Poxviruses, including smallpox and monkeypox, carry two proteinaceous structures called lateral bodies. During assembly, viral immunomodulatory proteins are packaged into these structures and subsequently released into newly infected cells during virus entry. Using this strategy, poxviruses begin to combat host cell defenses prior to initiating viral gene expression. Shown is a correlative STORM-TEM image of the poxvirus effector protein A19 (orange) residing within the lateral bodies of a mature vaccinia virus virion (grey). Bidgood et al 2022
Image Credit: Susanna Bidgood, Jemima Burden and David Albrecht.
Pearls
Bacterial secretion systems: Networks of pathogenic regulation and adaptation in mycobacteria and beyond
PLOS Pathogens: published July 14, 2022 | https://doi.org/10.1371/journal.ppat.1010610
Biodiversity is decimated by the cascading effects of the amphibian-killing chytrid fungus
PLOS Pathogens: published July 21, 2022 | https://doi.org/10.1371/journal.ppat.1010624
Evolving understanding of the type VII secretion system in Gram-positive bacteria
PLOS Pathogens: published July 28, 2022 | https://doi.org/10.1371/journal.ppat.1010680
Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond
PLOS Pathogens: published July 28, 2022 | https://doi.org/10.1371/journal.ppat.1010669
Reviews
Mycobacteriophages: From Petri dish to patient
PLOS Pathogens: published July 7, 2022 | https://doi.org/10.1371/journal.ppat.1010602
Emerging biology of noncoding RNAs in malaria parasites
PLOS Pathogens: published July 7, 2022 | https://doi.org/10.1371/journal.ppat.1010600
Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells
PLOS Pathogens: published July 14, 2022 | https://doi.org/10.1371/journal.ppat.1010608
Copper microenvironments in the human body define patterns of copper adaptation in pathogenic bacteria
PLOS Pathogens: published July 21, 2022 | https://doi.org/10.1371/journal.ppat.1010617
Assembly and transport of filovirus nucleocapsids
PLOS Pathogens: published July 28, 2022 | https://doi.org/10.1371/journal.ppat.1010616
Research Articles
STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling
PLOS Pathogens: published July 1, 2022 | https://doi.org/10.1371/journal.ppat.1010676
Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation
PLOS Pathogens: published July 1, 2022 | https://doi.org/10.1371/journal.ppat.1010647
Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile
PLOS Pathogens: published July 5, 2022 | https://doi.org/10.1371/journal.ppat.1010677
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species
PLOS Pathogens: published July 5, 2022 | https://doi.org/10.1371/journal.ppat.1010618
Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells
PLOS Pathogens: published July 5, 2022 | https://doi.org/10.1371/journal.ppat.1010673
A new adenine nucleotide transporter located in the ER is essential for maintaining the growth of Toxoplasma gondii
PLOS Pathogens: published July 5, 2022 | https://doi.org/10.1371/journal.ppat.1010665
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Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals
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Respiratory syncytial virus ribonucleoproteins hijack microtubule Rab11 dependent transport for intracellular trafficking
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Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells
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The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism
PLOS Pathogens: published July 8, 2022 | https://doi.org/10.1371/journal.ppat.1010623
A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity
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Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus
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Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae
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The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
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Correction
Correction: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
PLOS Pathogens: published July 7, 2022 | https://doi.org/10.1371/journal.ppat.1010699