Monocyte and macrophage heterogeneity and Toll-like receptors in the lung.

Schneberger D; Aharonson-Raz K; Singh B

doi:10.1007/s00441-010-1032-2

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung.

Schneberger D ¹,

Aharonson-Raz K ,

Singh B

Affiliations

1. Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.
Authors
Schneberger D¹
(1 author)

ORCIDs linked to this article

Cell and Tissue Research, 08 Sep 2010, 343(1):97-106
https://doi.org/10.1007/s00441-010-1032-2 PMID: 20824285

Review

Abstract

Mononuclear phagocytes are crucial components of the innate host defense system. Cells such as macrophages and monocytes phagocytose and process pathogens, produce inflammatory mediators, and link the innate and the adaptive immune systems. The role of innate immune receptors such as Toll-like receptors (TLRs) in the recognition of pathogens is critical for mounting a precise and targeted immune response. This review focuses attention on the development of monocytes and macrophages, various populations of macrophages, and the expression and function of TLRs on macrophages.

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References

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Search life-sciences literature (44,004,653 articles, preprints and more)

Monocyte and macrophage heterogeneity and Toll-like receptors in the lung.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Pulmonary intravascular macrophages and endotoxin-induced pulmonary pathophysiology in horses.

Toll-like receptors: critical proteins linking innate and acquired immunity.

Expression of toll-like receptor 2 (TLR2) in porcine leukocyte subsets and tissues.

Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways.

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.

Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.

Regulation of phagosome maturation by signals from toll-like receptors.

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.

Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

The alveolar macrophage.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives.

Expression of pentraxin 3 in equine lungs and neutrophils.

Plasticity towards Rigidity: A Macrophage Conundrum in Pulmonary Fibrosis.

Flow Cytometric Analysis of Leukocyte Populations in the Lung Tissue of Dromedary Camels.

Differential susceptibility to lipopolysaccharide affects the activation of toll-like-receptor 4 signaling in THP-1 cells and PMA-differentiated THP-1 cells.

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Monocyte and macrophage heterogeneity and Toll-like receptors in the lung.

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