Multistep Testing Algorithms for Clostridioides difficile Infection

Maribeth R Nicholson; Curtis J Donskey

doi:10.1001/jama.2023.15875

Multistep Testing Algorithms for Clostridioides difficile Infection

JAMA. 2023 Sep 12;330(10):966-967. doi: 10.1001/jama.2023.15875.

Authors

Maribeth R Nicholson¹, Curtis J Donskey²

Affiliations

¹ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee.
² Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio.

PMID: 37603324
PMCID: PMC10528531 (available on 2024-09-12)
DOI: 10.1001/jama.2023.15875

No abstract available

Plain language summary

A 10-year-old girl with spina bifida and neurogenic bowel hospitalized for abdominal pain, dehydration, and more than 20 episodes of diarrhea per day. A stool sample test result was positive for Clostridioides difficile by polymerase chain reaction and an enzyme immunoassay result for C difficile toxin A and B was negative. How do you interpret these test results?

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Clostridium Infections* / diagnosis
Diagnosis, Computer-Assisted* / methods
Humans

Grants and funding

K23 AI156132/AI/NIAID NIH HHS/United States