Case-control study investigates changes in microcirculation and endothelial function in the acute phase of multisystem inflammatory syndrome in children and 3 to 6 months after onset. https://ja.ma/3T4PIiv
JAMA Pediatrics’ Post
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This fantastic study by Konings, et al. (2023) investigates potential associations between Parkinson’s and gastrointestinal (GI) disorders - hoping to indentify potential risk factors or early markers of PD. https://lnkd.in/g5y2kYnB Based on histologic findings of alpha-synuclein plaques (classically described in PD) in the enteric nervous system (ENS), Braak, et al. (2003) formed a hypothesis that Parkinson’s disease (PD) begins with formation of such plaques in the ENS - suggesting environmental exposures within the GI tract can influence one’s risk for PD. The thought is that such plaques could travel retrograde via the vagus nerve (and that vagotomy could even be protective!) to affect the central nervous system. This hypothesis has been investigated in prior smaller-scale studies. The authors of this paper found a clever way to minimize surveillance bias by comparing associations between the same GI disorders of interest and other neurodegenerative disorders (Alzheimer’s and cerebrovascular disease) while also drawing from very large samples. More studies need to be done to further investigate the identitified associations between PD and gastroparesis, intestinal pseudo-obstruction, and other GI disorders described. However this was quite an interesting and exciting read, and I really appreciated the thorough discussion of the methodology.
Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases
gut.bmj.com
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We are proud to see that the #research we have supported has brought about an important new perspective on the origin, modeling and treatment of #chronicdisease. In his latest publication Robert Naviaux expands on the previously proposed concept of Cell Danger Response (CDR) to include the concept of #salugenesis – the restorative healing process. "In contrast to acute illness, most cases of chronic diseases are not caused by an active threat. Instead, most symptoms of chronic disease result from incomplete healing and recovery after a threat or injury has passed. ...In some cases, chronic symptoms are caused by the inability to actively extinguish the metabolic program (metabolic memories) triggered by a past life-threatening exposure. In other cases, incomplete healing is caused by persistent local tissue danger signals, periodic reinjury, reinfection... ----- ...The development of a new class of medications and non-drug interventions designed to reboot, unblock, disinhibit, support, and promote the natural #biology of the healing cycle may one day facilitate recovery from chronic disorders that are currently incurable...." https://lnkd.in/eNVtKEqW #diseases #diabetes #autism #ptsd #recovery #cures #longcovid #mecfs
New Perspectives on Healing Chronic Diseases – a paper by Dr Naviaux
https://brainfoundation.org
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I'm happy to announce the publishing of our article " Navigating a Complex Presentation: Management of Hypernatremic Dehydration, Acute Kidney Injury, Hyperkalemia, and Metabolic Acidosis in a Patient With Down Syndrome: A Case Report "
Navigating a Complex Presentation: Management of Hypernatremic Dehydration, Acute Kidney Injury, Hyperkalemia, and Metabolic Acidosis in a Patient With Down Syndrome: A Case Report
cureus.com
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Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children https://lnkd.in/gGRrNvu5
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
science.org
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Parasite immunologist || Schistosomiasis || Sickle cell disease || Clonal hematopoiesis || Therapy-related myeloid malignancies
Interesting paper on the still unsolved mystery of the link between nodding syndrome/ epilepsy and onchocerciasis. https://lnkd.in/ef2JCRZu
Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns
journals.plos.org
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