Early liaisons between cells of the innate immune system in inflamed peripheral tissues.

Moretta A; Marcenaro E; Sivori S; Della Chiesa M; Vitale M; Moretta L

doi:10.1016/j.it.2005.09.008

Abstract

The crosstalk between natural killer (NK) cells and myeloid dendritic cells (DCs) results in NK-cell activation and DC maturation. Activated NK cells acquire the ability to kill DCs that have failed to undergo complete maturation ('DC editing'). Recent studies have revealed that this crosstalk can be promoted by pathogen-derived products that activate different innate immune cell types directly and simultaneously through their Toll-like receptors (TLRs). These cells include NK cells and DCs, as well as plasmacytoid DCs (PDCs) and mast cells. This crosstalk can have a great impact on the quality and strength of the subsequent adaptive immune response. Thus, NK cells have an important role in the defense against pathogens, acting as regulatory cells as well as effector cells.

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Early liaisons between cells of the innate immune system in inflamed peripheral tissues.

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References

Receptors for HLA class-I molecules in human natural killer cells.

Regulation of immune responses through inhibitory receptors.

NK cell recognition of non-classical HLA class I molecules.

KIR: diverse, rapidly evolving receptors of innate and adaptive immunity.

Cellular ligands of activating NK receptors.

Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

Natural killer cell signaling pathways.

Ligands for natural killer cell receptors: redundancy or specificity.

Roles of the NKG2D immunoreceptor and its ligands.

Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.it.2005.09.008

Article citations

Immuno-Diagnostic Interest in Monitoring CD16+CD56+ (Natural Killer) Cells and CD19+CD45+ (B Lymphocytes) in Individuals Newly Diagnosed with HIV in a Tertiary Care Center.

Murine models to study human NK cells in human solid tumors.

Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease.

Assessment of the risk of unexplained recurrent spontaneous abortion based on the proportion and correlation of NK cells and T cells in peripheral blood.

The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function: An Overview.

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