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Phase 2/3 Trial of Molnupiravir for Treatment of Covid-19 in Nonhospitalized Adults

NEJM Evid. 2022 Feb;1(2):EVIDoa2100043. doi: 10.1056/EVIDoa2100043. Epub 2021 Dec 16.

Abstract

Molnupiravir in Nonhospitalized Patients Molnupiravir induces viral mutations to a threshold beyond which Covid-19 cannot replicate. For nonhospitalized adults with mild-to-moderate Covid-19 symptoms before randomization, molnupiravir did not have dose-related effects on adverse events or laboratory results; 3.1% of patients were hospitalized or died compared with 5.4% treated with placebo.