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Challenges and future directions for studying effects of host genetics on the gut microbiome.

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Affiliations

  • 1. Institute for Genetic and Biomedical Research (IRGB), National Research Council (CNR), Monserrato, Cagliari, Italy.
      Authors
    • Sanna S 1, 2
    (1 author)
  • 2. Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
      Authors
    • Sanna S 1, 2
    • Kurilshikov A 2
    • van der Graaf A 2
    • Fu J 2
    • Zhernakova A 2
    (5 authors)

ORCIDs linked to this article

Nature Genetics, 03 Feb 2022, 54(2):100-106
https://doi.org/10.1038/s41588-021-00983-z PMID: 35115688 

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Abstract 

The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome.

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Read article at publisher's site: https://doi.org/10.1038/s41588-021-00983-z

Read article for free, from open access legal sources, via Unpaywall: https://pure.rug.nl/ws/files/202784194/Challenges_and_future_directions_for_studying_effects_of_host_genetics_on_the_gut_microbiome.pdfUnpaywall

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    Funding 

    Funders who supported this work.

    CVON: Netherland Cardiovascular Research Initiative

      Dutch Research Council (NWO) (3)