BBC Russian
Svoboda | Graniru | BBC Russia | Golosameriki | Facebook

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Toll-like receptor signaling in uterine natural killer cells--role in embryonic loss.

Author information

Affiliations

  • 1. Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
      Authors
    • Lin Y 1
    (1 author)

Journal of Reproductive Immunology, 03 Nov 2009, 83(1-2):95-100
https://doi.org/10.1016/j.jri.2009.09.004 PMID: 19889464 

Review

Abstract 

Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16(-)CD56(bright) NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3(-)CD49b(+)CD25(+)Foxp3(+) phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3(-)CD49b(+)CD25(+)Foxp3(+) cells and CXCR4 expression on CD16(-)CD56(bright) NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.jri.2009.09.004

References 

Articles referenced by this article (47)

Show 10 more references (10 of 47)

Citations & impact 

Impact metrics

7
Citations
Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.jri.2009.09.004

Supporting
Mentioning
Contrasting
0
10
0

Article citations

Go to all (7) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

Ministry of Education, Culture, Sports, Science and Technology (3)

Ministry of Health, Labour and Welfare

    National Key Research and Development Program of China (1)

    National Natural Science Foundation of China (3)