Parasite microbiome project: Grand challenges

Nolwenn M. Dheilly, Joaquín Martínez Martínez, Karyna Rosario, Paul J. Brindley, Raina N. Fichorova, Jonathan Z. Kaye, Kevin D. Kohl, Laura J. Knoll, Julius Lukeš, Susan L. Perkins, Robert Poulin, Lynn Schriml, Luke R. Thompson

PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1008028

Does rotavirus turn on type 1 diabetes?

Leonard C. Harrison, Kirsten P. Perrett, Kim Jachno, Terry M. Nolan, Margo C. Honeyman

PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1007965

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses

Koen Sedeyn, Bert Schepens, Xavier Saelens

PLOS Pathogens: published October 17, 2019 | https://doi.org/10.1371/journal.ppat.1007984

Diet–microbiome–disease: Investigating diet’s influence on infectious disease resistance through alteration of the gut microbiome

Erica V. Harris, Jacobus C. de Roode, Nicole M. Gerardo

PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1007891

Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain

James Hadfield, Anderson F. Brito, Daniele M. Swetnam, Chantal B. F. Vogels, Ryan E. Tokarz, Kristian G. Andersen, Ryan C. Smith, Trevor Bedford, Nathan D. Grubaugh

PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1008042

Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer

Kuang-Yu Chen, Emmanuel Dos Santos Afonso, Vincent Enouf, Catherine Isel, Nadia Naffakh

PLOS Pathogens: published October 3, 2019 | https://doi.org/10.1371/journal.ppat.1008034

Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids

Stephen F. Fitzgerald, Amy E. Beckett, Javier Palarea-Albaladejo, Sean McAteer, Sharif Shaaban, Jason Morgan, Nur Indah Ahmad, Rachel Young, Neil A. Mabbott, Liam Morrison, James L. Bono, David L. Gally, Tom N. McNeilly

PLOS Pathogens: published October 3, 2019 | https://doi.org/10.1371/journal.ppat.1008003

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

Fanhua Wei, Zhimin Jiang, Honglei Sun, Juan Pu, Yipeng Sun, Mingyang Wang, Qi Tong, Yuhai Bi, Xiaojing Ma, George Fu Gao, Jinhua Liu

PLOS Pathogens: published October 4, 2019 | https://doi.org/10.1371/journal.ppat.1008062

Related Articles

1. Correction: Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

David F. Read, Edmond Atindaana, Kalyani Pyaram, Feng Yang, Sarah Emery, Anna Cheong, Katherine R. Nakama, Cleo Burnett, Erin T. Larragoite, Emilie Battivelli, Eric Verdin, Vicente Planelles, Cheong-Hee Chang, Alice Telesnitsky, Jeffrey M. Kidd

PLOS Pathogens: published October 4, 2019 | https://doi.org/10.1371/journal.ppat.1007903

Alterations in cellular expression in EBV infected epithelial cell lines and tumors

Rachel Hood Edwards, Robert Dekroon, Nancy Raab-Traub

PLOS Pathogens: published October 4, 2019 | https://doi.org/10.1371/journal.ppat.1008071

Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion

Eric T. Sumrall, Yang Shen, Anja P. Keller, Jeanine Rismondo, Maria Pavlou, Marcel R. Eugster, Samy Boulos, Olivier Disson, Pierre Thouvenot, Samuel Kilcher, Bernd Wollscheid, Didier Cabanes, Marc Lecuit, Angelika Gründling, Martin J. Loessner

PLOS Pathogens: published October 7, 2019 | https://doi.org/10.1371/journal.ppat.1008032

Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry

Remigiusz A. Serwa, Eiki Sekine, Jonathan Brown, Su Hui Catherine Teo, Edward W. Tate, Peter O’Hare

PLOS Pathogens: published October 7, 2019 | https://doi.org/10.1371/journal.ppat.1007956

Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids

Alexandre B. Leitão, Xueni Bian, Jonathan P. Day, Simone Pitton, Eşref Demir, Francis M. Jiggins

PLOS Pathogens: published October 7, 2019 | https://doi.org/10.1371/journal.ppat.1008084

Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

Mohammad Zeeshan, Fiona Shilliday, Tianyang Liu, Steven Abel, Tobias Mourier, David J. P. Ferguson, Edward Rea, Rebecca R. Stanway, Magali Roques, Desiree Williams, Emilie Daniel, Declan Brady, Anthony J. Roberts, Anthony A. Holder, Arnab Pain, Karine G. Le Roch, Carolyn A. Moores, Rita Tewari

PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1008048

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

Nannan Wu, Xuan-Nhi Nguyen, Li Wang, Romain Appourchaux, Chengfei Zhang, Baptiste Panthu, Henri Gruffat, Chloé Journo, Sandrine Alais, Juliang Qin, Na Zhang, Kevin Tartour, Frédéric Catez, Renaud Mahieux, Theophile Ohlmann, Mingyao Liu, Bing Du, Andrea Cimarelli

PLOS Pathogens: published October 10, 2019 | https://doi.org/10.1371/journal.ppat.1008093

Related Articles

1. Correction: The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden

Nikhil J. Parekh, Tracy E. Krouse, Irene E. Reider, Ryan P. Hobbs, Brian M. Ward, Christopher C. Norbury

PLOS Pathogens: published October 11, 2019 | https://doi.org/10.1371/journal.ppat.1007778

Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG

Ogan K. Kumova, Adam J. Fike, Jillian L. Thayer, Linda T. Nguyen, Joshua Chang Mell, Judy Pascasio, Christopher Stairiker, Leticia G. Leon, Peter D. Katsikis, Alison J. Carey

PLOS Pathogens: published October 11, 2019 | https://doi.org/10.1371/journal.ppat.1008072

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

Liu Cao, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo, Xiaolong Guo, Yongjia Tong, Xiaolu Zhao, Chun-Mei Li, Yu Chen, Deyin Guo

PLOS Pathogens: published October 11, 2019 | https://doi.org/10.1371/journal.ppat.1008079

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals

Elizabeth R. Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J. Bale, Mars Stone, Rebecca Hoh, Mary F. Kearney, Frank Maldarelli, Steven G. Deeks, Michael P. Busch, Roger G. Ptak, Deanna A. Kulpa

PLOS Pathogens: published October 14, 2019 | https://doi.org/10.1371/journal.ppat.1008074

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly

Jessica A. Slade, Mary Brockett, Raghuveer Singh, George W. Liechti, Anthony T. Maurelli

PLOS Pathogens: published October 17, 2019 | https://doi.org/10.1371/journal.ppat.1008078

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence

Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L. Harper, Colin T. King, Luca Micci, Barbara Cervasi, Joseph C. Mudd, Kiran P. Gill, Sherrie M. Jean, Kirk Easley, Guido Silvestri, Jacob D. Estes, Constantinos Petrovas, Michael M. Lederman, Mirko Paiardini

PLOS Pathogens: published October 18, 2019 | https://doi.org/10.1371/journal.ppat.1008081

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA

Bianca Dauber, Holly A. Saffran, James R. Smiley

PLOS Pathogens: published October 18, 2019 | https://doi.org/10.1371/journal.ppat.1008111

A three-dimensional RNA motif mediates directional trafficking of Potato spindle tuber viroid from epidermal to palisade mesophyll cells in Nicotiana benthamiana

Jian Wu, Neocles B. Leontis, Craig L. Zirbel, David M. Bisaro, Biao Ding

PLOS Pathogens: published October 23, 2019 | https://doi.org/10.1371/journal.ppat.1008147

Related Articles

1. Correction: A three-dimensional RNA motif mediates directional trafficking of Potato spindle tuber viroid from epidermal to palisade mesophyll cells in Nicotiana benthamiana

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

Hasier Eraña, Jorge M. Charco, Michele A. Di Bari, Carlos M. Díaz-Domínguez, Rafael López-Moreno, Enric Vidal, Ezequiel González-Miranda, Miguel A. Pérez-Castro, Sandra García-Martínez, Susana Bravo, Natalia Fernández-Borges, Mariví Geijo, Claudia D’Agostino, Joseba Garrido, Jifeng Bian, Anna König, Boran Uluca-Yazgi, Raimon Sabate, Vadim Khaychuk, Ilaria Vanni, Glenn C. Telling, Henrike Heise, Romolo Nonno, Jesús R. Requena, Joaquín Castilla

PLOS Pathogens: published October 23, 2019 | https://doi.org/10.1371/journal.ppat.1008117

Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection

Patrick Younan, Rodrigo I. Santos, Palaniappan Ramanathan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Tatiana Ammosova, Michelle Meyer, Michael G. Katze, Vsevolod L. Popov, Sergei Nekhai, Alexander Bukreyev

PLOS Pathogens: published October 24, 2019 | https://doi.org/10.1371/journal.ppat.1008068

Co-opting the fermentation pathway for tombusvirus replication: Compartmentalization of cellular metabolic pathways for rapid ATP generation

Wenwu Lin, Yuyan Liu, Melissa Molho, Shengjie Zhang, Longshen Wang, Lianhui Xie, Peter D. Nagy

PLOS Pathogens: published October 24, 2019 | https://doi.org/10.1371/journal.ppat.1008092

The ROP16_III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival

Shraddha Tuladhar, Joshua A. Kochanowsky, Apoorva Bhaskara, Yarah Ghotmi, Sambamurthy Chandrasekaran, Anita A. Koshy

PLOS Pathogens: published October 24, 2019 | https://doi.org/10.1371/journal.ppat.1007856

Cell autonomous and non-autonomous functions of plant intracellular immune receptors in stomatal defense and apoplastic defense

Jiapei Yan, Huiyun Yu, Bo Li, Anqi Fan, Jeffrey Melkonian, Xiue Wang, Tong Zhou, Jian Hua

PLOS Pathogens: published October 25, 2019 | https://doi.org/10.1371/journal.ppat.1008094

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

Frédéric D. Chevalier, Winka Le Clec’h, Marina McDew-White, Vinay Menon, Meghan A. Guzman, Stephen P. Holloway, Xiaohang Cao, Alexander B. Taylor, Safari Kinung'hi, Anouk N. Gouvras, Bonnie L. Webster, Joanne P. Webster, Aidan M. Emery, David Rollinson, Amadou Garba Djirmay, Khalid M. Al Mashikhi, Salem Al Yafae, Mohamed A. Idris, Hélène Moné, Gabriel Mouahid, P. John Hart, Philip T. LoVerde, Timothy J. C. Anderson

PLOS Pathogens: published October 25, 2019 | https://doi.org/10.1371/journal.ppat.1007881

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites

Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B. Ascher, Bethany Mason, Gerbrand J. van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C. S. Lee, Katerina Artavanis-Tsakonas

PLOS Pathogens: published October 28, 2019 | https://doi.org/10.1371/journal.ppat.1008086

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies

Ludmila Perelygina, Min-hsin Chen, Suganthi Suppiah, Adebola Adebayo, Emily Abernathy, Morna Dorsey, Lionel Bercovitch, Kenneth Paris, Kevin P. White, Alfons Krol, Julie Dhossche, Ivan Y. Torshin, Natalie Saini, Leszek J. Klimczak, Dmitry A. Gordenin, Andrey Zharkikh, Stanley Plotkin, Kathleen E. Sullivan, Joseph Icenogle

PLOS Pathogens: published October 28, 2019 | https://doi.org/10.1371/journal.ppat.1008080

Cooperativity between the 3’ untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus

Derek W. Trobaugh, Chengqun Sun, Nishank Bhalla, Christina L. Gardner, Matthew D. Dunn, William B. Klimstra

PLOS Pathogens: published October 28, 2019 | https://doi.org/10.1371/journal.ppat.1007867

USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection

Xavier Dagenais-Lussier, Hamza Loucif, Hugo Cadorel, Juliette Blumberger, Stéphane Isnard, Mariana Gé Bego, Éric A. Cohen, Jean-Pierre Routy, Julien van Grevenynghe, for the Montreal Primary Infection Study Group

PLOS Pathogens: published October 28, 2019 | https://doi.org/10.1371/journal.ppat.1008060

Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape

Abimbola O. Kolawole, Carmen Mirabelli, David R. Hill, Sophia A. Svoboda, Andrew B. Janowski, Karla D. Passalacqua, Benancio N. Rodriguez, Michael K. Dame, Pamela Freiden, Ryan P. Berger, Diem-lan Vu, Myra Hosmillo, Mary X. D. O’Riordan, Stacey Schultz-Cherry, Susana Guix, Jason R. Spence, David Wang, Christiane E. Wobus

PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1008057

A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment

Thomas Günther, Jacqueline Fröhlich, Christina Herrde, Shinji Ohno, Lia Burkhardt, Heiko Adler, Adam Grundhoff

PLOS Pathogens: published October 31, 2019 | https://doi.org/10.1371/journal.ppat.1007838

Correction: A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

Yan Sun, Eun Ji Kim, Sébastien A. Felt, Louis J. Taylor, Divyansh Agarwal, Gregory R. Grant, Carolina B. López

PLOS Pathogens: published October 3, 2019 | https://doi.org/10.1371/journal.ppat.1008099

Related Articles

1. A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

Correction: Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster

Susanna Valanne, Tiina S. Salminen, Mirva Järvelä-Stölting, Laura Vesala, Mika Rämet

PLOS Pathogens: published October 4, 2019 | https://doi.org/10.1371/journal.ppat.1008088

Related Articles

1. Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster