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When Plasmodium parasites are injected into the bloodstream via the bite of a mosquito, they first travel to the liver where they undergo morphological changes and rapid asexual replication before invading red blood cells and cause disease. The parasites rely on the host liver environment to undergo these changes. Immunofluorescence image of Plasmodium-infected hepatocytes show host aquaporin-3 (red) is recruited to the parasitophorous vacuole membrane of the parasites (nuclei, blue) within hepatocytes (nuclei, white). Disruption of host aquaporin-3 prevents proper parasite development. Derbyshire et al.

Image Credit: Dora Posfai and Emily Derbyshire, Duke University

Opinion

Does pathogen plasticity facilitate host shifts?

Henrik H. De Fine Licht

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1006961

Pearls

RNA virus building blocks—miRNAs not included

Lauren C. Aguado, Benjamin tenOever

PLOS Pathogens: published May 31, 2018 | https://doi.org/10.1371/journal.ppat.1006963

Lessons from bacteriophages part 1: Deriving utility from protein structure, function, and evolution

Kunica Asija, Carolyn M. Teschke

PLOS Pathogens: published May 17, 2018 | https://doi.org/10.1371/journal.ppat.1006971

Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health

Kunica Asija, Carolyn M. Teschke

PLOS Pathogens: published May 17, 2018 | https://doi.org/10.1371/journal.ppat.1006970

Lipids and pathogenic flaviviruses: An intimate union

Hans C. Leier, William B. Messer, Fikadu G. Tafesse

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1006952

Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles

J. Kennon Smith, Mavis Agbandje-McKenna

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1006929

Research Matters

Omissions from a National Institute of Health (NIH) biosketch

Alice Prince

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1006896

Research Articles

Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques

Daniel R. Ram, Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, R. Keith Reeves

PLOS Pathogens: published May 31, 2018 | https://doi.org/10.1371/journal.ppat.1007104

PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

Jake Jianjun Wen, Yuhui Whitney Yin, Nisha Jain Garg

PLOS Pathogens: published May 31, 2018 | https://doi.org/10.1371/journal.ppat.1007065

Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye

Valentina Voigt, Christopher E. Andoniou, Iona S. Schuster, Anna Oszmiana, Monique L. Ong, Peter Fleming, John V. Forrester, Mariapia A. Degli-Esposti

PLOS Pathogens: published May 31, 2018 | https://doi.org/10.1371/journal.ppat.1007040

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing

Cristina Faralla, Effie E. Bastounis, Fabian E. Ortega, Samuel H. Light, Gabrielle Rizzuto, Lei Gao, Denise K. Marciano, Salvatore Nocadello, Wayne F. Anderson, Jennifer R. Robbins, Julie A. Theriot, Anna I. Bakardjiev

PLOS Pathogens: published May 30, 2018 | https://doi.org/10.1371/journal.ppat.1007094

De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions

Yoann Millerioux, Muriel Mazet, Guillaume Bouyssou, Stefan Allmann, Tiila-Riikka Kiema, Eloïse Bertiaux, Laetitia Fouillen, Chandan Thapa, Marc Biran, Nicolas Plazolles, Franziska Dittrich-Domergue, Aline Crouzols, Rik K. Wierenga, Brice Rotureau, Patrick Moreau, Frédéric Bringaud

PLOS Pathogens: published May 29, 2018 | https://doi.org/10.1371/journal.ppat.1007116

Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission

Thomas Hart, Ngoc Thien Thu Nguyen, Nancy A. Nowak, Fuming Zhang, Robert J. Linhardt, Maria Diuk-Wasser, Sanjay Ram, Peter Kraiczy, Yi-Pin Lin

PLOS Pathogens: published May 29, 2018 | https://doi.org/10.1371/journal.ppat.1007106

An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum

Tai An, Ziyin Li

PLOS Pathogens: published May 29, 2018 | https://doi.org/10.1371/journal.ppat.1007101

IL-17 can be protective or deleterious in murine pneumococcal pneumonia

Neil D. Ritchie, Ryan Ritchie, Hannah K. Bayes, Tim J. Mitchell, Tom J. Evans

PLOS Pathogens: published May 29, 2018 | https://doi.org/10.1371/journal.ppat.1007099

Continuous DNA replication is required for late gene transcription and maintenance of replication compartments in gammaherpesviruses

Dajiang Li, Wenmin Fu, Sankar Swaminathan

PLOS Pathogens: published May 29, 2018 | https://doi.org/10.1371/journal.ppat.1007070

A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii

Edward Geisinger, Nadav J. Mortman, Germán Vargas-Cuebas, Albert K. Tai, Ralph R. Isberg

PLOS Pathogens: published May 24, 2018 | https://doi.org/10.1371/journal.ppat.1007030

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Jinyong Wang, Manoranjan Sahoo, Louis Lantier, Jonathan Warawa, Hector Cordero, Kelly Deobald, Fabio Re

PLOS Pathogens: published May 23, 2018 | https://doi.org/10.1371/journal.ppat.1007105

Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs

Lauren M. Hook, Tina M. Cairns, Sita Awasthi, Benjamin D. Brooks, Noah T. Ditto, Roselyn J. Eisenberg, Gary H. Cohen, Harvey M. Friedman

PLOS Pathogens: published May 23, 2018 | https://doi.org/10.1371/journal.ppat.1007095

A novel mouse model of Campylobacter jejuni enteropathy and diarrhea

Natasa Giallourou, Gregory L. Medlock, David T. Bolick, Pedro HQS Medeiros, Solanka E. Ledwaba, Glynis L. Kolling, Kenneth Tung, Patricia Guerry, Jonathan R. Swann, Richard L. Guerrant

PLOS Pathogens: published May 23, 2018 | https://doi.org/10.1371/journal.ppat.1007083

SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy

Muyu Xu, James J. Moresco, Max Chang, Amey Mukim, Davey Smith, Jolene K. Diedrich, John R. Yates III, Katherine A. Jones

PLOS Pathogens: published May 23, 2018 | https://doi.org/10.1371/journal.ppat.1007071

Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein

Sravani Banerjee, David Aponte-Diaz, Calvin Yeager, Suresh D. Sharma, Gang Ning, Hyung S. Oh, Qingxia Han, Masato Umeda, Yuji Hara, Robert Y. L. Wang, Craig E. Cameron

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007086

Multiple roles of core protein linker in hepatitis B virus replication

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PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007085

Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007075

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections

J. Scott Fites, Michael Gui, John F. Kernien, Paige Negoro, Zeina Dagher, David B. Sykes, Jeniel E. Nett, Michael K. Mansour, Bruce S. Klein

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007073

Langerin⁺ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection

Florian Sparber, Tamas Dolowschiak, Sarah Mertens, Laura Lauener, Björn E. Clausen, Nicole Joller, Patrizia Stoitzner, Roxane Tussiwand, Salomé LeibundGut-Landmann

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007069

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

David Roquis, Aaron Taudt, Kathrin K. Geyer, Gilda Padalino, Karl F. Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007066

Mycobacterium tuberculosis-specific CD4⁺ and CD8⁺ T cells differ in their capacity to recognize infected macrophages

Jason D. Yang, Daniel Mott, Rujapak Sutiwisesak, Yu-Jung Lu, Fiona Raso, Britni Stowell, Greg Hunter Babunovic, Jinhee Lee, Steve M. Carpenter, Sing Sing Way, Sarah M. Fortune, Samuel M. Behar

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007060

Role of kinesins in directed adenovirus transport and cytoplasmic exploration

Jie Zhou, Julian Scherer, Julie Yi, Richard B. Vallee

PLOS Pathogens: published May 21, 2018 | https://doi.org/10.1371/journal.ppat.1007055

Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity

Victoria A. Marko, Sara L. N. Kilmury, Lesley T. MacNeil, Lori L. Burrows

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1007074

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection

Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G. Ganley, Johannes Wirth, Quinlan E. Cullen, Tushar Dave, Nobutaka Kato, Sandeep S. Dave, Emily R. Derbyshire

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1007057

Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria

Ruizheng Shi, Zehong Cao, Hong Li, Jochen Graw, Guogang Zhang, Victor J. Thannickal, Guangjie Cheng

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1007026

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals

Nuria Trevijano-Contador, Haroldo Cesar de Oliveira, Rocío García-Rodas, Suélen Andreia Rossi, Irene Llorente, Ángel Zaballos, Guilhem Janbon, Joaquín Ariño, Óscar Zaragoza

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1007007

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Benjamin Hommel, Liliane Mukaremera, Radames J. B. Cordero, Carolina Coelho, Christopher A. Desjardins, Aude Sturny-Leclère, Guilhem Janbon, John R. Perfect, James A. Fraser, Arturo Casadevall, Christina A. Cuomo, Françoise Dromer, Kirsten Nielsen, Alexandre Alanio

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1006982

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

Ivy M. Dambuza, Thomas Drake, Ambre Chapuis, Xin Zhou, Joao Correia, Leanne Taylor-Smith, Nathalie LeGrave, Tim Rasmussen, Matthew C. Fisher, Tihana Bicanic, Thomas S. Harrison, Marcel Jaspars, Robin C. May, Gordon D. Brown, Raif Yuecel, Donna M. MacCallum, Elizabeth R. Ballou

PLOS Pathogens: published May 18, 2018 | https://doi.org/10.1371/journal.ppat.1006978

Shape-shifting trypanosomes: Flagellar shortening followed by asymmetric division in Trypanosoma congolense from the tsetse proventriculus

Lori Peacock, Christopher Kay, Mick Bailey, Wendy Gibson

PLOS Pathogens: published May 17, 2018 | https://doi.org/10.1371/journal.ppat.1007043

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

Katie Tungatt, Garry Dolton, Sophie B. Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D. Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A. Hammond, John J. Miles, David K. Cole, Alain Townsend, Mick Bailey, Pierre J. Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K. Sewell

PLOS Pathogens: published May 17, 2018 | https://doi.org/10.1371/journal.ppat.1007017

Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection

Xiaogang Feng, Cajsa Classon, Graciela Terán, Yunlong Yang, Lei Li, Sherwin Chan, Ulf Ribacke, Antonio Gigliotti Rothfuchs, Jonathan M. Coquet, Susanne Nylén

PLOS Pathogens: published May 17, 2018 | https://doi.org/10.1371/journal.ppat.1007008

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite

Christine Lehmann, Michele Ser Ying Tan, Laura E. de Vries, Ilaria Russo, Mateo I. Sanchez, Daniel E. Goldberg, Edgar Deu

PLOS Pathogens: published May 16, 2018 | https://doi.org/10.1371/journal.ppat.1007031

RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization

David G. Glanville, Lanlan Han, Andrew F. Maule, Alexandra Woodacre, Devsaagar Thanki, Iman Tajer Abdullah, Julie A. Morrissey, Thomas B. Clarke, Hasan Yesilkaya, Nicholas R. Silvaggi, Andrew T. Ulijasz

PLOS Pathogens: published May 11, 2018 | https://doi.org/10.1371/journal.ppat.1007052

Metabolic reprogramming of Kaposi’s sarcoma associated herpes virus infected B-cells in hypoxia

Rajnish Kumar Singh, Fengchao Lang, Yonggang Pei, Hem Chandra Jha, Erle S. Robertson

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1007062

Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex

Young Bong Choi, Yeeun Choi, Edward William Harhaj

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1007058

The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection

Priya Uppuluri, Lin Lin, Abdullah Alqarihi, Guanpingsheng Luo, Eman G. Youssef, Sondus Alkhazraji, Nannette Y. Yount, Belal A. Ibrahim, Michael Anthony Bolaris, John E. Edwards Jr., Marc Swidergall, Scott G. Filler, Michael R. Yeaman, Ashraf S. Ibrahim

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1007056

Assembly-hub function of ER-localized SNARE proteins in biogenesis of tombusvirus replication compartment

Zsuzsanna Sasvari, Nikolay Kovalev, Paulina Alatriste Gonzalez, Kai Xu, Peter D. Nagy

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1007028

p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila

Cara West, Neal Silverman

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1007020

Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe

Verena J. Schuenemann, Charlotte Avanzi, Ben Krause-Kyora, Alexander Seitz, Alexander Herbig, Sarah Inskip, Marion Bonazzi, Ella Reiter, Christian Urban, Dorthe Dangvard Pedersen, G. Michael Taylor, Pushpendra Singh, Graham R. Stewart, Petr Velemínský, Jakub Likovsky, Antónia Marcsik, Erika Molnár, György Pálfi, Valentina Mariotti, Alessandro Riga, M. Giovanna Belcastro, Jesper L. Boldsen, Almut Nebel, Simon Mays, Helen D. Donoghue, Sonia Zakrzewski, Andrej Benjak, Kay Nieselt, Stewart T. Cole, Johannes Krause

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1006997

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

Torben Schiffner, Jesper Pallesen, Rebecca A. Russell, Jonathan Dodd, Natalia de Val, Celia C. LaBranche, David Montefiori, Georgia D. Tomaras, Xiaoying Shen, Scarlett L. Harris, Amin E. Moghaddam, Oleksandr Kalyuzhniy, Rogier W. Sanders, Laura E. McCoy, John P. Moore, Andrew B. Ward, Quentin J. Sattentau

PLOS Pathogens: published May 10, 2018 | https://doi.org/10.1371/journal.ppat.1006986

The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B

Jillian C. Carmichael, Hiroki Yokota, Rebecca C. Craven, Anthony Schmitt, John W. Wills

PLOS Pathogens: published May 9, 2018 | https://doi.org/10.1371/journal.ppat.1007054

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings

André Lin Ouédraogo, Philip A. Eckhoff, Adrian J. F. Luty, Will Roeffen, Robert W. Sauerwein, Teun Bousema, Edward A. Wenger

PLOS Pathogens: published May 9, 2018 | https://doi.org/10.1371/journal.ppat.1007034

Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

Liting Zhang, Jin Liu, Liping Qian, Qian Feng, Xiaofang Wang, Yukang Yuan, Yibo Zuo, Qiao Cheng, Ying Miao, Tingting Guo, Xiaofeng Zheng, Hui Zheng

PLOS Pathogens: published May 7, 2018 | https://doi.org/10.1371/journal.ppat.1007067

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection

Saravanan Raju, Kohei Kometani, Tomohiro Kurosaki, Andrey S. Shaw, Takeshi Egawa

PLOS Pathogens: published May 7, 2018 | https://doi.org/10.1371/journal.ppat.1007053

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation

Sean M. Evans, Kyle G. Rodino, Haley E. Adcox, Jason A. Carlyon

PLOS Pathogens: published May 7, 2018 | https://doi.org/10.1371/journal.ppat.1007023

Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry

Charlotte Ford, Andrea Nans, Emmanuel Boucrot, Richard D. Hayward

PLOS Pathogens: published May 4, 2018 | https://doi.org/10.1371/journal.ppat.1007051

The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice

Etai Rotem, Omri Faingold, Meital Charni, Yoel A. Klug, Daniel Harari, Liraz Shmuel-Galia, Alon Nudelman, Varda Rotter, Yechiel Shai

PLOS Pathogens: published May 4, 2018 | https://doi.org/10.1371/journal.ppat.1007044

Biphasic zinc compartmentalisation in a human fungal pathogen

Aaron C. Crawford, Laura E. Lehtovirta-Morley, Omran Alamir, Maria J. Niemiec, Bader Alawfi, Mohammad Alsarraf, Volha Skrahina, Anna C. B. P. Costa, Andrew Anderson, Sujan Yellagunda, Elizabeth R. Ballou, Bernhard Hube, Constantin F. Urban, Duncan Wilson

PLOS Pathogens: published May 4, 2018 | https://doi.org/10.1371/journal.ppat.1007013

Prion protein protects mice from lethal infection with influenza A viruses

Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Nandita Rani Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido, Suehiro Sakaguchi

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1007049

ESCRT machinery components are required for Orthobunyavirus particle production in Golgi compartments

Natalia S. Barbosa, Leila R. Mendonça, Marcos V. S. Dias, Marjorie C. Pontelli, Elaine Z. M. da Silva, Miria F. Criado, Mara E. da Silva-Januário, Michael Schindler, Maria C. Jamur, Constance Oliver, Eurico Arruda, Luis L. P. daSilva

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1007047

Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection

Ines Martin-Martin, Andrezza Campos Chagas, Anderson B. Guimaraes-Costa, Laura Amo, Fabiano Oliveira, Ian N. Moore, Thiago S. DeSouza-Vieira, Elda E. Sanchez, Montamas Suntravat, Jesus G. Valenzuela, Jose M. C. Ribeiro, Eric Calvo

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1007006

Contributions from the silent majority dominate dengue virus transmission

Quirine A. ten Bosch, Hannah E. Clapham, Louis Lambrechts, Veasna Duong, Philippe Buchy, Benjamin M. Althouse, Alun L. Lloyd, Lance A. Waller, Amy C. Morrison, Uriel Kitron, Gonzalo M. Vazquez-Prokopec, Thomas W. Scott, T. Alex Perkins

PLOS Pathogens: published May 3, 2018 | https://doi.org/10.1371/journal.ppat.1006965

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency

Daniel Stern, Jasmin Weisemann, Alexander Le Blanc, Laura von Berg, Stefan Mahrhold, Janett Piesker, Michael Laue, Peter B. Luppa, Martin Bernhard Dorner, Brigitte Gertrud Dorner, Andreas Rummel

PLOS Pathogens: published May 2, 2018 | https://doi.org/10.1371/journal.ppat.1007048

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

Joshua B. Radke, Danielle Worth, David Hong, Sherri Huang, William J. Sullivan Jr., Emma H. Wilson, Michael W. White

PLOS Pathogens: published May 2, 2018 | https://doi.org/10.1371/journal.ppat.1007035

Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

Ema T. Crooks, Samantha L. Grimley, Michelle Cully, Keiko Osawa, Gillian Dekkers, Kevin Saunders, Sebastian Rämisch, Sergey Menis, William R. Schief, Nicole Doria-Rose, Barton Haynes, Ben Murrell, Evan Mitchel Cale, Amarendra Pegu, John R. Mascola, Gestur Vidarsson, James M. Binley

PLOS Pathogens: published May 2, 2018 | https://doi.org/10.1371/journal.ppat.1007024

Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

Alexandra Blanchard, Fabrice Guégnard, Claude L. Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O’Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J. Wolstenholme, Robin N. Beech, Lindy Holden-Dye, Cedric Neveu

PLOS Pathogens: published May 2, 2018 | https://doi.org/10.1371/journal.ppat.1006996

May 2018

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Plasmodium parasites recruit host aquaporin-3 for proper development

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