, Susann Santag, Thomas F. Schulz

PLOS Pathogens: published April 21, 2017 | https://doi.org/10.1371/journal.ppat.1006335

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division

Kannan Venugopal, Elisabeth Werkmeister, Nicolas Barois, Jean-Michel Saliou, Anais Poncet, Ludovic Huot, Fabien Sindikubwabo, Mohamed Ali Hakimi, Gordon Langsley, Frank Lafont, Sabrina Marion

PLOS Pathogens: published April 21, 2017 | https://doi.org/10.1371/journal.ppat.1006331

A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells

Ciaran E. Finn, Audrey Chong, Kendal G. Cooper, Tregei Starr, Olivia Steele-Mortimer

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006354

Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells

Gergès Rizkallah, Sandrine Alais, Nicolas Futsch, Yuetsu Tanaka, Chloé Journo, Renaud Mahieux, Hélène Dutartre

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006353

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The role of microsporidian polar tube protein 4 (PTP4) in host cell infection

Bing Han, Valérie Polonais, Tatsuki Sugi, Rama Yakubu, Peter M. Takvorian, Ann Cali, Keith Maier, Mengxian Long, Matthew Levy, Herbert B. Tanowitz, Guoqing Pan, Frédéric Delbac, Zeyang Zhou, Louis M. Weiss

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006341

Gre factors-mediated control of hilD transcription is essential for the invasion of epithelial cells by Salmonella enterica serovar Typhimurium

Tania Gaviria-Cantin, Youssef El Mouali, Soazig Le Guyon, Ute Römling, Carlos Balsalobre

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006312

Activated entomopathogenic nematode infective juveniles release lethal venom proteins

Dihong Lu, Marissa Macchietto, Dennis Chang, Mirayana M. Barros, James Baldwin, Ali Mortazavi, Adler R. Dillman

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006302

Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation

Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Christina M. Lalama, Joshua C. Cyktor, Bernard J. Macatangay, Charles R. Rinaldo, Sharon A. Riddler, Evelyn Hogg, Catherine Godfrey, Ann C. Collier, Joseph J. Eron, John W. Mellors, ACTG A5321 Team

PLOS Pathogens: published April 20, 2017 | https://doi.org/10.1371/journal.ppat.1006285

Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins

Biljana Petrovic, Tatiana Gianni, Valentina Gatta, Gabriella Campadelli-Fiume

PLOS Pathogens: published April 19, 2017 | https://doi.org/10.1371/journal.ppat.1006352

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

Sarah R. Beattie, Kenneth M. K. Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K. Caffrey-Carr, Chao Cheng, Candice C. Black, Paul Bowyer, Michael J. Bromley, Joshua J. Obar, Gustavo H. Goldman, Robert A. Cramer

PLOS Pathogens: published April 19, 2017 | https://doi.org/10.1371/journal.ppat.1006340

Skin-resident CD4⁺ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes

Nelson D. Glennie, Susan W. Volk, Phillip Scott

PLOS Pathogens: published April 18, 2017 | https://doi.org/10.1371/journal.ppat.1006349

Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner

Elena Cardenal-Muñoz, Sonia Arafah, Ana Teresa López-Jiménez, Sébastien Kicka, Alexandra Falaise, Frauke Bach, Olivier Schaad, Jason S. King, Monica Hagedorn, Thierry Soldati

PLOS Pathogens: published April 17, 2017 | https://doi.org/10.1371/journal.ppat.1006344

The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus

Jinlin Li, Simone Callegari, Maria G. Masucci

PLOS Pathogens: published April 17, 2017 | https://doi.org/10.1371/journal.ppat.1006338

GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome

Ying Nie, Yong Ran, Hong-Yan Zhang, Zhe-Fu Huang, Zhao-Yi Pan, Su-Yun Wang, Yan-Yi Wang

PLOS Pathogens: published April 17, 2017 | https://doi.org/10.1371/journal.ppat.1006328

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

Jeffrey Downey, Erwan Pernet, François Coulombe, Benoit Allard, Isabelle Meunier, Joanna Jaworska, Salman Qureshi, Donald C. Vinh, James G. Martin, Philippe Joubert, Maziar Divangahi

PLOS Pathogens: published April 14, 2017 | https://doi.org/10.1371/journal.ppat.1006326

TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection

Saumya Maru, Ge Jin, Todd D. Schell, Aron E. Lukacher

PLOS Pathogens: published April 14, 2017 | https://doi.org/10.1371/journal.ppat.1006318

Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

Sarah A. Tursi, Ernest Y. Lee, Nicole J. Medeiros, Michael H. Lee, Lauren K. Nicastro, Bettina Buttaro, Stefania Gallucci, Ronald Paul Wilson, Gerard C. L. Wong, Çagla Tükel

PLOS Pathogens: published April 14, 2017 | https://doi.org/10.1371/journal.ppat.1006315

Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Jessica Rose, Vincent C. Emery, Deepali Kumar, Anders Asberg, Anders Hartmann, Alan G. Jardine, Angelo A. Bignamini, Atul Humar, Avidan U. Neumann

PLOS Pathogens: published April 13, 2017 | https://doi.org/10.1371/journal.ppat.1006299

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Arabidopsis leucine-rich repeat receptor–like kinase NILR1 is required for induction of innate immunity to parasitic nematodes

Badou Mendy, Mary Wanjiku Wang’ombe, Zoran S. Radakovic, Julia Holbein, Muhammad Ilyas, Divykriti Chopra, Nick Holton, Cyril Zipfel, Florian M. W. Grundler, Shahid Siddique

PLOS Pathogens: published April 13, 2017 | https://doi.org/10.1371/journal.ppat.1006284

Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation

Liang-Chun Wang, Qian Yu, Vonetta Edwards, Brian Lin, Jessica Qiu, Jerrold R. Turner, Daniel C. Stein, Wenxia Song

PLOS Pathogens: published April 13, 2017 | https://doi.org/10.1371/journal.ppat.1006269

A novel Meloidogyne graminicola effector, MgGPP, is secreted into host cells and undergoes glycosylation in concert with proteolysis to suppress plant defenses and promote parasitism

Jiansong Chen, Borong Lin, Qiuling Huang, Lili Hu, Kan Zhuo, Jinling Liao

PLOS Pathogens: published April 12, 2017 | https://doi.org/10.1371/journal.ppat.1006301

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry

Yiquan Wu, Adrian Prager, Simone Boos, Moritz Resch, Ilija Brizic, Michael Mach, Sabrina Wildner, Laura Scrivano, Barbara Adler

PLOS Pathogens: published April 12, 2017 | https://doi.org/10.1371/journal.ppat.1006281

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A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells

Cora Stegmann, Daniel Hochdorfer, Diana Lieber, Narmadha Subramanian, Dagmar Stöhr, Kerstin Laib Sampaio, Christian Sinzger

PLOS Pathogens: published April 12, 2017 | https://doi.org/10.1371/journal.ppat.1006273

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Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Yuanjie Liu, Hui Nie, Richeng Mao, Bidisha Mitra, Dawei Cai, Ran Yan, Ju-Tao Guo, Timothy M. Block, Nadir Mechti, Haitao Guo

PLOS Pathogens: published April 11, 2017 | https://doi.org/10.1371/journal.ppat.1006296

Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia

Ushasree Sunkavalli, Carmen Aguilar, Ricardo Jorge Silva, Malvika Sharan, Ana Rita Cruz, Caroline Tawk, Claire Maudet, Miguel Mano, Ana Eulalio

PLOS Pathogens: published April 10, 2017 | https://doi.org/10.1371/journal.ppat.1006327

A quorum sensing-independent path to stumpy development in Trypanosoma brucei

Henriette Zimmermann, Ines Subota, Christopher Batram, Susanne Kramer, Christian J. Janzen, Nicola G. Jones, Markus Engstler

PLOS Pathogens: published April 10, 2017 | https://doi.org/10.1371/journal.ppat.1006324

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation

Xuewu Zhang, Chengliang Zhu, Tianci Wang, Hui Jiang, Yahui Ren, Qi Zhang, Kailang Wu, Fang Liu, Yingle Liu, Jianguo Wu

PLOS Pathogens: published April 10, 2017 | https://doi.org/10.1371/journal.ppat.1006321

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CD8⁺ T cell evasion mandates CD4⁺ T cell control of chronic gamma-herpesvirus infection

Cindy S. E. Tan, Clara Lawler, Philip G. Stevenson

PLOS Pathogens: published April 10, 2017 | https://doi.org/10.1371/journal.ppat.1006311

The Barley stripe mosaic virus γb protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes

Kun Zhang, Yongliang Zhang, Meng Yang, Songyu Liu, Zhenggang Li, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li

PLOS Pathogens: published April 7, 2017 | https://doi.org/10.1371/journal.ppat.1006319

A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry

Mary Jane Drake, Benjamin Brennan, Kenneth Briley Jr, Stephen M. Bart, Eric Sherman, Agnieszka M. Szemiel, Madeleine Minutillo, Frederic D. Bushman, Paul Bates

PLOS Pathogens: published April 7, 2017 | https://doi.org/10.1371/journal.ppat.1006316

A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei

Priscila Peña-Diaz, Marie Vancová, Christian Resl, Mark C. Field, Julius Lukeš

PLOS Pathogens: published April 7, 2017 | https://doi.org/10.1371/journal.ppat.1006310

Neutrophils and Ly6C^hi monocytes collaborate in generating an optimal cytokine response that protects against pulmonary Legionella pneumophila infection

Cierra N. Casson, Jessica L. Doerner, Alan M. Copenhaver, Jasmine Ramirez, Alicia M. Holmgren, Mark A. Boyer, Ingharan J. Siddarthan, Sara H. Rouhanifard, Arjun Raj, Sunny Shin

PLOS Pathogens: published April 6, 2017 | https://doi.org/10.1371/journal.ppat.1006309

DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target

Rubén Soto-Acosta, Patricia Bautista-Carbajal, Margot Cervantes-Salazar, Antonio H. Angel-Ambrocio, Rosa M. del Angel

PLOS Pathogens: published April 6, 2017 | https://doi.org/10.1371/journal.ppat.1006257

Host cell-derived lactate functions as an effector molecule in Neisseria meningitidis microcolony dispersal

Sara Sigurlásdóttir, Jakob Engman, Olaspers Sara Eriksson, Sunil D. Saroj, Nadezda Zguna, Pilar Lloris-Garcerá, Leopold L. Ilag, Ann-Beth Jonsson

PLOS Pathogens: published April 6, 2017 | https://doi.org/10.1371/journal.ppat.1006251

miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis

Carrie M. Rosenberger, Rebecca L. Podyminogin, Alan H. Diercks, Piper M. Treuting, Jacques J. Peschon, David Rodriguez, Madhumati Gundapuneni, Mitchell J. Weiss, Alan Aderem

PLOS Pathogens: published April 5, 2017 | https://doi.org/10.1371/journal.ppat.1006305

An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes

Canrong Zhong, Mengyang Xu, Yan Wang, Jun Xu, Yan Yuan

PLOS Pathogens: published April 5, 2017 | https://doi.org/10.1371/journal.ppat.1006289

Fatty acid DSF binds and allosterically activates histidine kinase RpfC of phytopathogenic bacterium Xanthomonas campestris pv. campestris to regulate quorum-sensing and virulence

Zhen Cai, Zhi-Hui Yuan, Huan Zhang, Yue Pan, Yao Wu, Xiu-Qi Tian, Fang-Fang Wang, Li Wang, Wei Qian

PLOS Pathogens: published April 3, 2017 | https://doi.org/10.1371/journal.ppat.1006304