The microbiome in hematopoietic stem cell transplant recipients and cancer patients: Opportunities for clinical advances that reduce infection

Andrew Y. Koh

PLOS Pathogens: published June 29, 2017 | https://doi.org/10.1371/journal.ppat.1006342

Signaling C-type lectin receptors in antimycobacterial immunity

Mohlopheni J. Marakalala, Hlumani Ndlovu

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006333

Fungal manipulation of hormone-regulated plant defense

Rajesh N. Patkar, Naweed I. Naqvi

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006334

T6SS: The bacterial "fight club" in the host gut

Thibault G. Sana, Kyler A. Lugo, Denise M. Monack

PLOS Pathogens: published June 8, 2017 | https://doi.org/10.1371/journal.ppat.1006325

Bacterial outer membrane vesicles at the plant–pathogen interface

Leron Katsir, Ofir Bahar

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006306

Oxidative stress induced in E. coli by the human antimicrobial peptide LL-37

Heejun Choi, Zhilin Yang, James C. Weisshaar

PLOS Pathogens: published June 30, 2017 | https://doi.org/10.1371/journal.ppat.1006481

Divergent roles for Ly6C⁺CCR2⁺CX3CR1⁺ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major

Audrey Romano, Matheus B. H. Carneiro, Nicole A. Doria, Eric H. Roma, Flavia L. Ribeiro-Gomes, Ehud Inbar, Sang Hun Lee, Jonatan Mendez, Andrea Paun, David L. Sacks, Nathan C. Peters

PLOS Pathogens: published June 30, 2017 | https://doi.org/10.1371/journal.ppat.1006479

Prions amplify through degradation of the VPS10P sorting receptor sortilin

Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer, Suehiro Sakaguchi

PLOS Pathogens: published June 30, 2017 | https://doi.org/10.1371/journal.ppat.1006470

Innate immunity restricts Citrobacter rodentium A/E pathogenesis initiation to an early window of opportunity

Stefanie Buschor, Miguelangel Cuenca, Stephanie S. Uster, Olivier P. Schären, Maria L. Balmer, Miguel A. Terrazos, Christian M. Schürch, Siegfried Hapfelmeier

PLOS Pathogens: published June 29, 2017 | https://doi.org/10.1371/journal.ppat.1006476

Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants

Kevin J. Sokoloski, Lauren M. Nease, Nicholas A. May, Natasha N. Gebhart, Claire E. Jones, Thomas E. Morrison, Richard W. Hardy

PLOS Pathogens: published June 29, 2017 | https://doi.org/10.1371/journal.ppat.1006473

Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor

María Victoria Humbert, Amaka Marian Awanye, Lu-Yun Lian, Jeremy P. Derrick, Myron Christodoulides

PLOS Pathogens: published June 29, 2017 | https://doi.org/10.1371/journal.ppat.1006448

Genomic fossils reveal adaptation of non-autonomous pararetroviruses driven by concerted evolution of noncoding regulatory sequences

Sunlu Chen, Huizhen Zheng, Yuji Kishima

PLOS Pathogens: published June 29, 2017 | https://doi.org/10.1371/journal.ppat.1006413

Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells

Diane L. Bolton, Kathleen McGinnis, Greg Finak, Pratip Chattopadhyay, Raphael Gottardo, Mario Roederer

PLOS Pathogens: published June 27, 2017 | https://doi.org/10.1371/journal.ppat.1006445

Crystal structure of Middle East respiratory syndrome coronavirus helicase

Wei Hao, Justyna Aleksandra Wojdyla, Rong Zhao, Ruiyun Han, Rajat Das, Ivan Zlatev, Muthiah Manoharan, Meitian Wang, Sheng Cui

PLOS Pathogens: published June 26, 2017 | https://doi.org/10.1371/journal.ppat.1006474

Septins restrict inflammation and protect zebrafish larvae from Shigella infection

Maria J. Mazon-Moya, Alexandra R. Willis, Vincenzo Torraca, Laurent Boucontet, Avinash R. Shenoy, Emma Colucci-Guyon, Serge Mostowy

PLOS Pathogens: published June 26, 2017 | https://doi.org/10.1371/journal.ppat.1006467

Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494

Jitender Kumar Verma, Ruchir Rastogi, Amitabha Mukhopadhyay

PLOS Pathogens: published June 26, 2017 | https://doi.org/10.1371/journal.ppat.1006459

A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion

Cécile Lemaître, Jhen Tsang, Caroline Bireau, Thierry Heidmann, Marie Dewannieux

PLOS Pathogens: published June 26, 2017 | https://doi.org/10.1371/journal.ppat.1006451

Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation

Jennifer Mesureur, Joana R. Feliciano, Nelly Wagner, Margarida C. Gomes, Lili Zhang, Monica Blanco-Gonzalez, Michiel van der Vaart, David O’Callaghan, Annemarie H. Meijer, Annette C. Vergunst

PLOS Pathogens: published June 26, 2017 | https://doi.org/10.1371/journal.ppat.1006437

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1. Correction: Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation

Host-derived apolipoproteins play comparable roles with viral secretory proteins E^rns and NS1 in the infectious particle formation of Flaviviridae

Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura

PLOS Pathogens: published June 23, 2017 | https://doi.org/10.1371/journal.ppat.1006475

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

Aleksandra W. Debowski, Senta M. Walton, Eng-Guan Chua, Alfred Chin-Yen Tay, Tingting Liao, Binit Lamichhane, Robyn Himbeck, Keith A. Stubbs, Barry J. Marshall, Alma Fulurija, Mohammed Benghezal

PLOS Pathogens: published June 23, 2017 | https://doi.org/10.1371/journal.ppat.1006464

Dual targeting of a virus movement protein to ER and plasma membrane subdomains is essential for plasmodesmata localization

Kazuya Ishikawa, Masayoshi Hashimoto, Akira Yusa, Hiroaki Koinuma, Yugo Kitazawa, Osamu Netsu, Yasuyuki Yamaji, Shigetou Namba

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006463

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways

Saskia Scholz, Faezzah Baharom, Gregory Rankin, Kimia T. Maleki, Shawon Gupta, Sindhu Vangeti, Jamshid Pourazar, Andrea Discacciati, Jonas Höijer, Matteo Bottai, Niklas K. Björkström, Johan Rasmuson, Magnus Evander, Anders Blomberg, Hans-Gustaf Ljunggren, Jonas Klingström, Clas Ahlm, Anna Smed-Sörensen

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006462

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

Marcela de Souza Santos, Dor Salomon, Kim Orth

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006438

Competition between influenza A virus subtypes through heterosubtypic immunity modulates re-infection and antibody dynamics in the mallard duck

Neus Latorre-Margalef, Justin D. Brown, Alinde Fojtik, Rebecca L. Poulson, Deborah Carter, Monique Franca, David E. Stallknecht

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006419

Identification of C/EBPα as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes

Anna M. Marthaler, Marta Podgorska, Pascal Feld, Alina Fingerle, Katrin Knerr-Rupp, Friedrich Grässer, Hans Smola, Klaus Roemer, Elke Ebert, Yoo-Jin Kim, Rainer M. Bohle, Cornelia S. L. Müller, Jörg Reichrath, Thomas Vogt, Magdalena Malejczyk, Sławomir Majewski, Sigrun Smola

PLOS Pathogens: published June 22, 2017 | https://doi.org/10.1371/journal.ppat.1006406

Potassium is a key signal in host-microbiome dysbiosis in periodontitis

Susan Yost, Ana E. Duran-Pinedo, Keerthana Krishnan, Jorge Frias-Lopez

PLOS Pathogens: published June 20, 2017 | https://doi.org/10.1371/journal.ppat.1006457

The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes

Susanne Kramer

PLOS Pathogens: published June 19, 2017 | https://doi.org/10.1371/journal.ppat.1006456

The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection

Philomena Ostapchuk, Maarit Suomalainen, Yueting Zheng, Karin Boucke, Urs F. Greber, Patrick Hearing

PLOS Pathogens: published June 19, 2017 | https://doi.org/10.1371/journal.ppat.1006455

The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion

Jasmin Zischke, Panagiota Mamareli, Claudia Pokoyski, Ildar Gabaev, Sabine Buyny, Roland Jacobs, Christine S. Falk, Matthias Lochner, Tim Sparwasser, Thomas F. Schulz, Penelope C. Kay-Fedorov

PLOS Pathogens: published June 19, 2017 | https://doi.org/10.1371/journal.ppat.1006454

MoEnd3 regulates appressorium formation and virulence through mediating endocytosis in rice blast fungus Magnaporthe oryzae

Xiao Li, Chuyun Gao, Lianwei Li, Muxing Liu, Ziyi Yin, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published June 19, 2017 | https://doi.org/10.1371/journal.ppat.1006449

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1. Correction: MoEnd3 regulates appressorium formation and virulence through mediating endocytosis in rice blast fungus Magnaporthe oryzae

The effector AvrRxo1 phosphorylates NAD in planta

Teja Shidore, Corey D. Broeckling, Jay S. Kirkwood, John J. Long, Jiamin Miao, Bingyu Zhao, Jan E. Leach, Lindsay R. Triplett

PLOS Pathogens: published June 19, 2017 | https://doi.org/10.1371/journal.ppat.1006442

Alpha-defensin-dependent enhancement of enteric viral infection

Sarah S. Wilson, Beth A. Bromme, Mayumi K. Holly, Mayim E. Wiens, Anshu P. Gounder, Youngmee Sul, Jason G. Smith

PLOS Pathogens: published June 16, 2017 | https://doi.org/10.1371/journal.ppat.1006446

Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury

Benkun Zou, Wei Jiang, Han Han, Jing Li, Weiying Mao, Zihui Tang, Qian Yang, Guojun Qian, Jing Qian, Wenjiao Zeng, Jie Gu, Tianqing Chu, Ning Zhu, Wenhong Zhang, Dapeng Yan, Rui He, Yiwei Chu, Mingfang Lu

PLOS Pathogens: published June 16, 2017 | https://doi.org/10.1371/journal.ppat.1006436

Wolbachia elevates host methyltransferase expression to block an RNA virus early during infection

Tamanash Bhattacharya, Irene L. G. Newton, Richard W. Hardy

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006427

Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo

Geelsu Hwang, Yuan Liu, Dongyeop Kim, Yong Li, Damian J. Krysan, Hyun Koo

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006407

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

Richard J. Kraus, Xianming Yu, Blue-leaf A. Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M. Nawandar, Shidong Ma, James C. Romero-Masters, Kyle G. McChesney, Zhen Lin, Kathleen R. Makielski, Denis L. Lee, Paul F. Lambert, Eric C. Johannsen, Shannon C. Kenney, Janet E. Mertz

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006404

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

Upeksha L. Rathnapala, Christopher D. Goodman, Geoffrey I. McFadden

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006396

Three mutations switch H7N9 influenza to human-type receptor specificity

Robert P. de Vries, Wenjie Peng, Oliver C. Grant, Andrew J. Thompson, Xueyong Zhu, Kim M. Bouwman, Alba T. Torrents de la Pena, Marielle J. van Breemen, Iresha N. Ambepitiya Wickramasinghe, Cornelis A. M. de Haan, Wenli Yu, Ryan McBride, Rogier W. Sanders, Robert J. Woods, Monique H. Verheije, Ian A. Wilson, James C. Paulson

PLOS Pathogens: published June 15, 2017 | https://doi.org/10.1371/journal.ppat.1006390

Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus

Takamasa Inoue, Billy Tsai

PLOS Pathogens: published June 14, 2017 | https://doi.org/10.1371/journal.ppat.1006439

A systemic macrophage response is required to contain a peripheral poxvirus infection

Michael L. Davies, Nikhil J. Parekh, Lauren W. Kaminsky, Chetna Soni, Irene E. Reider, Tracy E. Krouse, Matthew A. Fischer, Nico van Rooijen, Ziaur S. M. Rahman, Christopher C. Norbury

PLOS Pathogens: published June 14, 2017 | https://doi.org/10.1371/journal.ppat.1006435

Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements

Chelsie E. Armbruster, Valerie Forsyth-DeOrnellas, Alexandra O. Johnson, Sara N. Smith, Lili Zhao, Weisheng Wu, Harry L. T. Mobley

PLOS Pathogens: published June 14, 2017 | https://doi.org/10.1371/journal.ppat.1006434

Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging

Tina M. Cairns, Noah T. Ditto, Huan Lou, Benjamin D. Brooks, Doina Atanasiu, Roselyn J. Eisenberg, Gary H. Cohen

PLOS Pathogens: published June 14, 2017 | https://doi.org/10.1371/journal.ppat.1006430

Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae

Derrick R. Samuelson, Judd E. Shellito, Vincent J. Maffei, Eric D. Tague, Shawn R. Campagna, Eugene E. Blanchard, Meng Luo, Christopher M. Taylor, Martin J. J. Ronis, Patricia E. Molina, David A. Welsh

PLOS Pathogens: published June 12, 2017 | https://doi.org/10.1371/journal.ppat.1006426

MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology

Zaikun Xu, Eugene L. Asahchop, William G. Branton, Benjamin B. Gelman, Christopher Power, Tom C. Hobman

PLOS Pathogens: published June 8, 2017 | https://doi.org/10.1371/journal.ppat.1006360

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

Tiffany Benzine, Ryan Brandt, William C. Lovell, Daisuke Yamane, Petra Neddermann, Raffaele De Francesco, Stanley M. Lemon, Alan S. Perelson, Ruian Ke, David R. McGivern

PLOS Pathogens: published June 8, 2017 | https://doi.org/10.1371/journal.ppat.1006343

ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

Xiang He, Shengli Ma, Yinyin Tian, Congwen Wei, Yongjie Zhu, Feng Li, Pingping Zhang, Penghao Wang, Yanhong Zhang, Hui Zhong

PLOS Pathogens: published June 7, 2017 | https://doi.org/10.1371/journal.ppat.1006347

Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide

Audrey S. Vanhove, Saiyu Hang, Vidhya Vijayakumar, Adam CN Wong, John M. Asara, Paula I. Watnick

PLOS Pathogens: published June 6, 2017 | https://doi.org/10.1371/journal.ppat.1006428

Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis

Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler, Kirstin Harling, Norman Nausch, Malte Kohns, Ernest Adankwah, Franziska Lang, Laura Olbrich, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen

PLOS Pathogens: published June 5, 2017 | https://doi.org/10.1371/journal.ppat.1006425

HIV-1 adaptation to NK cell-mediated immune pressure

Marjet Elemans, Lies Boelen, Michael Rasmussen, Søren Buus, Becca Asquith

PLOS Pathogens: published June 5, 2017 | https://doi.org/10.1371/journal.ppat.1006361

Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion

Lingyan Jiang, Lu Feng, Bin Yang, Wenwen Zhang, Peisheng Wang, Xiaohan Jiang, Lei Wang

PLOS Pathogens: published June 2, 2017 | https://doi.org/10.1371/journal.ppat.1006429

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1. Correction: Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion

Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus

Vidya Mangala Prasad, Thomas Klose, Michael G. Rossmann

PLOS Pathogens: published June 2, 2017 | https://doi.org/10.1371/journal.ppat.1006377

Cooperative inhibition of RIP1-mediated NF-κB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit

Ki Mun Kwon, Se Eun Oh, Young Eui Kim, Tae-Hee Han, Jin-Hyun Ahn

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006423

Mitochondrial complex I bridges a connection between regulation of carbon flexibility and gastrointestinal commensalism in the human fungal pathogen Candida albicans

Xinhua Huang, Xiaoqing Chen, Yongmin He, Xiaoyu Yu, Shanshan Li, Ning Gao, Lida Niu, Yinhe Mao, Yuanyuan Wang, Xianwei Wu, Wenjuan Wu, Jianhua Wu, Dongsheng Zhou, Xiangjiang Zhan, Changbin Chen

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006414

Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein

Jianhua Zhao, Ksenia Beyrakhova, Yao Liu, Claudia P. Alvarez, Stephanie A. Bueler, Li Xu, Caishuang Xu, Michal T. Boniecki, Voula Kanelis, Zhao-Qing Luo, Miroslaw Cygler, John L. Rubinstein

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006394

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Steve J. Webster, Sven Brode, Lou Ellis, Timothy J. Fitzmaurice, Matthew J. Elder, Nelson O. Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J. S. Gaston, Jane C. Goodall

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006383

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

Patience T. Brace, Liku B. Tezera, Magdalena K. Bielecka, Toby Mellows, Diana Garay, Shuye Tian, Lucinda Rand, Justin Green, Sanjay Jogai, Andrew J. Steele, Timothy M. Millar, Tilman Sanchez-Elsner, Jon S. Friedland, Christopher G. Proud, Paul T. Elkington

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006367

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

Sabrina J. Nolan, Julia D. Romano, Isabelle Coppens

PLOS Pathogens: published June 1, 2017 | https://doi.org/10.1371/journal.ppat.1006362