Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO2 Nanoparticles
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials (Chemicals)
2.2. Methods for the Synthesis of Aqueous Sols of Cerium Dioxide, Including Those Doped with Gadolinium
2.3. Materials Characterisation
2.4. Preparation of Ceria-SOD Conjugates
2.5. Analysis of Enzyme-like Activity and Radical-Scavenging Properties
2.5.1. SOD-Mimetic Assay
2.5.2. Peroxidase Mimetic Assay
2.5.3. Analysis of Radical-Scavenging Properties
2.5.4. Statistical Analysis
3. Results and Discussion
3.1. Characterisation of CeO2 NPs and Gadolinium-Doped CeO2 NPs
3.2. Enzyme-like Activity and Radical-Scavenging Properties of CeO2 NPs and Gadolinium-Doped CeO2 NPs
3.2.1. SOD-Mimetic Activity
3.2.2. Peroxidase Mimetic Activity
3.2.3. Radical-Scavenging Properties (Antioxidant Activity)
3.3. Analysis of the Biological Activity of CeO2 and Gadolinium Doped (20%) CeO2 Sols, Including Sols Stabilized with Maltodextrin and Citrate Ions
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
- Li, D.; Fan, T.; Mei, X. A Comprehensive Exploration of the Latest Innovations for Advancements in Enhancing Selectivity and Efficiency of Nanozymes for Theranostic Nanoplatforms. Nanoscale 2023, 15, 15885–15905. [Google Scholar] [CrossRef] [PubMed]
- Singh, H.; Sareen, D.; George, J.M.; Bhardwaj, V.; Rha, S.; Lee, S.J.; Sharma, S.; Sharma, A.; Kim, J.S. Mitochondria targeted fluorogenic theranostic agents for cancer therapy. Coord. Chem. Rev. 2022, 452, 214283. [Google Scholar] [CrossRef]
- Muráth, S.; Szerlauth, A.; Sebők, D.; Szilágyi, I. Layered double hydroxide nanoparticles to overcome the hydrophobicity of ellagic acid: An antioxidant hybrid material. Antioxidants 2020, 9, 153. [Google Scholar] [CrossRef]
- Eriksson, P.; Tal, A.A.; Skallberg, A.; Brommesson, C.; Hu, Z.; Boyd, R.D.; Olovsson, W.; Fairley, N.; Abrikosov, I.A.; Zhang, X. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement. Sci. Rep. 2018, 8, 6999. [Google Scholar] [CrossRef] [PubMed]
- Marte, B. Tumour heterogeneity. Nature 2013, 501, 327. [Google Scholar] [CrossRef] [PubMed]
- Alizadeh, A.A.; Aranda, V.; Bardelli, A.; Blanpain, C.; Bock, C.; Borowski, C.; Caldas, C.; Califano, A.; Doherty, M.; Elsner, M. Toward understanding and exploiting tumor heterogeneity. Nat. Med. 2015, 21, 846–853. [Google Scholar] [CrossRef] [PubMed]
- Zhang, Y.; Jin, Y.; Cui, H.; Yan, X.; Fan, K. Nanozyme-based catalytic theranostics. RSC Adv. 2020, 10, 10–20. [Google Scholar] [CrossRef] [PubMed]
- Ali, A.; Ovais, M.; Zhou, H.; Rui, Y.; Chen, C. Tailoring metal-organic frameworks-based nanozymes for bacterial theranostics. Biomaterials 2021, 275, 120951. [Google Scholar] [CrossRef] [PubMed]
- Jiang, D.; Ni, D.; Rosenkrans, Z.T.; Huang, P.; Yan, X.; Cai, W. Nanozyme: New horizons for responsive biomedical applications. Chem. Soc. Rev. 2019, 48, 3683–3704. [Google Scholar] [CrossRef]
- Foulkes, R.; Man, E.; Thind, J.; Yeung, S.; Joy, A.; Hoskins, C. The regulation of nanomaterials and nanomedicines for clinical application: Current and future perspectives. Biomater. Sci. 2020, 8, 4653–4664. [Google Scholar] [CrossRef]
- Celardo, I.; Pedersen, J.Z.; Traversa, E.; Ghibelli, L. Pharmacological potential of cerium oxide nanoparticles. Nanoscale 2011, 3, 1411–1420. [Google Scholar] [CrossRef] [PubMed]
- Popov, A.L.; Shcherbakov, A.B.; Zholobak, N.; Baranchikov, A.Y.; Ivanov, V.K. Cerium dioxide nanoparticles as third-generation enzymes (nanozymes). Nanosyst. Phys. Chem. Math. 2017, 8, 760–781. [Google Scholar] [CrossRef]
- Shcherbakov, A.B.; Reukov, V.V.; Yakimansky, A.V.; Krasnopeeva, E.L.; Ivanova, O.S.; Popov, A.L.; Ivanov, V.K. CeO2 nanoparticle-containing polymers for biomedical applications: A review. Polymers 2021, 13, 924. [Google Scholar] [CrossRef]
- Korsvik, C.; Patil, S.; Seal, S.; Self, W.T. Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem. Commun. 2007, 1056–1058. [Google Scholar] [CrossRef] [PubMed]
- Heckert, E.G.; Karakoti, A.S.; Seal, S.; Self, W.T. The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials 2008, 29, 2705–2709. [Google Scholar] [CrossRef] [PubMed]
- Baldim, V.; Bedioui, F.; Mignet, N.; Margaill, I.; Berret, J.-F. The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration. Nanoscale 2018, 10, 6971–6980. [Google Scholar] [CrossRef] [PubMed]
- Sozarukova, M.M.; Shestakova, M.A.; Teplonogova, M.A.; Izmailov, D.Y.; Proskurnina, E.V.; Ivanov, V.K. Quantification of free radical scavenging properties and SOD-like activity of cerium dioxide nanoparticles in biochemical models. Russ. J. Inorg. Chem. 2020, 65, 597–605. [Google Scholar] [CrossRef]
- Singh, R.; Singh, S. Role of phosphate on stability and catalase mimetic activity of cerium oxide nanoparticles. Colloids Surf. B Biointerfaces 2015, 132, 78–84. [Google Scholar] [CrossRef]
- Pirmohamed, T.; Dowding, J.M.; Singh, S.; Wasserman, B.; Heckert, E.; Karakoti, A.S.; King, J.E.; Seal, S.; Self, W.T. Nanoceria exhibit redox state-dependent catalase mimetic activity. Chem. Commun. 2010, 46, 2736–2738. [Google Scholar] [CrossRef]
- Singh, R.; Singh, S. Redox-dependent catalase mimetic cerium oxide-based nanozyme protect human hepatic cells from 3-AT induced acatalasemia. Colloids Surf. B Biointerfaces 2019, 175, 625–635. [Google Scholar] [CrossRef]
- Jiao, X.; Song, H.; Zhao, H.; Bai, W.; Zhang, L.; Lv, Y. Well-redispersed ceria nanoparticles: Promising peroxidase mimetics for H2O2 and glucose detection. Anal. Methods 2012, 4, 3261–3267. [Google Scholar] [CrossRef]
- Ansari, A.A.; Solanki, P.R.; Malhotra, B. Hydrogen peroxide sensor based on horseradish peroxidase immobilized nanostructured cerium oxide film. J. Biotechnol. 2009, 142, 179–184. [Google Scholar] [CrossRef] [PubMed]
- Asati, A.; Santra, S.; Kaittanis, C.; Nath, S.; Perez, J.M. Oxidase-like activity of polymer-coated cerium oxide nanoparticles. Angew. Chem. 2009, 121, 2344–2348. [Google Scholar] [CrossRef] [PubMed]
- Asati, A.; Kaittanis, C.; Santra, S.; Perez, J.M. pH-tunable oxidase-like activity of cerium oxide nanoparticles achieving sensitive fluorigenic detection of cancer biomarkers at neutral pH. Anal. Chem. 2011, 83, 2547–2553. [Google Scholar] [CrossRef] [PubMed]
- Liu, B.; Huang, Z.; Liu, J. Boosting the oxidase mimicking activity of nanoceria by fluoride capping: Rivaling protein enzymes and ultrasensitive F− detection. Nanoscale 2016, 8, 13562–13567. [Google Scholar] [CrossRef] [PubMed]
- Tian, Z.; Yao, T.; Qu, C.; Zhang, S.; Li, X.; Qu, Y. Photolyase-like catalytic behavior of CeO2. Nano Lett. 2019, 19, 8270–8277. [Google Scholar] [CrossRef] [PubMed]
- Khulbe, K.; Karmakar, K.; Ghosh, S.; Chandra, K.; Chakravortty, D.; Mugesh, G. Nanoceria-based phospholipase-mimetic cell membrane disruptive antibiofilm agents. ACS Appl. Bio Mater. 2020, 3, 4316–4328. [Google Scholar] [CrossRef]
- Xu, F.; Lu, Q.; Huang, P.-J.J.; Liu, J. Nanoceria as a DNase I mimicking nanozyme. Chem. Commun. 2019, 55, 13215–13218. [Google Scholar] [CrossRef]
- Bhalkikar, A.; Wu, T.-S.; Fisher, T.J.; Sarella, A.; Zhang, D.; Gao, Y.; Soo, Y.-L.; Cheung, C.L. Tunable catalytic activity of gadolinium-doped ceria nanoparticles for pro-oxidation of hydrogen peroxide. Nano Res. 2020, 13, 2384–2392. [Google Scholar] [CrossRef]
- Sozarukova, M.M.; Proskurnina, E.V.; Popov, A.L.; Kalinkin, A.L.; Ivanov, V.K. New facets of nanozyme activity of ceria: Lipo- and phospholipoperoxidase-like behaviour of CeO2 nanoparticles. RSC Adv. 2021, 11, 35351–35360. [Google Scholar] [CrossRef]
- Liu, D.; Yang, P.; Wang, F.; Wang, C.; Chen, L.; Ye, S.; Dramou, P.; Chen, J.; He, H. Study on performance of mimic uricase and its application in enzyme-free analysis. Anal. Bioanal. Chem. 2021, 413, 6571–6580. [Google Scholar] [CrossRef]
- Alpaslan, E.; Yazici, H.; Golshan, N.H.; Ziemer, K.S.; Webster, T.J. pH-dependent activity of dextran-coated cerium oxide nanoparticles on prohibiting osteosarcoma cell proliferation. ACS Biomater. Sci. Eng. 2015, 1, 1096–1103. [Google Scholar] [CrossRef] [PubMed]
- Shi, X.; Yang, J.; Wen, X.; Tian, F.; Li, C. Oxygen vacancy enhanced biomimetic superoxide dismutase activity of CeO2-Gd nanozymes. J. Rare Earths 2021, 39, 1108–1116. [Google Scholar] [CrossRef]
- Li, C.; Shi, X.; Bao, L.; Yang, J.; Damirin, A.; Zhang, J. The correlation between multiple variable factors and the autocatalytic properties of cerium oxide nanoparticles based on cell viability. New J. Chem. 2018, 42, 9975–9986. [Google Scholar] [CrossRef]
- Neal, C.J.; Kolanthai, E.; Wei, F.; Coathup, M.; Seal, S. Surface Chemistry of Biologically-Active Reducible Oxide Nanozymes. Adv. Mater. 2023, 36, 2211261. [Google Scholar] [CrossRef] [PubMed]
- Kumar, A.; Devanathan, R.; Shutthanandan, V.; Kuchibhatla, S.; Karakoti, A.; Yong, Y.; Thevuthasan, S.; Seal, S. Radiation-induced reduction of ceria in single and polycrystalline thin films. J. Phys. Chem. C 2012, 116, 361–366. [Google Scholar] [CrossRef]
- Wu, Y.; Xu, W.; Jiao, L.; Tang, Y.; Chen, Y.; Gu, W.; Zhu, C. Defect engineering in nanozymes. Mater. Today 2022, 52, 327–347. [Google Scholar] [CrossRef]
- Wei, Z.; Wu, M.; Li, Z.; Lin, Z.; Zeng, J.; Sun, H.; Liu, X.; Liu, J.; Li, B.; Zeng, Y. Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle. Drug Deliv. 2018, 25, 353–363. [Google Scholar] [CrossRef] [PubMed]
- Li, J.; Yao, S.; Song, S.; Wang, X.; Wang, Y.; Ding, X.; Wang, F.; Zhang, H. Designed synthesis of multi-functional PEGylated Yb2O3: Gd@SiO2@CeO2 islands core@shell nanostructure. Dalton Trans. 2016, 45, 11522–11527. [Google Scholar] [CrossRef]
- Vinothkumar, G.; Rengaraj, S.; Arunkumar, P.; Cha, S.W.; Suresh Babu, K. Ionic radii and concentration dependency of RE3+ (Eu3+, Nd3+, Pr3+, and La3+)-doped cerium oxide nanoparticles for enhanced multienzyme-mimetic and hydroxyl radical scavenging activity. J. Phys. Chem. C 2018, 123, 541–553. [Google Scholar] [CrossRef]
- Ackermann, S.; Sauvin, L.; Castiglioni, R.; Rupp, J.L.; Scheffe, J.R.; Steinfeld, A. Kinetics of CO2 reduction over nonstoichiometric ceria. J. Phys. Chem. C 2015, 119, 16452–16461. [Google Scholar] [CrossRef] [PubMed]
- Babu, S.; Thanneeru, R.; Inerbaev, T.; Day, R.; Masunov, A.E.; Schulte, A.; Seal, S. Dopant-mediated oxygen vacancy tuning in ceria nanoparticles. Nanotechnology 2009, 20, 085713. [Google Scholar] [CrossRef] [PubMed]
- Gupta, A.; Das, S.; Neal, C.J.; Seal, S. Controlling the surface chemistry of cerium oxide nanoparticles for biological applications. J. Mater. Chem. B 2016, 4, 3195–3202. [Google Scholar] [CrossRef] [PubMed]
- Todd, D.J.; Kay, J. Nephrogenic systemic fibrosis: An epidemic of gadolinium toxicity. Curr. Rheumatol. Rep. 2008, 10, 195–204. [Google Scholar] [CrossRef]
- Rogosnitzky, M.; Branch, S. Gadolinium-based contrast agent toxicity: A review of known and proposed mechanisms. Biometals 2016, 29, 365–376. [Google Scholar] [CrossRef]
- Söderlind, F.; Pedersen, H.; Petoral, R.M., Jr.; Käll, P.-O.; Uvdal, K. Synthesis and characterisation of Gd2O3 nanocrystals functionalised by organic acids. J. Colloid Interface Sci. 2005, 288, 140–148. [Google Scholar] [CrossRef] [PubMed]
- Ahrén, M.; Selegård, L.; Söderlind, F.; Linares, M.; Kauczor, J.; Norman, P.; Käll, P.-O.; Uvdal, K. A simple polyol-free synthesis route to Gd2O3 nanoparticles for MRI applications: An experimental and theoretical study. J. Nanoparticle Res. 2012, 14, 1006. [Google Scholar] [CrossRef]
- Ahrén, M.; Selegård, L.; Klasson, A.; Soderlind, F.; Abrikossova, N.; Skoglund, C.; Bengtsson, T.; Engström, M.; Käll, P.O.; Uvdal, K. Synthesis and characterization of PEGylated Gd2O3 nanoparticles for MRI contrast enhancement. Langmuir 2010, 26, 5753–5762. [Google Scholar] [CrossRef]
- Hu, Z.; Ahrén, M.; Selegård, L.; Skoglund, C.; Söderlind, F.; Engström, M.; Zhang, X.; Uvdal, K. Highly Water-Dispersible Surface-Modified Gd2O3 Nanoparticles for Potential Dual-Modal Bioimaging. Chem. Eur. J. 2013, 19, 12658–12667. [Google Scholar] [CrossRef]
- Nune, S.K.; Gunda, P.; Thallapally, P.K.; Lin, Y.-Y.; Laird Forrest, M.; Berkland, C.J. Nanoparticles for biomedical imaging. Expert Opin. Drug Deliv. 2009, 6, 1175–1194. [Google Scholar] [CrossRef]
- Sharma, P.; Brown, S.; Walter, G.; Santra, S.; Moudgil, B. Nanoparticles for bioimaging. Adv. Colloid Interface Sci. 2006, 123, 471–485. [Google Scholar] [CrossRef] [PubMed]
- Popov, A.; Abakumov, M.; Savintseva, I.; Ermakov, A.; Popova, N.; Ivanova, O.; Kolmanovich, D.; Baranchikov, A.; Ivanov, V. Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells. J. Mater. Chem. B 2021, 9, 6586–6599. [Google Scholar] [CrossRef] [PubMed]
- Gasymova, G.A.; Ivanova, O.S.; Baranchikov, A.Y.; Shcherbakov, A.B.; Ivanov, V.K.; Tret’yakov, Y.D. Synthesis of aqueous sols of nanocrystalline ceria doped with gadolinia. Nanosyst. Phys. Chem. Math. 2011, 2, 113–120. [Google Scholar]
- Gil, D.; Rodriguez, J.; Ward, B.; Vertegel, A.; Ivanov, V.; Reukov, V. Antioxidant activity of SOD and catalase conjugated with nanocrystalline ceria. Bioengineering 2017, 4, 18. [Google Scholar] [CrossRef]
- Sozarukova, M.M.; Proskurnina, E.V.; Baranchikov, A.E.; Ivanov, V.K. CeO2 nanoparticles as free radical regulators in biological systems. Nanosyst. Phys. Chem. Math. 2020, 11, 324–332. [Google Scholar] [CrossRef]
- Fridovich, I. Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J. Biol. Chem. 1970, 245, 4053–4057. [Google Scholar] [CrossRef] [PubMed]
- Ichibangase, T.; Ohba, Y.; Kishikawa, N.; Nakashima, K.; Kuroda, N. Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2O2. Luminescence 2014, 29, 118–121. [Google Scholar] [CrossRef] [PubMed]
- Zhang, W.; Hao, L.; Huang, J.; Xia, L.; Cui, M.; Zhang, X.; Gu, Y.; Wang, P. Chemiluminescence chitosan hydrogels based on the luminol analog L-012 for highly sensitive detection of ROS. Talanta 2019, 201, 455–459. [Google Scholar] [CrossRef] [PubMed]
- Filippova, A.D.; Sozarukova, M.M.; Baranchikov, A.E.; Kottsov, S.Y.; Cherednichenko, K.A.; Ivanov, V.K. Peroxidase-like Activity of CeO2 Nanozymes: Particle Size and Chemical Environment Matter. Molecules 2023, 28, 3811. [Google Scholar] [CrossRef]
- Alekseev, A.V.; Proskurnina, E.V.; Vladimirov, Y.A. Determination of antioxidants by sensitized chemiluminescence using 2, 2′-azo-bis (2-amidinopropane). Mosc. Univ. Chem. Bull. 2012, 67, 127–132. [Google Scholar] [CrossRef]
- Yin, L.; Wang, Y.; Pang, G.; Koltypin, Y.; Gedanken, A. Sonochemical synthesis of cerium oxide nanoparticles—Effect of additives and quantum size effect. J. Colloid Interface Sci. 2002, 246, 78–84. [Google Scholar] [CrossRef] [PubMed]
- Gao, Y.; Liu, S.; Zeng, X.; Guo, Z.; Chen, D.; Li, S.; Tian, Z.; Qu, Y. Reduction of Reactive Oxygen Species Accumulation Using Gadolinium-Doped Ceria for the Alleviation of Atherosclerosis. ACS Appl. Mater. Interfaces 2023, 15, 10414–10425. [Google Scholar] [CrossRef] [PubMed]
- Li, J.G.; Ikegami, T.; Wang, Y.; Mori, T. 10-mol%-Gd2O3-Doped CeO2 solid solutions via carbonate coprecipitation: A comparative study. J. Am. Ceram. Soc. 2003, 86, 915–921. [Google Scholar] [CrossRef]
- Mehmood, R.; Ariotti, N.; Yang, J.L.; Koshy, P.; Sorrell, C.C. pH-responsive morphology-controlled redox behavior and cellular uptake of nanoceria in fibrosarcoma. ACS Biomater. Sci. Eng. 2018, 4, 1064–1072. [Google Scholar] [CrossRef] [PubMed]
- Dong, S.; Dong, Y.; Liu, B.; Liu, J.; Liu, S.; Zhao, Z.; Li, W.; Tian, B.; Zhao, R.; He, F. Guiding Transition Metal-Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi-Enzymatic Activities for Intensive Chemodynamic Therapy. J. Adv. Mater. 2022, 34, 2107054. [Google Scholar] [CrossRef]
- Kainbayev, N.; Sriubas, M.; Virbukas, D.; Rutkuniene, Z.; Bockute, K.; Bolegenova, S.; Laukaitis, G. Raman study of nanocrystalline-doped ceria oxide thin films. Coatings 2020, 10, 432. [Google Scholar] [CrossRef]
- Nayak, P.; Santhosh, P.; Ramaprabhu, S. Cerium oxide nanoparticles decorated graphene nanosheets for selective detection of dopamine. J. Nanosci. Nanotechnol. 2015, 15, 4855–4862. [Google Scholar] [CrossRef] [PubMed]
- Durgasri, D.N.; Vinodkumar, T.; Sudarsanam, P.; Reddy, B.M. Nanosized CeO2-Gd2O3 mixed oxides: Study of structural characterization and catalytic CO oxidation activity. Catal. Lett. 2014, 144, 971–979. [Google Scholar] [CrossRef]
- Ivanov, V.K.; Shcherbakov, A.B.; Usatenko, A.V. Structure-sensitive properties and biomedical applications of nanodispersed cerium dioxide. Russ. Chem. Rev. 2009, 78, 855. [Google Scholar] [CrossRef]
- Wang, Z.; Zeng, Y.; Li, C.; Ye, Z.; Cao, L.; Zhang, Y. Structures and electrical conductivities of Gd3+ and Fe3+ co-doped cerium oxide electrolytes sintered at low temperature for ILT-SOFCs. Ceram. Int. 2018, 44, 10328–10334. [Google Scholar] [CrossRef]
- Chaudhary, Y.S.; Panigrahi, S.; Nayak, S.; Satpati, B.; Bhattacharjee, S.; Kulkarni, N. Facile synthesis of ultra-small monodisperse ceria nanocrystals at room temperature and their catalytic activity under visible light. J. Mater. Chem. 2010, 20, 2381–2385. [Google Scholar] [CrossRef]
- Dunnick, K.M.; Pillai, R.; Pisane, K.L.; Stefaniak, A.B.; Sabolsky, E.M.; Leonard, S.S. The effect of cerium oxide nanoparticle valence state on reactive oxygen species and toxicity. Biol. Trace Elem. Res. 2015, 166, 96–107. [Google Scholar] [CrossRef] [PubMed]
- Afanas’ev, I.B. Lucigenin chemiluminescence assay for superoxide detection. Circ. Res. 2001, 89, e46. [Google Scholar] [CrossRef] [PubMed]
- Galbusera, C.; Orth, P.; Fedida, D.; Spector, T. Superoxide radical production by allopurinol and xanthine oxidase. Biochem. Pharmacol. 2006, 71, 1747–1752. [Google Scholar] [CrossRef] [PubMed]
- Liochev, S.I.; Fridovich, I. Lucigenin as mediator of superoxide production: Revisited. Free Radic. Biol. Med. 1998, 25, 926–928. [Google Scholar] [CrossRef] [PubMed]
- Perez, J.M.; Asati, A.; Nath, S.; Kaittanis, C. Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties. Small 2008, 4, 552–555. [Google Scholar] [CrossRef] [PubMed]
- Shcherbakov, A.B.; Teplonogova, M.A.; Ivanova, O.S.; Shekunova, T.O.; Ivonin, I.V.; Baranchikov, A.Y.; Ivanov, V.K. Facile method for fabrication of surfactant-free concentrated CeO2 sols. Mater. Res. Express 2017, 4, 055008. [Google Scholar] [CrossRef]
- Li, Y.; He, X.; Yin, J.J.; Ma, Y.; Zhang, P.; Li, J.; Ding, Y.; Zhang, J.; Zhao, Y.; Chai, Z. Acquired superoxide-scavenging ability of ceria nanoparticles. Angew. Chem. 2015, 127, 1852–1855. [Google Scholar] [CrossRef] [PubMed]
- Khadar, Y.S.; Balamurugan, A.; Devarajan, V.; Subramanian, R. Hydrothermal synthesis of gadolinium (Gd) doped cerium oxide (CeO2) nanoparticles: Characterization and antibacterial activity. Orient. J. Chem. 2017, 33, 2405. [Google Scholar] [CrossRef]
- Weng, Q.; Sun, H.; Fang, C.; Xia, F.; Liao, H.; Lee, J.; Wang, J.; Xie, A.; Ren, J.; Guo, X. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics. Nat. Commun. 2021, 12, 1436. [Google Scholar] [CrossRef]
- Soh, M.; Kang, D.W.; Jeong, H.G.; Kim, D.; Kim, D.Y.; Yang, W.; Song, C.; Baik, S.; Choi, I.Y.; Ki, S.K. Ceria-Zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment. Angew. Chem. 2017, 129, 11557–11561. [Google Scholar] [CrossRef] [PubMed]
- Tian, Z.; Li, X.; Ma, Y.; Chen, T.; Xu, D.; Wang, B.; Qu, Y.; Gao, Y. Quantitatively intrinsic biomimetic catalytic activity of nanocerias as radical scavengers and their ability against H2O2 and doxorubicin-induced oxidative stress. ACS Appl. Mater. Interfaces 2017, 9, 23342–23352. [Google Scholar] [CrossRef] [PubMed]
- Babior, B.; Lambeth, J.; Nauseef, W. The neutrophil NADPH oxidase. Arch. Biochem. Biophys. 2002, 397, 342–344. [Google Scholar] [CrossRef] [PubMed]
- Baranchikov, A.E.; Sozarukova, M.M.; Mikheev, I.V.; Egorova, A.A.; Proskurnina, E.V.; Poimenova, I.A.; Krasnova, S.A.; Filippova, A.D.; Ivanov, V.K. Biocompatible ligands modulate nanozyme activity of CeO2 nanoparticles. New J. Chem. 2023, 47, 20388–20404. [Google Scholar] [CrossRef]
- Zuo, L.; Christofi, F.L.; Wright, V.P.; Bao, S.; Clanton, T.L. Lipoxygenase-dependent superoxide release in skeletal muscle. J. Appl. Physiol. 2004, 97, 661–668. [Google Scholar] [CrossRef] [PubMed]
- Tarnuzzer, R.W.; Colon, J.; Patil, S.; Seal, S. Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage. Nano Lett. 2005, 5, 2573–2577. [Google Scholar] [CrossRef] [PubMed]
- Karakoti, A.S.; Singh, S.; Kumar, A.; Malinska, M.; Kuchibhatla, S.V.; Wozniak, K.; Self, W.T.; Seal, S. PEGylated nanoceria as radical scavenger with tunable redox chemistry. J. Am. Chem. Soc. 2009, 131, 14144–14145. [Google Scholar] [CrossRef]
- Wu, H.; Li, F.; Wang, S.; Lu, J.; Li, J.; Du, Y.; Sun, X.; Chen, X.; Gao, J.; Ling, D. Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing. Biomaterials 2018, 151, 66–77. [Google Scholar] [CrossRef]
- Chen, B.-H.; Stephen Inbaraj, B. Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles. Crit. Rev. Biotechnol. 2018, 38, 1003–1024. [Google Scholar] [CrossRef]
- Wei, F.; Neal, C.J.; Sakthivel, T.S.; Kean, T.; Seal, S.; Coathup, M.J. Multi-functional cerium oxide nanoparticles regulate inflammation and enhance osteogenesis. Mater. Sci. Eng. C 2021, 124, 112041. [Google Scholar] [CrossRef]
- Ghosalya, M.K.; Li, X.; Beck, A.; van Bokhoven, J.A.; Artiglia, L. Size of ceria particles influences surface hydroxylation and hydroxyl stability. J. Phys. Chem. C 2021, 125, 9303–9309. [Google Scholar] [CrossRef]
- Cafun, J.-D.; Kvashnina, K.O.; Casals, E.; Puntes, V.F.; Glatzel, P. Absence of Ce3+ sites in chemically active colloidal ceria nanoparticles. ACS Nano 2013, 7, 10726–10732. [Google Scholar] [CrossRef] [PubMed]
- Yang, Y.; Mao, Z.; Huang, W.; Liu, L.; Li, J.; Li, J.; Wu, Q. Redox enzyme-mimicking activities of CeO2 nanostructures: Intrinsic influence of exposed facets. Sci. Rep. 2016, 6, 35344. [Google Scholar] [CrossRef] [PubMed]
- Robert, A.; Meunier, B. How to define a nanozyme. ACS Nano 2022, 16, 6956–6959. [Google Scholar] [CrossRef]
- Zandieh, M.; Liu, J. Nanozymes: Definition, activity, and mechanisms. Adv. Mater. 2023, 36, 2211041. [Google Scholar] [CrossRef] [PubMed]
- Vladimirov, G.; Sergunova, E.; Izmaylov, D.; Vladimirov, Y. Chemiluminescent determination of total antioxidant capacity in medicinal plant material. Bull. Russ. State Med. Univ. 2016, 2016, 62–68. [Google Scholar] [CrossRef]
- Garcia-Salvador, A.; Katsumiti, A.; Rojas, E.; Aristimuno, C.; Betanzos, M.; Martinez-Moro, M.; Moya, S.E.; Goni-de-Cerio, F. A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study. Nanomaterials 2021, 11, 1577. [Google Scholar] [CrossRef] [PubMed]
- Inbaraj, B.S.; Chen, B.-H. An overview on recent in vivo biological application of cerium oxide nanoparticles. Asian J. Pharm. Sci. 2020, 15, 558–575. [Google Scholar] [CrossRef]
- Datta, A.; Mishra, S.; Manna, K.; Saha, K.D.; Mukherjee, S.; Roy, S. Pro-oxidant therapeutic activities of cerium oxide nanoparticles in colorectal carcinoma cells. ACS Omega 2020, 5, 9714–9723. [Google Scholar] [CrossRef]
Sample | k1 (μM/min) | k2 (μM/min) | k3 (μM/min) | k4 (μM/min) |
---|---|---|---|---|
bare CeO2 NPs | 3.0 × 10−14 | 3.5 × 109 | 9.0 × 1011 | 9.8 × 10−8 |
CeO2:Gd NPs (10%) | 9.2 × 10−14 | 8.7 × 109 | 3.8 × 1011 | 3.9 × 10−8 |
CeO2:Gd NPs (20%) | 9.0 × 10−14 | 9.5 × 109 | 4.0 × 1011 | 2.6 × 10−8 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Sozarukova, M.M.; Kozlova, T.O.; Beshkareva, T.S.; Popov, A.L.; Kolmanovich, D.D.; Vinnik, D.A.; Ivanova, O.S.; Lukashin, A.V.; Baranchikov, A.E.; Ivanov, V.K. Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO2 Nanoparticles. Nanomaterials 2024, 14, 769. https://doi.org/10.3390/nano14090769
Sozarukova MM, Kozlova TO, Beshkareva TS, Popov AL, Kolmanovich DD, Vinnik DA, Ivanova OS, Lukashin AV, Baranchikov AE, Ivanov VK. Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO2 Nanoparticles. Nanomaterials. 2024; 14(9):769. https://doi.org/10.3390/nano14090769
Chicago/Turabian StyleSozarukova, Madina M., Taisiya O. Kozlova, Tatiana S. Beshkareva, Anton L. Popov, Danil D. Kolmanovich, Darya A. Vinnik, Olga S. Ivanova, Alexey V. Lukashin, Alexander E. Baranchikov, and Vladimir K. Ivanov. 2024. "Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO2 Nanoparticles" Nanomaterials 14, no. 9: 769. https://doi.org/10.3390/nano14090769