Approaching the asymptote: 20 years later.

Medzhitov R

doi:10.1016/j.immuni.2009.06.004

Abstract

The pattern recognition theory proposed by the late Charles Janeway, Jr. 20 years ago provided a conceptual framework for our current understanding of the innate immune recognition and its role in the activation of adaptive immunity. Discovery of several families of pattern recognition receptors and their roles in mammalian immunity provided experimental support for the Janeway's theory. In addition to pattern recognition, there are other forms of innate immune sensing, which presumably work in specific combinations depending on the pathogen class and the type of the immune response they elicit. Here, the development of the Janeway's theory is discussed in the context of the advances made in field of innate immune recognition over the past two decades.

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Approaching the asymptote: 20 years later.

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References

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.

Actively acquired tolerance of foreign cells.

Pentraxins as a key component of innate immunity.

A theory of self-nonself discrimination.

Immune recognition. A new receptor for beta-glucans.

Title not supplied

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

Effect of meningococcal endotoxin on the immune response.

Citations & impact

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Citations of article over time

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Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.immuni.2009.06.004

Article citations

The Host Response to Coccidioidomycosis.

Orange-spotted grouper nervous necrosis virus-encoded protein A induces interferon expression via RIG-I/MDA5-MAVS-TBK1-IRF3 signaling in fish cells.

Innate immunity decreases pathogen diversity during infection.

cFLIP_S regulates alternative NLRP3 inflammasome activation in human monocytes.

Transcriptional and proteomic analysis of the innate immune response to microbial stimuli in a model invertebrate chordate.

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Wikipedia

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Howard Hughes Medical Institute

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Approaching the asymptote: 20 years later.

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