Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health?

Joseph A. McBride, Rob Striker

PLOS Pathogens: published November 2, 2017 | https://doi.org/10.1371/journal.ppat.1006624

Public health risks from subclinical variant CJD

Abigail B. Diack, Robert G. Will, Jean C. Manson

PLOS Pathogens: published November 30, 2017 | https://doi.org/10.1371/journal.ppat.1006642

Poxviruses: Slipping and sliding through transcription and translation

Derek Walsh

PLOS Pathogens: published November 16, 2017 | https://doi.org/10.1371/journal.ppat.1006634

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Irruptive mammal host populations shape tularemia epidemiology

Juan J. Luque-Larena, François Mougeot, Beatriz Arroyo, Mª Dolors Vidal, Ruth Rodríguez-Pastor, Raquel Escudero, Pedro Anda, Xavier Lambin

PLOS Pathogens: published November 16, 2017 | https://doi.org/10.1371/journal.ppat.1006622

How alkalinization drives fungal pathogenicity

Tânia R. Fernandes, David Segorbe, Dov Prusky, Antonio Di Pietro

PLOS Pathogens: published November 9, 2017 | https://doi.org/10.1371/journal.ppat.1006621

Chronic wasting disease: Emerging prions and their potential risk

Samia Hannaoui, Hermann M. Schatzl, Sabine Gilch

PLOS Pathogens: published November 2, 2017 | https://doi.org/10.1371/journal.ppat.1006619

Got herpes? (Yep, you probably do!)

Eain A. Murphy

PLOS Pathogens: published November 9, 2017 | https://doi.org/10.1371/journal.ppat.1006652

Listeria monocytogenes switches from dissemination to persistence by adopting a vacuolar lifestyle in epithelial cells

Mounia Kortebi, Eliane Milohanic, Gabriel Mitchell, Christine Péchoux, Marie-Christine Prevost, Pascale Cossart, Hélène Bierne

PLOS Pathogens: published November 30, 2017 | https://doi.org/10.1371/journal.ppat.1006734

The interplay of UV and cutaneous papillomavirus infection in skin cancer development

Daniel Hasche, Sonja Stephan, Ilona Braspenning-Wesch, Julita Mikulec, Martina Niebler, Hermann-Josef Gröne, Christa Flechtenmacher, Baki Akgül, Frank Rösl, Sabrina E. Vinzón

PLOS Pathogens: published November 30, 2017 | https://doi.org/10.1371/journal.ppat.1006723

Experience-dependent olfactory behaviors of the parasitic nematode Heligmosomoides polygyrus

Felicitas Ruiz, Michelle L. Castelletto, Spencer S. Gang, Elissa A. Hallem

PLOS Pathogens: published November 30, 2017 | https://doi.org/10.1371/journal.ppat.1006709

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Ben Hu, Lei-Ping Zeng, Xing-Lou Yang, Xing-Yi Ge, Wei Zhang, Bei Li, Jia-Zheng Xie, Xu-Rui Shen, Yun-Zhi Zhang, Ning Wang, Dong-Sheng Luo, Xiao-Shuang Zheng, Mei-Niang Wang, Peter Daszak, Lin-Fa Wang, Jie Cui, Zheng-Li Shi

PLOS Pathogens: published November 30, 2017 | https://doi.org/10.1371/journal.ppat.1006698

Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells

Eloise J. O’Donoghue, Natalie Sirisaengtaksin, Douglas F. Browning, Ewa Bielska, Mohammed Hadis, Francisco Fernandez-Trillo, Luke Alderwick, Sara Jabbari, Anne Marie Krachler

PLOS Pathogens: published November 29, 2017 | https://doi.org/10.1371/journal.ppat.1006760

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek

PLOS Pathogens: published November 29, 2017 | https://doi.org/10.1371/journal.ppat.1006738

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo

Rie Furuta, Jun-ichirou Yasunaga, Michi Miura, Kenji Sugata, Akatsuki Saito, Hirofumi Akari, Takaharu Ueno, Norihiro Takenouchi, Jun-ichi Fujisawa, Ki-Ryang Koh, Yusuke Higuchi, Mohamed Mahgoub, Masakazu Shimizu, Fumihiko Matsuda, Anat Melamed, Charles R. Bangham, Masao Matsuoka

PLOS Pathogens: published November 29, 2017 | https://doi.org/10.1371/journal.ppat.1006722

H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation

Elizabeth Q. Littauer, E. Stein Esser, Olivia Q. Antao, Elena V. Vassilieva, Richard W. Compans, Ioanna Skountzou

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006757

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation

Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006752

Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes

Sheena Shah-Simpson, Gaelle Lentini, Peter C. Dumoulin, Barbara A. Burleigh

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006747

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization

Daniela Giordano, Kevin E. Draves, Lucy B. Young, Kelsey Roe, Marianne A. Bryan, Christiane Dresch, Justin M. Richner, Michael S. Diamond, Michael Gale Jr, Edward A. Clark

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006743

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Despoina Goniotaki, Asvin K. K. Lakkaraju, Amulya N. Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006733

The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues

Xiang-Yang Xue, Vladimir Majerciak, Aayushi Uberoi, Bong-Hyun Kim, Deanna Gotte, Xiongfong Chen, Maggie Cam, Paul F. Lambert, Zhi-Ming Zheng

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006715

Vaccine-elicited memory CD4⁺ T cell expansion is impaired in the lungs during tuberculosis

Stephen M. Carpenter, Jason D. Yang, Jinhee Lee, Palmira Barreira-Silva, Samuel M. Behar

PLOS Pathogens: published November 27, 2017 | https://doi.org/10.1371/journal.ppat.1006704

Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2

Tetsuji Aoyagi, Michael W. Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J. Standiford

PLOS Pathogens: published November 22, 2017 | https://doi.org/10.1371/journal.ppat.1006737

Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus

Benjamin Mielich-Süss, Rabea M. Wagner, Nicole Mietrach, Tobias Hertlein, Gabriella Marincola, Knut Ohlsen, Sebastian Geibel, Daniel Lopez

PLOS Pathogens: published November 22, 2017 | https://doi.org/10.1371/journal.ppat.1006728

Progesterone impairs antigen-non-specific immune protection by CD8 T memory cells via interferon-γ gene hypermethylation

Yushi Yao, Hui Li, Jie Ding, Yixin Xia, Lei Wang

PLOS Pathogens: published November 20, 2017 | https://doi.org/10.1371/journal.ppat.1006736

Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity

Christopher J. Alteri, Stephanie D. Himpsl, Kevin Zhu, Haley L. Hershey, Ninette Musili, Jessa E. Miller, Harry L. T. Mobley

PLOS Pathogens: published November 20, 2017 | https://doi.org/10.1371/journal.ppat.1006729

Estimating virus effective population size and selection without neutral markers

Elsa Rousseau, Benoît Moury, Ludovic Mailleret, Rachid Senoussi, Alain Palloix, Vincent Simon, Sophie Valière, Frédéric Grognard, Frédéric Fabre

PLOS Pathogens: published November 20, 2017 | https://doi.org/10.1371/journal.ppat.1006702

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang

PLOS Pathogens: published November 20, 2017 | https://doi.org/10.1371/journal.ppat.1006693

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

Thomas J. Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G. Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M. Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L. Johnson, W. Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A. Ochsner, Alan Aderem, Willem A. Hanekom, Daniel E. Zak, other members of the ACS cohort study team

PLOS Pathogens: published November 16, 2017 | https://doi.org/10.1371/journal.ppat.1006687

Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection

Lucien H. Turner, Jeremy M. Kinder, Adrienne Wilburn, Rahul J. D’Mello, Makayla R. Braunlin, Tony T. Jiang, Giang Pham, Sing Sing Way

PLOS Pathogens: published November 16, 2017 | https://doi.org/10.1371/journal.ppat.1006684

Structural basis of glycan specificity of P[19] VP8*: Implications for rotavirus zoonosis and evolution

Yang Liu, Shenyuan Xu, Andrew L. Woodruff, Ming Xia, Ming Tan, Michael A. Kennedy, Xi Jiang

PLOS Pathogens: published November 14, 2017 | https://doi.org/10.1371/journal.ppat.1006707

GDSL lipases modulate immunity through lipid homeostasis in rice

Mingjun Gao, Xin Yin, Weibing Yang, Sin Man Lam, Xiaohong Tong, Jiyun Liu, Xin Wang, Qun Li, Guanghou Shui, Zuhua He

PLOS Pathogens: published November 13, 2017 | https://doi.org/10.1371/journal.ppat.1006724

Unraveling the key to the resistance of canids to prion diseases

Natalia Fernández-Borges, Beatriz Parra, Enric Vidal, Hasier Eraña, Manuel A. Sánchez-Martín, Jorge de Castro, Saioa R. Elezgarai, Martí Pumarola, Tomás Mayoral, Joaquín Castilla

PLOS Pathogens: published November 13, 2017 | https://doi.org/10.1371/journal.ppat.1006716

Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector

Yong Chen, Qian Chen, Manman Li, Qianzhuo Mao, Hongyan Chen, Wei Wu, Dongsheng Jia, Taiyun Wei

PLOS Pathogens: published November 10, 2017 | https://doi.org/10.1371/journal.ppat.1006727

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

Run Fang, Qifei Jiang, Xiang Zhou, Chenguang Wang, Yukun Guan, Jianli Tao, Jianzhong Xi, Ji-Ming Feng, Zhengfan Jiang

PLOS Pathogens: published November 10, 2017 | https://doi.org/10.1371/journal.ppat.1006720

Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy

Eiki Sekine, Nora Schmidt, David Gaboriau, Peter O’Hare

PLOS Pathogens: published November 9, 2017 | https://doi.org/10.1371/journal.ppat.1006721

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Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components

Dustin R. Glasner, Kalani Ratnasiri, Henry Puerta-Guardo, Diego A. Espinosa, P. Robert Beatty, Eva Harris

PLOS Pathogens: published November 9, 2017 | https://doi.org/10.1371/journal.ppat.1006673

A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase

Isabelle Jupin, Maya Ayach, Lucile Jomat, Sonia Fieulaine, Stéphane Bressanelli

PLOS Pathogens: published November 8, 2017 | https://doi.org/10.1371/journal.ppat.1006714

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

Masa Ivin, Amy Dumigan, Filipe N. de Vasconcelos, Florian Ebner, Martina Borroni, Anoop Kavirayani, Kornelia N. Przybyszewska, Rebecca J. Ingram, Stefan Lienenklaus, Ulrich Kalinke, Dagmar Stoiber, Jose A. Bengoechea, Pavel Kovarik

PLOS Pathogens: published November 7, 2017 | https://doi.org/10.1371/journal.ppat.1006696

Fitness cost of reassortment in human influenza

Mara Villa, Michael Lässig

PLOS Pathogens: published November 7, 2017 | https://doi.org/10.1371/journal.ppat.1006685

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

Romel D. Mackelprang, Michael J. Bamshad, Jessica X. Chong, Xuanlin Hou, Kati J. Buckingham, Kathryn Shively, Guy deBruyn, Nelly R. Mugo, James I. Mullins, M. Juliana McElrath, Jared M. Baeten, Connie Celum, Mary J. Emond, Jairam R. Lingappa, for the Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams

PLOS Pathogens: published November 6, 2017 | https://doi.org/10.1371/journal.ppat.1006703

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Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas

Sanandan Malhotra, Shelby Winans, Gary Lam, James Justice, Robin Morgan, Karen Beemon

PLOS Pathogens: published November 3, 2017 | https://doi.org/10.1371/journal.ppat.1006708

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use

Bryony N. Parsons, Umer Z. Ijaz, Rosalinda D’Amore, Michael D. Burkitt, Richard Eccles, Luca Lenzi, Carrie A. Duckworth, Andrew R. Moore, Laszlo Tiszlavicz, Andrea Varro, Neil Hall, D. Mark Pritchard

PLOS Pathogens: published November 2, 2017 | https://doi.org/10.1371/journal.ppat.1006653

Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization

Anna D. Koromyslova, Grant S. Hansman

PLOS Pathogens: published November 2, 2017 | https://doi.org/10.1371/journal.ppat.1006636

Interaction between the flagellar pocket collar and the hook complex via a novel microtubule-binding protein in Trypanosoma brucei

Anna Albisetti, Célia Florimond, Nicolas Landrein, Keni Vidilaseris, Marie Eggenspieler, Johannes Lesigang, Gang Dong, Derrick Roy Robinson, Mélanie Bonhivers

PLOS Pathogens: published November 1, 2017 | https://doi.org/10.1371/journal.ppat.1006710