Tackling protozoan parasites of cattle in sub-Saharan Africa

Paula MacGregor, Vishvanath Nene, R. Ellen R. Nisbet

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009955

Pro-domain processing of fungal effector proteins from plant pathogens

Megan A. Outram, Peter S. Solomon, Simon J. Williams

PLOS Pathogens: published October 20, 2021 | https://doi.org/10.1371/journal.ppat.1010000

Pathogenesis insights from an ancient and ubiquitous spirochete

Jenifer Coburn, Mathieu Picardeau, Christopher W. Woods, Timothy Veldman, David A. Haake

PLOS Pathogens: published October 21, 2021 | https://doi.org/10.1371/journal.ppat.1009836

The power of poop: Defecation behaviors and social hygiene in insects

Marissa E. Cole, Javier A. Ceja-Navarro, Aram Mikaelyan

PLOS Pathogens: published October 28, 2021 | https://doi.org/10.1371/journal.ppat.1009964

Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein

Laura Medina-Puche, Anelise F. Orílio, F. Murilo Zerbini, Rosa Lozano-Durán

PLOS Pathogens: published October 7, 2021 | https://doi.org/10.1371/journal.ppat.1009915

Deconstructing virus condensation

Nora Lopez, Gabriela Camporeale, Mariano Salgueiro, Silvia Susana Borkosky, Araceli Visentín, Ramon Peralta-Martinez, María Eugenia Loureiro, Gonzalo de Prat-Gay

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009926

A short chain fatty acid–centric view of Clostridioides difficile pathogenesis

Anna L. Gregory, Daniel A. Pensinger, Andrew J. Hryckowian

PLOS Pathogens: published October 21, 2021 | https://doi.org/10.1371/journal.ppat.1009959

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLOS Pathogens: published October 1, 2021 | https://doi.org/10.1371/journal.ppat.1009412

Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade

Lindsay M. Snyder, Claire M. Doherty, Heather L. Mercer, Eric Y. Denkers

PLOS Pathogens: published October 1, 2021 | https://doi.org/10.1371/journal.ppat.1009970

Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases

Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Jean-Marie Launay, Gerold Schmitt-Ulms, Benoit Schneider

PLOS Pathogens: published October 5, 2021 | https://doi.org/10.1371/journal.ppat.1009991

Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer, Alexandra Leutbecher, Lina Wolfram, Lisa Rausch, Jan Kranich, Paul R. Wratil, Johanna E. Huber, Dirk Baumjohann, Simon Rothenfusser, Benjamin Schubert, Anne Hilgendorff, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Michael von Bergwelt-Baildon, Konstantin Stark, Tobias Straub, Thomas Brocker, Oliver T. Keppler, Marion Subklewe, Anne B. Krug

PLOS Pathogens: published October 6, 2021 | https://doi.org/10.1371/journal.ppat.1009742

CXCR6⁺CD4⁺ T cells promote mortality during Trypanosoma brucei infection

Gongguan Liu, Osama Abas, Ashley B. Strickland, Yanli Chen, Meiqing Shi

PLOS Pathogens: published October 6, 2021 | https://doi.org/10.1371/journal.ppat.1009968

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

Mathias Diehl, Lena Roling, Lukas Rohland, Sebastian Weber, Marek Cyrklaff, Cecilia P. Sanchez, Carlo A. Beretta, Caroline S. Simon, Julien Guizetti, Julia Hahn, Norma Schulz, Matthias P. Mayer, Jude M. Przyborski

PLOS Pathogens: published October 6, 2021 | https://doi.org/10.1371/journal.ppat.1009969

The novel ORFV protein ORFV113 activates LPA-p38 signaling

Sushil Khatiwada, Gustavo Delhon, Sabal Chaulagain, Daniel L. Rock

PLOS Pathogens: published October 6, 2021 | https://doi.org/10.1371/journal.ppat.1009971

Low-dose IL-2 therapy invigorates CD8⁺ T cells for viral control in systemic lupus erythematosus

Pengcheng Zhou, Jiali Chen, Jing He, Ting Zheng, Joseph Yunis, Victor Makota, Yannick O. Alexandre, Fang Gong, Xia Zhang, Wuxiang Xie, Yuhui Li, Miao Shao, Yanshan Zhu, Jane E. Sinclair, Miao Miao, Yaping Chen, Kirsty R. Short, Scott N. Mueller, Xiaolin Sun, Di Yu, Zhanguo Li

PLOS Pathogens: published October 7, 2021 | https://doi.org/10.1371/journal.ppat.1009858

Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses

Kaitlyn Waters, Cheng Gao, Matthew Ykema, Lei Han, Lynden Voth, Yizhi Jane Tao, Xiu-Feng Wan

PLOS Pathogens: published October 7, 2021 | https://doi.org/10.1371/journal.ppat.1009962

PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes

Jessica L. Kelliher, Caroline M. Grunenwald, Rhiannon R. Abrahams, McKenzie E. Daanen, Cassandra I. Lew, Warren E. Rose, John-Demian Sauer

PLOS Pathogens: published October 8, 2021 | https://doi.org/10.1371/journal.ppat.1009881

Differential pathogenesis of closely related 2018 Nigerian outbreak clade III Lassa virus isolates

Derek R. Stein, Bryce M. Warner, Jonathan Audet, Geoff Soule, Vinayakumar Siragam, Patrycja Sroga, Bryan D. Griffin, Anders Leung, Allen Grolla, Kevin Tierney, Alix Albietz, Darwyn Kobasa, Abdulmajid S. Musa, Adama Ahmad, Afolabi M. Akinpelu, Nwando Mba, Rebecca Rosenke, Dana P. Scott, Greg Saturday, Chikwe Ihekweazu, David Safronetz

PLOS Pathogens: published October 11, 2021 | https://doi.org/10.1371/journal.ppat.1009966

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

Jaryd R. Sullivan, Andréanne Lupien, Elias Kalthoff, Claire Hamela, Lorne Taylor, Kim A. Munro, T. Martin Schmeing, Laurent Kremer, Marcel A. Behr

PLOS Pathogens: published October 12, 2021 | https://doi.org/10.1371/journal.ppat.1009965

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model

Kei Haga, Reiko Takai-Todaka, Yuta Matsumura, Chihong Song, Tomomi Takano, Takuto Tojo, Atsushi Nagami, Yuki Ishida, Hidekazu Masaki, Masayuki Tsuchiya, Toshiki Ebisudani, Shinya Sugimoto, Toshiro Sato, Hiroyuki Yasuda, Koichi Fukunaga, Akihito Sawada, Naoto Nemoto, Kazuyoshi Murata, Takuya Morimoto, Kazuhiko Katayama

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009542

Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase

Hiroki Sato, Miho Hoshi, Fusako Ikeda, Tomoko Fujiyuki, Misako Yoneda, Chieko Kai

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009841

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A. DeLaney, Opher S. Kornfeld, Bettina L. Lee, Eric M. Rodríguez López, Daniel Grubaugh, Meghan A. Wynosky-Dolfi, Naomi H. Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P. Beiting, Jorge Henao-Mejia, Brian C. Schaefer, Kaiwen W. Chen, Petr Broz, Igor E. Brodsky

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009967

Acquisition of yersinia murine toxin enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague

David M. Bland, Adélaïde Miarinjara, Christopher F. Bosio, Jeanette Calarco, B. Joseph Hinnebusch

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009995

Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants

André Volland, Michael Lohmüller, Emmanuel Heilmann, Janine Kimpel, Sebastian Herzog, Dorothee von Laer

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1009996

Specific interaction of an RNA-binding protein with the 3′-UTR of its target mRNA is critical to oomycete sexual reproduction

Hui Feng, Chuanxu Wan, Zhichao Zhang, Han Chen, Zhipeng Li, Haibin Jiang, Maozhu Yin, Suomeng Dong, Daolong Dou, Yuanchao Wang, Xiaobo Zheng, Wenwu Ye

PLOS Pathogens: published October 14, 2021 | https://doi.org/10.1371/journal.ppat.1010001

Essential role of M1 macrophages in blocking cytokine storm and pathology associated with murine HSV-1 infection

Ujjaldeep Jaggi, Harry H. Matundan, Jack Yu, Satoshi Hirose, Mathias Mueller, Floyd L. Wormley Jr, Homayon Ghiasi

PLOS Pathogens: published October 15, 2021 | https://doi.org/10.1371/journal.ppat.1009999

A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis

Hongwei Gu, Xuwang Cai, Xinyang Zhang, Jie Luo, Xiaoyang Zhang, Xiao Hu, Wentong Cai, Ganwu Li

PLOS Pathogens: published October 15, 2021 | https://doi.org/10.1371/journal.ppat.1010005

Hantaviruses use the endogenous host factor P58^IPK to combat the PKR antiviral response

Zekun Wang, Songyang Ren, Qiming Li, Austin D. Royster, Lei lin, Sichen Liu, Safder S. Ganaie, Jianming Qiu, Sheema Mir, Mohammad A. Mir

PLOS Pathogens: published October 15, 2021 | https://doi.org/10.1371/journal.ppat.1010007

Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis

Sarah G. Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M. Exley, Elisa Ramos-Sevillano, Douglas F. Browning, Vasiliki Kostiou, Odile B. Harrison, Holly B. Bratcher, Gabriele Varani, Christoph M. Tang, Daniel J. Wilson, Martin C. J. Maiden

PLOS Pathogens: published October 18, 2021 | https://doi.org/10.1371/journal.ppat.1009992

Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins

Hatim Thaker, Jie Zhang, Shin-Ichiro Miyashita, Vivian Cristofaro, SunHyun Park, Ali Hashemi Gheinani, Maryrose P. Sullivan, Rosalyn M. Adam, Min Dong

PLOS Pathogens: published October 18, 2021 | https://doi.org/10.1371/journal.ppat.1009994

Bile acid-independent protection against Clostridioides difficile infection

Andrea Martinez Aguirre, Nazli Yalcinkaya, Qinglong Wu, Alton Swennes, Mary Elizabeth Tessier, Paul Roberts, Fabio Miyajima, Tor Savidge, Joseph A. Sorg

PLOS Pathogens: published October 19, 2021 | https://doi.org/10.1371/journal.ppat.1010015

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

Basel H. Abuaita, Anna-Lisa E. Lawrence, Ryan P. Berger, David R. Hill, Sha Huang, Veda K. Yadagiri, Brooke Bons, Courtney Fields, Christiane E. Wobus, Jason R. Spence, Vincent B. Young, Mary X. O’Riordan

PLOS Pathogens: published October 20, 2021 | https://doi.org/10.1371/journal.ppat.1009987

Structure-guided antibody cocktail for prevention and treatment of COVID-19

Shih-Chieh Su, Tzu-Jing Yang, Pei-Yu Yu, Kang-Hao Liang, Wan-Yu Chen, Chun-Wei Yang, Hsiu-Ting Lin, Mei-Jung Wang, Ruei-Min Lu, Hsien-Cheng Tso, Meng-Jhe Chung, Tzung-Yang Hsieh, Yu-Ling Chang, Shin-Chang Lin, Fang-Yu Hsu, Feng-Yi Ke, Yi-Hsuan Wu, Yu-Chyi Hwang, I-Ju Liu, Jian-Jong Liang, Chun-Che Liao, Hui-Ying Ko, Cheng-Pu Sun, Ping-Yi Wu, Jia-Tsrong Jan, Yuan-Chih Chang, Yi-Ling Lin, Mi-Hua Tao, Shang-Te Danny Hsu, Han-Chung Wu

PLOS Pathogens: published October 21, 2021 | https://doi.org/10.1371/journal.ppat.1009704

Marek’s disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype

Laëtitia Trapp-Fragnet, Julia Schermuly, Marina Kohn, Luca D. Bertzbach, Florian Pfaff, Caroline Denesvre, Benedikt B. Kaufer, Sonja Härtle

PLOS Pathogens: published October 21, 2021 | https://doi.org/10.1371/journal.ppat.1010006

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

Kien Nguyen, Curtis Dobrowolski, Meenakshi Shukla, Won-Kyung Cho, Benjamin Luttge, Jonathan Karn

PLOS Pathogens: published October 21, 2021 | https://doi.org/10.1371/journal.ppat.1010014

Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

Emma T. Crooks, Francisco Almanza, Alessio D’Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D. Allen, Alyssa Thomas, Keiko Osawa, Bette T. Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K. Verkoczy, James M. Binley

PLOS Pathogens: published October 22, 2021 | https://doi.org/10.1371/journal.ppat.1009807

S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies

Dorota Kmiec, María José Lista, Mattia Ficarelli, Chad M. Swanson, Stuart J. D. Neil

PLOS Pathogens: published October 25, 2021 | https://doi.org/10.1371/journal.ppat.1009726

Induction of trained immunity by influenza vaccination - impact on COVID-19

Priya A. Debisarun, Katharina L. Gössling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Rüchel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A. C. M. Koeken, Jorge Domínguez-Andrés, Simone J. C. F. M. Moorlag, Esther Taks, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Jaap ten Oever, Reinout van Crevel, Yang Li, Mihai G. Netea

PLOS Pathogens: published October 25, 2021 | https://doi.org/10.1371/journal.ppat.1009928

A new paradigm for leprosy diagnosis based on host gene expression

Thyago Leal-Calvo, Charlotte Avanzi, Mayara Abud Mendes, Andrej Benjak, Philippe Busso, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Stewart Thomas Cole, Milton Ozório Moraes

PLOS Pathogens: published October 25, 2021 | https://doi.org/10.1371/journal.ppat.1009972

CD4⁺ T cell immunity to Salmonella is transient in the circulation

Newton G. Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M. Shreenivas, Ian Comerford, Dianna M. Hocking, Anna B. Erazo, Irmgard Förster, Andreas Kupz, Thomas Gebhardt, Shaun R. McColl, Stephen J. McSorley, Sammy Bedoui, Richard A. Strugnell

PLOS Pathogens: published October 25, 2021 | https://doi.org/10.1371/journal.ppat.1010004

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease

Soo Jin Park, Uram Jin, Sang Myun Park

PLOS Pathogens: published October 25, 2021 | https://doi.org/10.1371/journal.ppat.1010018

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx

Michaël M. Martin, Roy Matkovic, Pauline Larrous, Marina Morel, Angélique Lasserre, Virginie Vauthier, Florence Margottin-Goguet

PLOS Pathogens: published October 26, 2021 | https://doi.org/10.1371/journal.ppat.1009609

Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis

Tej Pratap Singh, Augusto M. Carvalho, Laís Amorim Sacramento, Elizabeth A. Grice, Phillip Scott

PLOS Pathogens: published October 26, 2021 | https://doi.org/10.1371/journal.ppat.1009693

Identification and characterization of short leader and trailer RNAs synthesized by the Ebola virus RNA polymerase

Simone Bach, Jana-Christin Demper, Paul Klemm, Julia Schlereth, Marcus Lechner, Andreas Schoen, Lennart Kämper, Friedemann Weber, Stephan Becker, Nadine Biedenkopf, Roland K. Hartmann

PLOS Pathogens: published October 26, 2021 | https://doi.org/10.1371/journal.ppat.1010002

Novel regulators of PrP^C biosynthesis revealed by genome-wide RNA interference

Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi

PLOS Pathogens: published October 27, 2021 | https://doi.org/10.1371/journal.ppat.1010013

Human albumin enhances the pathogenic potential of Candida glabrata on vaginal epithelial cells

Marina Pekmezovic, Ann-Kristin Kaune, Sophie Austermeier, Sophia U. J. Hitzler, Selene Mogavero, Hrant Hovhannisyan, Toni Gabaldón, Mark S. Gresnigt, Bernhard Hube

PLOS Pathogens: published October 28, 2021 | https://doi.org/10.1371/journal.ppat.1010037

Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma

Stacey L. Fanning, Robert Korngold, Zheng Yang, Kira Goldgirsh, Steven Park, Joshua Zenreich, Melissa Baker, Phyllis McKiernan, Ming Tan, Bingsong Zhang, Michele L. Donato, David S. Perlin

PLOS Pathogens: published October 29, 2021 | https://doi.org/10.1371/journal.ppat.1010025

Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways

Sophia C. Parks, Susan Nguyen, Shyon Nasrolahi, Chaitra Bhat, Damian Juncaj, Dihong Lu, Raghavendran Ramaswamy, Harpal Dhillon, Hideji Fujiwara, Anna Buchman, Omar S. Akbari, Naoki Yamanaka, Martin J. Boulanger, Adler R. Dillman

PLOS Pathogens: published October 29, 2021 | https://doi.org/10.1371/journal.ppat.1010027

Correction: Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans

The PLOS Pathogens Staff

PLOS Pathogens: published October 19, 2021 | https://doi.org/10.1371/journal.ppat.1010008

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1. Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans