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Innate immunity in the human endometrium and ovary.

Author information

Affiliations

  • 1. Centre for Reproductive Immunobiology, Institute of Life Science, College of Medicine, Swansea University, Swansea, UK.
      Authors
    • Sheldon IM 1
    (1 author)

ORCIDs linked to this article

American Journal of Reproductive Immunology (New York, N.Y. : 1989), 01 Jul 2011, 66 Suppl 1:63-71
https://doi.org/10.1111/j.1600-0897.2011.01034.x PMID: 21726339 

Review

Abstract 

Problem

Microbial infections of the upper female genital tract perturb the function of the endometrium and ovary. Defense of these tissues is predominantly dependent on innate immunity. This review gives a perspective on innate immunity in the non-pregnant upper female genital tract of women.

Method of study

Literature review of innate immunity in the human endometrium and ovary.

Results

The endometrium is defended against microbes by physical barriers, antimicrobial peptides, complement, Toll-like receptors (TLRs), and other pattern recognition receptors. Endometrial epithelial and stromal cells express TLRs, which sense pathogen-associated molecular patterns (PAMPs), leading to an inflammatory response with the influx of neutrophils and macrophages. Innate immunity in the endometrium is regulated by steroids, eicosanoids, and cytokines. Granulosa cells also express TLRs and respond to PAMPs.

Conclusion

Pattern recognition receptors have roles in endometrial and ovarian inflammation, and innate immunity is central to the defense of the endometrium against pathogens.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/j.1600-0897.2011.01034.x

Read article for free, from open access legal sources, via Unpaywall: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0897.2011.01034.xUnpaywall

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Funding 

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Biotechnology and Biological Sciences Research Council (2)