Decoding the patterns of self and nonself by the innate immune system.

Medzhitov R; Janeway CA Jr

doi:10.1126/science.1068883

Decoding the patterns of self and nonself by the innate immune system.

Medzhitov R ¹,

Janeway CA Jr

Affiliations

1. Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Authors
Medzhitov R¹
(1 author)

Science, 01 Apr 2002, 296(5566):298-300
https://doi.org/10.1126/science.1068883 PMID: 11951031

Abstract

The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.

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Decoding the patterns of self and nonself by the innate immune system.

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Global warming-related response after bacterial challenge in Astroides calycularis, a Mediterranean thermophilic coral.

Neutrophil Extracellular DNA Traps in Response to Infection or Inflammation, and the Roles of Platelet Interactions.

B Cells Dynamic in Aging and the Implications of Nutritional Regulation.

Biofilms in Periprosthetic Orthopedic Infections Seen through the Eyes of Neutrophils: How Can We Help Neutrophils?

Targeting tumor-associated macrophage: an adjuvant strategy for lung cancer therapy.

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Decoding the patterns of self and nonself by the innate immune system.

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